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Grady, William (M.D.)

PI, Fred Hutchinson Cancer Research Center, 206-667-1107

Contact Information

Email: mailto:wgrady@fredhutch.org
Fax: 206-667-2917
EDRN Principal Investigator

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name Biomarkers Datasets
Using the methylome to identify aggressive Barrett’s esophagus 0 0
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2) 0 0

Closed Protocols

No closed protocols.

Publications

Publication Name PubMed ID Journal
Making the case for DCC and UNC5C as tumor-suppressor genes in the colon. 18054576 Gastroenterology
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. 16708352 Genes Chromosomes Cancer
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. 17349581 Cancer Cell
Genomic instability and colorectal cancer. 17024019 Curr. Opin. Gastroenterol.
CIMP and colon cancer gets more complicated. 17938428 Gut
Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. 17278092 Int. J. Cancer
DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas? 17339242 Gut
The next thing in prognostic molecular markers: microRNA signatures of cancer. 20551450 Gut
Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations. 21298349 Ann. Surg. Oncol.
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. 15709190 Clin. Cancer Res.
Colorectal cancer molecular biology moves into clinical practice. 20921207 Gut
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. 16820927 Oncol. Rep.
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. 17047044 Cancer Res.
Linking epidemiology to epigenomics--where are we today? 21149325 Cancer Prev Res (Phila)
RET is a potential tumor suppressor gene in colorectal cancer. 22751117 Oncogene
DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation. 23024594 Sarcoma
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. 17985359 Genes Chromosomes Cancer
Epigenetic biomarkers in esophageal cancer. 22406828 Cancer Lett.
Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo. 23604118 Oncogene
DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia. 23226306 PLoS ONE
TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines. 18651288 Growth Factors
Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer. 22688851 Am. J. Gastroenterol.
Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. 23539450 Cancer Res.
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. 18264139 Oncogene
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. 19208363 Gastroenterology
TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta. 19339207 Biochim. Biophys. Acta
DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. 22139570 Epigenetics
Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. 16108056 Int. J. Cancer
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. 18425817 Int. J. Cancer
Genomic and epigenetic instability in colorectal cancer pathogenesis. 18773902 Gastroenterology
Insights into the role of DNA methylation in disease through the use of mouse models. 20427558 Dis Model Mech
Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry. 21497289 J Mol Diagn
Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. 22170739 Genes Chromosomes Cancer
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. 19777566 Mol. Carcinog.
Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction. 19491834 Am. J. Gastroenterol.
Epigenetics and colorectal cancer. 22009203 Nat Rev Gastroenterol Hepatol

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.

Addresses

1100 Fairview Avenue N., D4-100
Fred Hutchinson Cancer Research Center

To update addresses, please visit the Data Management and Coordinating Center.

Announcement



EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.