AFP

Description…

From NCBI Gene: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]

The following organs have data associated with this biomarker…

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

• Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.
• Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.
• Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
• Mining gene expression databases for association rules.
• Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.

• Protein RefSeq sequence for human AFP, of which AFP-L3 is an isoform
• HGNC entry 317 for AFP, human alpha-fetoprotein.
• FDA web page describing approval of AFP-L3
• KEGG entry 174 human alpha-fetoprotein
• UniProtKB/Swiss-Prot entry P02771 human alpha-fetoprotein, of which AFP-L3 is an isoform