2:00-2:05pm

Welcome

Chair: Marc Lenburg, PhD, Boston University

Co-Chair: Eric Grogan, MD, Vanderbilt University Medical Center

NCI Program Directors:

• Guillermo Marquez, PhD, National Cancer Institute
• Wendy Wang, PhD, National Cancer Institute
• Zhong Chen, MD, PhD, National Institute of Dental and Craniofacial Research

2:05-2:50pm

Technology Presentations (10 min, 5 Q&A)

Moderator: TBD

• 01: Tom Morrison, PhD, Accugenomics
• 02: David Wong, DMD, DMSc, University of California Los Angeles "EFIRM Liquid Biopsy "
• 03: Mathias Ehrich, MD, Nucleix

2:50-3:00pm

Open discussion about potential trans BRL projects

Moderators:

• Marc Lenburg, PhD, Boston University
• Eric Grogan, MD, Vanderbilt University Medical Center

3:00-3:05pm

Break

Part 1: Lung and H&N groups (8 min, 2 Q&A)

Moderator: Eric Grogan MD

3:05-3:15pm

04: Karen Anderson, PhD, Arizona State University

Erich Sturgis, MD, MPH, Brown Foundation

H&N: High-Throughput Immunoproteomics for Cancer Biomarker Discovery

3:15-3:25pm

05: William Hsu, PhD, David Geffen School of Medicine at UCLA

Imaging Biomarker Development for Risk-Stratifying Indeterminate Pulmonary Nodules

3:25-3:35pm

06: Silvio Gutkind, PhD (presenting virtually), Ludmil Alexandrov, PhD (not attending) and Scott Lippman, MD, University of California, San Diego

Mapping Immuno-Genomic Drivers of the Head and Neck Precancer Invasive-Disease Transition

3:35-3:45pm

07: Matthew Schabath, PhD, H. Lee Moffitt Cancer Center & Research Institute, Inc.

Quantitative Pan-Cancer Imaging CVC at Moffitt Cancer Center

3:45-3:55pm

08: Joshua LaBaer, MD, PhD, Arizona State University

Lung: High-Throughput Immunoproteomics for Cancer Biomarker Discovery

3:55-4:05pm

09: Leopoldo Nicolas Segal, MD, New York University School of Medicine

Microbial And Host Biomarker Development for Detection and Prognosis Of Early Stage Non-Small Cell Lung Cancer

4:05-4:15pm

10: Yu Leo Lei, DDS, PhD, The University of Texas MD Anderson Cancer Center

Steven Chinn, MD, MPH and Thomas Wang, MD, PhD, University of Michigan at Ann Arbor

Advancing On-Slide and Optical Biopsy Tools To Detect High-Risk Oral Premalignancy

4:15-4:25pm

11: Eric L Grogan, MD, Vanderbilt University Medical Center

Clinical Utility of a Combined Biomarker Approach to Diagnose Lung Cancer

4:25-4:35pm

12: Fatemeh Momen Heravi, DDS, PhD, MPH, Columbia University Health Sciences

Immune And Transcriptomic Biomarkers of Progressive Oral Premalignant Lesions

4:35–4:40pm

Break

Part 2: Lung and H&N groups (8 min, 2 Q&A)

Moderator: Eric Grogan MD

4:40-4:50pm

13: Laura Rozek, PhD, MS, Georgetown University

Oral Dysplasias to Carcinomas: Multi-Omics Study of Progression

4:50-5:00pm

14: Victor Velculescu, MD, PhD, Johns Hopkins University

DNA Evaluation of Fragments for Early Interception (DELFI) Of Lung Cancer

5:00-5:10pm

15: Sara Pai, MD, PhD, Yale University

Ralph Weissleder, MD, PhD, Massachusetts General Hospital

Early Detection and Risk of Head and Neck Cancer Through Immune Based Spatial Omics

5:10-5:20pm

16: James G. Herman, MD, University Of Pittsburgh

Optimizing Ultrasensitive DNA Methylation Detection for Lung Cancer and Other Malignancies

5:20-5:30pm

17: Anna Giuliano, PhD, MS and Antonio Amelio, PhD, MS, H. Lee Moffitt Cancer Center & Research Institute

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

5:30-5:40pm

18: Samir M. Hanash, MD, PhD, University of Texas MD Anderson Cancer Center

Clinical Validation Center for Lung Cancer Early Detection

5:40-5:50pm

19: Hua Li, PhD and Xiaowei Wang, PhD, Washington University

Combined Imaging and RNA Analyses to Predict Head and Neck Cancer Recurrence

5:50 – 6:00pm

Open discussion: 10-minute:

Focused on identifying areas of intergroup synergy and preparing for presentation at SC session the following day.