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Meltzer, Stephen (M.D.)

PI, Johns Hopkins University, 410-502-6071

Contact Information

Fax: 410-502-3109
EDRN Associate Member

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Polyp Prediction Study 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
Barrett's Esophagus Methylation Profiles 11 1


Publication Name PubMed ID Journal
Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. 11861396 Cancer Res.
Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. 17912343 PLoS ONE
Sparse logistic regression with Lp penalty for biomarker identification. 17402921 Stat Appl Genet Mol Biol
Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing. 18389087 Bioinform Biol Insights
Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. 17408633 Gastroenterology
Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability. 16012936 Gastroenterology
Prediction of survival in patients with esophageal carcinoma using artificial neural networks. 15751017 Cancer
Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. 15574757 Cancer Res.
Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability. 11507051 Cancer Res.
HNPCC-associated small bowel cancer: clinical and molecular characteristics. 15765394 Gastroenterology
Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors. 14691305 Lab. Invest.
Genome-wide methylation analysis shows similar patterns in Barrett's esophagus and esophageal adenocarcinoma. 23996928 Carcinogenesis
Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes. 15520171 Cancer Res.
Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression. 15221970 Int. J. Cancer
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. 15107828 Oncogene
Transcriptional responses of intestinal epithelial cells to infection with Vibrio cholerae. 15213169 Infect. Immun.
Prediction of lymph node metastasis with use of artificial neural networks based on gene expression profiles in esophageal squamous cell carcinoma. 15545505 Ann. Surg. Oncol.
Promoter methylation regulates cyclooxygenase expression in breast cancer. 15217498 Breast Cancer Res.
Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis. 16449976 Oncogene
A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray. 16446548 Oncology
RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas. 16557577 Int. J. Cancer
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. 16172218 Cancer Epidemiol. Biomarkers Prev.
Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma. 18425214 Bioinform Biol Insights
An ultrasensitive new DNA microarray chip provides gene expression profiles for preoperative esophageal cancer biopsies without RNA amplification. 18511875 Oncology
Promoter methylation and response to chemotherapy and radiation in esophageal cancer. 16678495 Clin. Gastroenterol. Hepatol.
Thapsigargin resistance in human prostate cancer cells. 16770788 Cancer
Polo-like kinase and survivin are esophageal tumor-specific promoters. 16487489 Biochem. Biophys. Res. Commun.
Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma. 16837775 Oncology
Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression. 17121882 Clin. Cancer Res.
Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer. 11964046 Virchows Arch.
Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. 12101425 Oncogene
Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. 12097267 Cancer Res.
Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays. 11821959 Oncogene
Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions. 11874992 Gastroenterology
Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer. 12067993 Cancer Res.
Activation of the esophagin promoter during esophageal epithelial cell differentiation. 12036303 Genomics
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. 11313962 Oncogene
Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning. 15059896 Cancer Res.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.


1503 E. Jefferson St., Room 112
Johns Hopkins University

To update addresses, please visit the Data Management and Coordinating Center.

Announcement 6/2/2018
Thank you to everyone to made the 10th EDRN Scientific Workshop a success. The next event is the 33rd EDRN Steering Committee Meeting from September 5-6, 2018 in Boston, MA. Details will be available soon.

Announcement 6/1/2018

Dr. Sudhir Srivastava was honored with the 2017 Human Proteome Organization (HUPO) Award for a Distinguished Scientist in Clinical and Translational Proteomics. Please join us in congratulating him on his accomplishments and contributions. The awards were presented at HUPO 2017 in Dublin, Ireland and the winners were present to provide a small talk during the Awards Ceremony and HUPO Lectures.