Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)	Coordinating	0	0
Non-Invasive Testing for Advanced Adenomas	Coordinating	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)	Involved	1	0

Publications

Publication Name	PubMed ID	Journal
Assessing aneuploidy with repetitive element sequencing.	32075918	Proc Natl Acad Sci U S A
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.	21041628	Proc Natl Acad Sci U S A
Colorectal cancer prevention: Immune modulation taking the stage.	29391185	Biochim Biophys Acta Rev Cancer
Detection and localization of surgically resectable cancers with a multi-analyte blood test.	29348365	Science
Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs).	29432176	Proc Natl Acad Sci U S A
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.	32345712	Science
One year recurrence of aberrant crypt foci.	20570885	Cancer Prev Res (Phila)
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.	21490394	J Clin Invest
Tumor DNA as a Cancer Biomarker through the Lens of Colorectal Neoplasia.	33033144	Cancer Epidemiol Biomarkers Prev

Interests

Colorectal Cancer Screening, Colon Cancer Biomarkers

Robert E. Schoen, M.D., M.P.H. is a Professor of Medicine and Epidemiology at the University of Pittsburgh and serves as Director of Colorectal and GI Cancer Prevention and Control Research for the University of Pittsburgh Cancer Institute. His research interests are in evaluating screening for colorectal cancer, encouraging use of screening tests, and in developing new biomarkers for early detection of cancer. He is the chair of the colorectal subcommittee for the NCI Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer screening trial, a randomized study of flexible sigmoidoscopy with over 154,000 participants. Dr. Schoen is evaluating intermediate biomarkers of colorectal cancer including endoscopic markers such as aberrant crypt foci, and serum markers based on nuclear matrix proteins.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

University of Pittsburgh Cancer Institute

Degree(s)

M.D., M.P.H

Email

rschoen@pitt.edu

Fax

412-648-9378

Person ID

1050

EDRN Title

EDRN Principal Investigator

Note

To update contact information, please visit the Data Management and Coordinating Center .