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Bigbee, William L. (Ph.D.)

PI, University of Pittsburgh Cancer Institute, 412-641-7555

Contact Information

Email: mailto:bigbeewl@upmc.edu
Fax: 412-641-2458
EDRN Associate Member
Clinical Proteomics

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
EDRN Informatics Pilot Project 0 0
Collaborative study on SELDI biomarker discovery and serum protein profiling of lung cancers 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
Standard Specimen Reference Set: Lung 0 0
Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer 8 0
EDRN Resource Network Exchange 0 0
EDRN-WHI Pre-Clinical Colon Ca Specimens 0 9
Proteomic Approach for Diagnostic Applications in Head and Neck Cancer 0 0
Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers 0 0
SELDI Phase I: Assay Validation-Prostate 0 1
SELDI Validation Study Phase II 0 3

Publications

Publication Name PubMed ID Journal
Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients. 15744170 Laryngoscope
Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. 11880476 J. Natl. Cancer Inst.
[Rabies vaccination with regards to its epidemiology (author's transl)]. 1237467 Immun. Infekt.
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 Cancer Res.
Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer. 15258333 Dis. Markers
Feature Selection for Classification of SELDI-TOF-MS Proteomic Profiles. 16309341 Appl. Bioinformatics
[Analysis of proteomic spectra in serum from patients with laryngeal carcinoma by SELDI-TOF-MS technology]. 20359086 Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Identification of nuclear matrix protein alterations associated with human colon cancer. 11956108 Cancer Res.
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. 15613711 Clin. Chem.
Assessing the statistical significance of the achieved classification error of classifiers constructed using serum peptide profiles, and a prescription for random sampling repeated studies for massive high-throughput genomic and proteomic studies. 19305632 Cancer Inform
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer. 12844488 Carcinogenesis
Identification of calreticulin as a nuclear matrix protein associated with human colon cancer. 12704787 J. Cell. Biochem.
Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. 17909350 J Thorac Oncol
Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract. 15754315 Mol. Carcinog.
No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer. 15066937 Cancer Epidemiol. Biomarkers Prev.
Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. 14718398 Clin. Chem.
Early identification of individuals with prostate cancer in negative biopsies. 15017188 J. Urol.
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. 13679857 Oncogene
Colon cancer specific nuclear matrix protein alterations in human colonic adenomatous polyps. 14743395 J. Cell. Biochem.
Intersession reproducibility of mass spectrometry profiles and its effect on accuracy of multivariate classification models. 17766268 Bioinformatics
Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia. 19536772 Head Neck
Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients. 17545511 Clin. Cancer Res.
Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling. 17220337 Cancer Epidemiol. Biomarkers Prev.
SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer. 18024530 Clin. Chem.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

Magee Women's Research Institute, Suite B411, 204 Craft Avenue
University of Pittsburgh Cancer Institute

To update addresses, please visit the Data Management and Coordinating Center.

Announcement



EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.