Aliases

• APC
• BTPS2
• DP2
• DP2.5
• DP3
• Deleted in polyposis 2.5
• FPC
• GS
• Protein APC
• adenomatosis polyposis coli
• adenomatosis polyposis coli tumor suppressor
• adenomatous polyposis coli

Description

The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. Promoter hypermethylation is an alternative pathway for gene silencing in neoplastic cells and a promising cancer detection marker. Methylation levels of GSTP1, APC, and RASSF1A are associated with advanced grade and stage in prostate tumors. Quantitative methylation-specific PCR (QMSP) might augment the pathologic indicators currently used to predict prostate tumor aggressiveness.

Attributes

QA State

Under Review

Type

Genomic

HGNC Name

APC