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Markowitz, Sanford (M.D., Ph.D.)

PI, Case Western Reserve University, 213-844-8237

Contact Information

Email: mailto:sxm10@po.cwru.edu
Fax: 213-844-8230
EDRN Principal Investigator

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis 0 0
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2) 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1) 1 0

Publications

Publication Name PubMed ID Journal
The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis. 22302717 Genes Chromosomes Cancer
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. 21045206 Sci Signal
Allele-specific expression of TGFBR1 in colon cancer patients. 20705955 Carcinogenesis
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. 21349845 J. Biol. Chem.
Epigenomic enhancer profiling defines a signature of colon cancer. 22499810 Science
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). 24760190 Sci Transl Med
Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. 24793120 Gastroenterology
Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies. 22315367 Cancer Epidemiol. Biomarkers Prev.
NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. 23874207 PLoS Genet.
Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms. 27790711 Int. J. Cancer
The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. 25492499 Dig. Dis. Sci.
Inhibition of 15-hydroxyprostaglandin dehydrogenase by Helicobacter pylori in human gastric carcinogenesis. 23430757 Cancer Prev Res (Phila)
Cancer bypasses the lymph nodes. 28684492 Science
Global mutational profiling of formalin-fixed human colon cancers from a pathology archive. 22878650 Mod. Pathol.
Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus. 26545406 Cancer Epidemiol. Biomarkers Prev.
RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. 27503924 Cancer Res.
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. 23717544 PLoS ONE
Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention. 23625286 Dig. Dis. Sci.
Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus. 29343623 Sci Transl Med
Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2). 28886423 Neoplasia

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

11001 Euclid Avenue, Suite 200
Case Western Reserve University

To update addresses, please visit the Data Management and Coordinating Center.

Announcement 03/14/2018
Thank you to everyone to made the 10th EDRN Scientific Workshop a success. The next event is the 33rd EDRN Steering Committee Meeting from September 5-6, 2018 in Boston, MA. Details will be available soon.


Three new FOAs on the Human Tumor Atlas and associated with the Cancer Moonshot Initiative have been released. Please click here for more information.

Announcement 10/23/2017

Three new FOAs on the Human Tumor Atlas and associated with the Cancer Moonshot Initiative have been released. Please click here for more information.

EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.