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Ouellette, Michel (Ph.D.)

Staff, University of Nebraska Medical Center, 402-559-5556

Contact Information

Email: mailto:mouellet@unmc.edu
Fax:

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Hollingsworth - Aggressive vs Indolent 2012 0 0
Pancreatic Reference Set Application: Michael Hollingsworth-University of Nebraska (2014) 0 0
Biomarkers for the Early Detection of Pancreatic Cancer 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies 0 0
Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer 0 0

Publications

Publication Name PubMed ID Journal
Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis. 24371222 Cancer Res.
Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells. 17595659 Br. J. Cancer
MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer. 24240113 Clin. Cancer Res.
MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer. 24204560 PLoS ONE
MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster. 24143167 PLoS ONE
Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. 16258363 Pancreas
Complete suppression of tumor formation by high levels of basement membrane collagen. 18171981 Mol. Cancer Res.
Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies. 16794264 Stem Cells
Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. 18781152 Br. J. Cancer
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. 22869720 Proc. Natl. Acad. Sci. U.S.A.
Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies. 17671448 Clin. Pharmacol. Ther.
Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications. 17273942 Cancer Metastasis Rev.
Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer. 18791122 Gut
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. 17979879 J. Cell. Mol. Med.
Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers. 18427384 Panminerva Med
Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. 18288619 Stem Cell Rev
Dynamics of the immune reaction to pancreatic cancer from inception to invasion. 17909062 Cancer Res.
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies. 17355951 Ann. Oncol.
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. 18515410 Gut
Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia. 18392050 Br. J. Cancer
Ras-driven transformation of human nestin-positive pancreatic epithelial cells. 18374182 Meth. Enzymol.
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. 19633682 Oncogene
Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. 17786164 Clin. Pharmacol. Ther.
Pathobiological implications of MUC16 expression in pancreatic cancer. 22066010 PLoS ONE
Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia. 17714470 Histopathology
Sonic hedgehog promotes desmoplasia in pancreatic cancer. 18829478 Clin. Cancer Res.
Modelling oncogenic Ras/Raf signalling in the mouse. 19201597 Curr. Opin. Genet. Dev.
The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. 20697347 Oncogene
Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. 23446997 Clin. Cancer Res.
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway. 14583090 Biochem. J.
Pancreatic enzyme extract improves survival in murine pancreatic cancer. 15097858 Pancreas
Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. 14729877 J. Histochem. Cytochem.
Mucins in cancer: protection and control of the cell surface. 14681689 Nat. Rev. Cancer
Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. 14744777 Cancer Res.
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. 21734707 Nature
Tumor suppression by collagen XV is independent of the restin domain. 22531369 Matrix Biol.
Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis. 23754791 Int. J. Cancer
Culture and immortalization of pancreatic ductal epithelial cells. 15542901 Methods Mol. Med.
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. 16397221 Cancer Res.
Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases. 16487661 Biochim. Biophys. Acta
MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implications. 17032197 Am. J. Gastroenterol.
Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats. 16405548 Am. J. Gastroenterol.
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. 15894267 Cancer Cell
ErbB2 growth factor receptor, a marker for neuroendocrine cells? 15775699 Pancreatology
Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. 15280401 J. Clin. Pathol.
Loss of fibulin-2 expression is associated with breast cancer progression. 17456760 Am. J. Pathol.
Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. 17234748 Cancer Res.
Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. 17404500 Cancer Biol. Ther.
The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. 17215257 Glycobiology
MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms. 16799633 Oncogene
Human RNA polymerase II-associated factor complex: dysregulation in cancer. 17599057 Oncogene
Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. 17914743 J. Cell. Biochem.
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. 18381409 Cancer Res.
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. 17545600 Cancer Res.
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. 17332339 Cancer Res.
MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. 17974963 Cancer Res.
A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosis. 17431413 Mod. Pathol.
CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity. 17273764 Int. J. Oncol.
Structure, evolution, and biology of the MUC4 mucin. 18024835 FASEB J.
Characterization of human mucin MUC17. Complete coding sequence and organization. 16737958 J. Biol. Chem.
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies. 16195239 Carcinogenesis
MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. 16857800 Clin. Cancer Res.
Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125). 16880776 Mod. Pathol.
Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates. 17019794 Am. J. Clin. Pathol.
MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. 16049287 J. Clin. Pathol.
Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. 22412968 PLoS ONE
Notch 2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells. 15924149 Lab. Invest.
Cell surface-associated mucins in signal transduction. 16904320 Trends Cell Biol.
Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance. 16207894 Glycobiology
Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. 16302265 Prostate
MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. 18475301 Br. J. Cancer
Engineering antibodies for clinical applications. 17512622 Trends Biotechnol.
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. 16491129 Oncogene
Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells. 18322957 World J. Gastroenterol.
Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer. 19012856 Lancet Oncol.
Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. 21825040 Clin. Cancer Res.
MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. 17126950 Lung Cancer
Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth. 21625220 Oncogene
MUC4, a multifunctional transmembrane glycoprotein, induces oncogenic transformation of NIH3T3 mouse fibroblast cells. 19010895 Cancer Res.
Evaluation of MUC6 mucin tandem repeats. 15716126 Biochim. Biophys. Acta
MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. 17406026 Mol. Cancer Res.
The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. 18830939 Histol. Histopathol.
ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. 17721921 Int. J. Cancer
Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. 18625714 J. Biol. Chem.
Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. 22864396 Cancer Immunol. Immunother.
Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation. 17309914 Clin. Cancer Res.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

986805 Nebraska Medical Center
UNMC

To update addresses, please visit the Data Management and Coordinating Center.

Announcement



EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.