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Block, Timothy (Ph.D.)

PI, Drexel University College of Medicine, (215) 489-4948

Contact Information

Email: mailto:timothy.block@drexelmed.edu
Fax: (215) 489-4920
EDRN Associate Member
Hepatitis, Herpes, Glycovirol

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Detection of cancer DNA markers in urine 0 0
Early detection of liver cancer and hepatitis 0 0
Liver Full Reference Set Application :Timothy Block - Drexel Univ (2010) 4 0
SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
Liver Rapid Reference Set Application: Timothy Block - Drexel Univ (2008) 4 0

Publications

Publication Name PubMed ID Journal
Hepatitis B and hepatitis C virus replication upregulates serine protease inhibitor Kazal, resulting in cellular resistance to serine protease-dependent apoptosis. 19864383 J. Virol.
A proteomic approach for the discovery of early detection markers of hepatocellular carcinoma. 11790885 Dis. Markers
A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma. 12748940 Proteomics
Molecular viral oncology of hepatocellular carcinoma. 12910247 Oncogene
Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. 14997503 Proteomics
Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. 15642945 Proc. Natl. Acad. Sci. U.S.A.
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. 19091367 Virology
Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes. 19187787 J. Virol. Methods
Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma. 19099421 J. Proteome Res.
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer. 15096565 J Mol Diagn
A phage with high affinity for hepatitis B surface antigen for the detection of HBsAg. 15109821 J. Virol. Methods
Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA. 14709652 Clin. Chem.
Detection of a K-ras mutation in urine of patients with colorectal cancer. 17192038 Cancer Biomark
Efficient and specific removal of albumin from human serum samples. 12754305 Mol. Cell Proteomics
Transrenal DNA as a diagnostic tool: important technical notes. 15251944 Ann. N. Y. Acad. Sci.
Symptomatology and health attitudes of chronic hepatitis B patients in the USA. 18088244 J. Viral Hepat.
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. 18837947 Ann. N. Y. Acad. Sci.
Underestimation of chronic hepatitis B virus infection in the United States of America. 18088239 J. Viral Hepat.
Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity? 16569195 DNA Cell Biol.
Molecular virology of hepatitis B virus for clinicians. 17981225 Clin Liver Dis
Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells. 12692252 J. Virol.
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. 17237271 Mol. Cancer Ther.
Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma. 16457596 J. Proteome Res.
Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays. 16780964 Antiviral Res.
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine. 18837929 Ann. N. Y. Acad. Sci.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

3805 Old Easton Road
Drexel University College of Medicine

To update addresses, please visit the Data Management and Coordinating Center.

Announcement



EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.