ADH5
- Aliases
-
- ADH-3
- ADH5
- ADHX
- Alcohol dehydrogenase 5
- Alcohol dehydrogenase class chi chain
- Alcohol dehydrogenase class-III
- EC 1.1.1.1,EC 1.1.1.-,EC 1.1.1.284
- FALDH
- FDH
- GSH-FDH
- GSNOR
- Glutathione-dependent formaldehyde dehydrogenase
- S-(hydroxymethyl)glutathione dehydrogenase
- alcohol dehydrogenase (class III), chi polypeptide
- alcohol dehydrogenase 5 (class III), chi polypeptide
- alcohol dehydrogenase class chi chain
- alcohol dehydrogenase class-3
- alcohol dehydrogenase class-III
- formaldehyde dehydrogenase
- glutathione-dependent formaldehyde dehydrogenase
- Description
- From NCBI Gene: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- ADH5
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.