AMACR
- Aliases
-
- 2-methylacyl-CoA racemase
- AMACR
- AMACRD
- CBAS4
- RACE
- RM
- alpha-methylacyl-CoA racemase
- Description
- AMACR, a racemase, is an enzyme that interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from the gene locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Frequent overexpression of AMACR has been detected in prostate cancer tumors.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- AMACR
- Certifications
-
- None
- QA State for Prostate
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.
- A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray.
- alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.