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Lokshin, Anna (Ph.D.)

PI, University of Pittsburgh Cancer Instititute, 412-623-7706

Contact Information

Email: mailto:lokshina@pitt.edu
Fax: 412-623-3355
EDRN Associate Member

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Biomarkers for early detection of pancreatic cancer 0 1
Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside) 0 1
A Biomarker Bakeoff in Early Stage Pancreatic Cancer 0 0

Closed Protocols

Protocol Name Biomarkers Datasets
BRSCW Reference Set Application: Anna Lokshin - Univ of Pitts (2008) 0 0
Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer 4 0
PLCO Ovarian Phase III Validation Study 50 1
Prostate Rapid Pre-Validation Set 6 0
SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study 55 2

Publications

Publication Name PubMed ID Journal
Obesity, adipokines, and prostate cancer in a prospective population-based study. 16835332 Cancer Epidemiol. Biomarkers Prev.
Multiplexed immunobead-based cytokine profiling for early detection of ovarian cancer. 15824174 Cancer Epidemiol. Biomarkers Prev.
Combined antiangiogenic and immune therapy of prostate cancer. 16132614 Angiogenesis
High-sensitivity blood-based detection of breast cancer by multi photon detection diagnostic proteomics. 16889412 J. Proteome Res.
Multianalyte profiling of serum cytokines for detection of pancreatic cancer. 17192050 Cancer Biomark
Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies? 17029028 Cancer Metastasis Rev.
Adenosine-mediated inhibition of the cytotoxic activity and cytokine production by activated natural killer cells. 16885379 Cancer Res.
Multiple biomarker panels for early detection of ovarian cancer. 17155900 Future Oncol
Multiple effects of TRAIL in human carcinoma cells: induction of apoptosis, senescence, proliferation, and cytokine production. 18313665 Exp. Cell Res.
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1. 16728283 Exp. Hematol.
Multiplex analysis of serum cytokines in melanoma patients treated with interferon-alpha2b. 17438101 Clin. Cancer Res.
Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). 17337770 Immunol. Res.
Assessment of 54 biomarkers for biopsy-detectable prostate cancer. 17932343 Cancer Epidemiol. Biomarkers Prev.
Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. 18327580 Cancer Immunol. Immunother.
Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis? 15880317 Clin. Gastroenterol. Hepatol.
Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin. 17659325 Gynecol. Oncol.
Early detection and staging of adenocarcinoma of the pancreas. 17533087 Gastroenterol. Clin. North Am.
Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo. 15843547 J. Immunol.
Dynamic alteration of soluble serum biomarkers in healthy aging. 17689975 Cytokine
Low-dose paclitaxel prior to intratumoral dendritic cell vaccine modulates intratumoral cytokine network and lung cancer growth. 17875775 Clin. Cancer Res.
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling. 17575165 Cancer Res.
IL-12 receptor-mediated upregulation of FasL in human ovarian carcinoma cells. 15382042 Int. J. Cancer
Biomarker approaches to the development of cancer screening tests: can cancer blood tests become a routine health check-up? 17547524 Future Oncol
New tumor markers: CA125 and beyond. 16343244 Int. J. Gynecol. Cancer
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. 16737935 Biol. Blood Marrow Transplant.
Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt. 12878156 Exp. Cell Res.
Physiological and molecular effects of Apo2L/TRAIL and cisplatin in ovarian carcinoma cell lines. 12536078 Cancer Lett.
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth. 14695193 Cancer Res.
Role of antiapoptotic proteins in tumor necrosis factor-related apoptosis-inducing ligand and cisplatin-augmented apoptosis. 12912965 Clin. Cancer Res.
Effect of suramin on squamous differentiation and apoptosis in three human non-small-cell lung cancer cell lines. 8806101 J. Cell. Biochem. Suppl.
Interleukin-2-induces development of denditric cells from cord blood CD34+ cells. 9581807 J. Leukoc. Biol.
Induction of squamous differentiation by interferon beta in a human non-small-cell lung cancer cell line. 7905929 J. Natl. Cancer Inst.
Prevention and early detection of ovarian cancer: mission impossible? 17302189 Recent Results Cancer Res.
Tumor's other immune targets: dendritic cells. 10449178 J. Leukoc. Biol.
Mechanism of interferon beta-induced squamous differentiation and programmed cell death in human non-small-cell lung cancer cell lines. 7707408 J. Natl. Cancer Inst.
Mechanisms of growth stimulation by suramin in non-small-cell lung cancer cell lines. 10071987 Cancer Chemother. Pharmacol.
Intravenous and isolated limb perfusion delivery of wild type and a tumor-selective replicating mutant vaccinia virus in nonhuman primates. 16409123 Hum. Gene Ther.
Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer. 16434085 Gynecol. Oncol.
Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. 12202400 Int. Immunol.
Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3. 10100610 FEBS Lett.
Early effects of retinoic acid on proliferation, differentiation and apoptosis in non-small cell lung cancer cell lines. 10697544 Anticancer Res.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

5117 Centre Avenue, Suite 1.19d
University of Pittsburgh Cancer Instititute

To update addresses, please visit the Data Management and Coordinating Center.

Announcement



EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.