ALDH1A2
- Aliases
-
- ALDH1A2
- Aldehyde dehydrogenase family 1 member A2
- EC 1.2.1.36
- RALDH 2
- RALDH(II)
- RALDH2
- RALDH2-T
- RalDH2
- Retinaldehyde-specific dehydrogenase type 2
- aldehyde dehydrogenase 1 family, member A2
- retinal dehydrogenase 2
- retinaldehyde-specific dehydrogenase type 2
- Description
- From NCBI Gene: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
Attributes
- QA State
- Curated
- Type
- Gene
- HGNC Name
- ALDH1A2
- Certifications
-
- None
- QA State for Prostate
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account.
- Diagnosis of prostate cancer using differentially expressed genes in stroma.
- Expression changes in the stroma of prostate cancer predict subsequent relapse.
- The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.