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Benoit, Nicole

Staff, Johns Hopkins University School of Medicine, 410-502-5133

Contact Information

Email: mailto:nbenoit@jhmi.edu
Fax:

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
GSTP1 Methylation 0 1
Integrated Development of Novel Molecular Markers 0 0
Molecular Progression of Methylation in Bladder Cancer 0 0
A Methylation Panel for Bladder Cancer 0 0
Identification of biomarkers for lung cancer in never smokers 0 29
Protocol for Comparing Promoter Hypermethylation Methods in NSCLC 0 0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer 8 0
Methylation & Proteomics-Based Detection of Bladder Cancer 0 0
Proteomic Approach for Diagnostic Applications in Head and Neck Cancer 0 0

Publications

Publication Name PubMed ID Journal
The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. 16862168 Oncogene
RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma. 16619251 Int. J. Cancer
Assessment of gene promoter hypermethylation for detection of cervical neoplasia. 16736496 Int. J. Cancer
Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. 16908936 J. Clin. Oncol.
Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. 16849682 J. Natl. Cancer Inst.
PGP9.5 methylation in diffuse-type gastric cancer. 16585221 Cancer Res.
Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. 14633692 Cancer Res.
Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. 16565507 Am. J. Pathol.
LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. 16912160 Cancer Res.
Mitochondrial DNA mutations in human cancer. 16892080 Oncogene
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. 11745231 Cancer
Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. 11448914 Clin. Cancer Res.
Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer. 11550279 Genes Chromosomes Cancer
Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. 11221887 Cancer Res.
Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues. 11448537 Cancer Lett.
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. 11555585 Clin. Cancer Res.
Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. 11429699 Oncogene
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer. 11410508 Clin. Cancer Res.
Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. 11280771 Cancer Res.
Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer. 17016690 J. Mol. Med.
Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. 11585726 Cancer Res.
Quantitative detection of promoter hypermethylation as a biomarker of acute kidney injury during transplantation. 17175292 Transplant. Proc.
Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. 17118488 Lung Cancer
Mitochondrial mutations in early stage prostate cancer and bodily fluids. 11526508 Oncogene
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer. 11719438 Cancer Res.
Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. 11809682 Cancer Res.
Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. 15814621 Clin. Cancer Res.
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. 17020408 PLoS Med.
Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. 17018594 Cancer Res.
Molecular characteristics of non-small cell lung cancer. 11752463 Proc. Natl. Acad. Sci. U.S.A.
Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. 15753360 Cancer Res.
Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer. 17166268 Mol. Cancer
Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma. 11717336 J. Natl. Cancer Inst.
I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. 12010858 Cancer Epidemiol. Biomarkers Prev.
Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. 17018150 BMC Cancer
Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. 11606403 Cancer Res.
Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. 15812243 DNA Cell Biol.
Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer. 18094415 Clin. Cancer Res.
An oligonucleotide microarray for high-throughput sequencing of the mitochondrial genome. 16931588 J Mol Diagn
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. 18234960 Mol. Cancer Res.
Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. 18245469 Cancer Res.
DCC promoter hypermethylation in esophageal squamous cell carcinoma. 18302152 Int. J. Cancer
Genome-wide promoter analysis uncovers portions of the cancer methylome. 18413733 Cancer Res.
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. 17456585 Cancer Res.
Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. 17534889 Int. J. Cancer
Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. 17592394 Laryngoscope
Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. 17980147 Biochem. Biophys. Res. Commun.
Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma. 11839667 Clin. Cancer Res.
A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma. 18006766 Clin. Cancer Res.
Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. 18082200 J. Urol.
Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. 18172258 Clin. Cancer Res.
Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. 17405999 J. Natl. Cancer Inst.
Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. 17549626 Breast Cancer Res. Treat.
Quantitation of serum prostate-specific membrane antigen by a novel protein biochip immunoassay discriminates benign from malignant prostate disease. 11507047 Cancer Res.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. 15930319 Cancer Res.
Quantitative assessment of promoter methylation profiles in thyroid neoplasms. 15840741 J. Clin. Endocrinol. Metab.
Oxidized guanine lesions and hOgg1 activity in lung cancer. 15856018 Oncogene
MT1G hypermethylation is associated with higher tumor stage in prostate cancer. 15894685 Cancer Epidemiol. Biomarkers Prev.
Increased mitochondrial DNA content in saliva associated with head and neck cancer. 15814624 Clin. Cancer Res.
Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. 16170165 J. Clin. Oncol.
Mitochondrial DNA as a cancer biomarker. 15858150 J Mol Diagn
Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. 16322291 Clin. Cancer Res.
Quantitative GSTP1 hypermethylation in bodily fluids of patients with prostate cancer. 12475696 Urology
Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma. 12576869 J. Urol.
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study. 11882817 J. Thorac. Cardiovasc. Surg.
Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation. 12114429 Clin. Cancer Res.
Endothelin B receptor gene hypermethylation in prostate adenocarcinoma. 12499435 J. Clin. Pathol.
Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis. 12727855 Cancer Res.
Proteomic analysis of cancer-cell mitochondria. 14570046 Nat. Rev. Cancer
Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies. 14600096 J. Natl. Cancer Inst.
Optimal use of a panel of methylation markers with GSTP1 hypermethylation in the diagnosis of prostate adenocarcinoma. 15328191 Clin. Cancer Res.
Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. 15289362 Cancer Res.
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. 15342377 Cancer Res.
Quantitative RARbeta2 hypermethylation: a promising prostate cancer marker. 15217932 Clin. Cancer Res.
Quantitative GSTP1 methylation levels correlate with Gleason grade and tumor volume in prostate needle biopsies. 15126784 J. Urol.
The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. 15123581 Genome Res.
Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. 15073103 Clin. Cancer Res.
Detecting cervical cancer by quantitative promoter hypermethylation assay on cervical scrapings: a feasibility study. 15192122 Mol. Cancer Res.
Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. 18246124 Oncogene
Detection of LOH and mitochondrial DNA alterations in ductal lavage and nipple aspirate fluids from hngh-risk patients. 14999140 Breast Cancer Res. Treat.
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. 17456604 Proc. Natl. Acad. Sci. U.S.A.
Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer. 15515012 Int. J. Cancer
Mitochondrial DNA content increase in response to cigarette smoking. 16434581 Cancer Epidemiol. Biomarkers Prev.
Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. 16533782 Clin. Cancer Res.
p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study. 12837832 J. Natl. Cancer Inst.
Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations. 12917199 Cancer Epidemiol. Biomarkers Prev.
Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma. 17360030 Gynecol. Oncol.
Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer. 16263813 J. Clin. Endocrinol. Metab.
Mitochondrial DNA alterations in thyroid cancer. 12619060 J Surg Oncol
Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients. 12684406 Clin. Cancer Res.
Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. 12578990 Proc. Natl. Acad. Sci. U.S.A.
Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. 12727856 Cancer Res.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

6607 Copper Ridge Dr. Apt. #101
Johns Hopkins School of Medicine; Dept Otolaryngology

To update addresses, please visit the Data Management and Coordinating Center.

Announcement 06/30/2017

The next EDRN Steering Committee Meeting is from September 12-14, 2017, in Seattle WA. Please click here to register and find out more information about the meeting.

Announcement



EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.