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Palko, Sharon R

Staff, The Ohio State University Medical Center, 6142923063

Contact Information


To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) 0 0

Closed Protocols

No closed protocols.


Publication Name PubMed ID Journal
miRNA profiling of cancer. 23465882 Curr. Opin. Genet. Dev.
A new role for microRNAs, as ligands of Toll-like receptors. 23296026 RNA Biol
Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. 23405235 PLoS ONE
Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. 23409773 Mol. Cancer
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer. 23589849 Proc. Natl. Acad. Sci. U.S.A.
MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. 23550646 Immunol. Rev.
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. 19498445 Cell Death Differ.
Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer. 19926640 Carcinogenesis
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. 21518799 J. Exp. Med.
Codeine-induced pulmonary oedema (an unusual cause of dyspnoea). 22315434 QJM
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. 22753494 Proc. Natl. Acad. Sci. U.S.A.
Identification of microRNA activity by Targets' Reverse EXpression. 19897564 Bioinformatics
Interplay between microRNAs and the epigenetic machinery: an intricate network. 20493980 Biochim. Biophys. Acta
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. 20332227 Cancer Res.
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. 20388878 J. Natl. Cancer Inst.
Modulation of mismatch repair and genomic stability by miR-155. 20351277 Proc. Natl. Acad. Sci. U.S.A.
LINCing chromatin remodeling to metastasis. 20829831 Nat. Biotechnol.
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. 21057537 Oncogene
Oncogenic role of miR-483-3p at the IGF2/483 locus. 20388800 Cancer Res.
Reprogramming of miRNA networks in cancer and leukemia. 20439436 Genome Res.
Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. 20051373 Cancer Prev Res (Phila)
MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. 21300873 Proc. Natl. Acad. Sci. U.S.A.
MicroRNAs as regulators of death receptors signaling. 19644509 Cell Death Differ.
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. 19730444 Cell Death Differ.
miR-EdiTar: a database of predicted A-to-I edited miRNA target sites. 23044546 Bioinformatics
MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. 22210864 Nucleic Acids Res.
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. 22351564 EMBO Mol Med
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. 20802525 Oncogene
microRNAs: Master regulators as potential therapeutics in cancer. 20809797 Annu. Rev. Pharmacol. Toxicol.
miRNAs in precancerous lesions of the gastrointestinal tract. 22219591 World J. Gastroenterol.
microRNA involvement in human cancer. 22491715 Carcinogenesis
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer. 22986525 Oncogene
MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation. 23012423 Proc. Natl. Acad. Sci. U.S.A.
Causes and consequences of microRNA dysregulation. 22647357 Cancer J
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. 22157681 Nat. Med.
MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). 21078976 Proc. Natl. Acad. Sci. U.S.A.
Mutated beta-catenin evades a microRNA-dependent regulatory loop. 21383185 Proc. Natl. Acad. Sci. U.S.A.
Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. 21383199 Proc. Natl. Acad. Sci. U.S.A.
miRNAs in the spotlight: Understanding cancer gene dependency. 21818092 Nat. Med.
Role of microRNAs in lymphoid biology and disease. 21519241 Curr. Opin. Hematol.
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. 23505378 PLoS Genet.
Clinical applications for microRNAs in cancer. 23212103 Clin. Pharmacol. Ther.
In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation. 23610125 J. Exp. Med.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.


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Announcement 11/09/2018

The 34th EDRN Steering Committee Meeting is from March 18-20, 2019 in Nashville, TN. Details available in January, 2019.

The subsequent meeting will be an EDRN Scientific Workshop, on September 10-12, 2019, in the Washington D.C. area.