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Specimen Reference Sets

Documentation, EDRN guidelines, and application forms for specimen reference sets

General Documents for Reference Sets

EDRN Guidelines

Application Form for EDRN Reference Sets

Ovarian & Breast Cancer Reference Sets

Biomarker Reference Sets for Cancers in Women (BRSCW) (PDF)
Description of pooled reference sets for ovarian and breast cancer serum specimens
BRSCW Application Form

Breast Cancer Reference Set

Breast Reference Set Summary (PDF)

Breast Reference Set Protocol (PDF)

Breast Reference Set Participant and Clinical Forms (PDF)

Application Form for EDRN Reference Sets

Lung Cancer Reference Sets

Lung Cancer Reference Set Documentation (PDF)
The goal of the NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) is to develop the requisite sample resources to pre-validate serum/plasma biomarkers for the early diagnosis of lung cancer.
Lung Cancer Reference Set Application Form (Online Form)

Colon Cancer Reference Set

Colon Cancer Reference Set Description (PDF)
Application Form for EDRN Reference Sets

 

Prostate Cancer Reference Set

Prostate Cancer Reference Set Description (PDF)
One of the goals of the EDRN Genitourinary (GU) Collaborative Group is the establishment of a biologic sample set on men prior to prostate biopsy, in association with clinical information and common data elements appropriate for evaluation of risk and prognosis of prostate cancer.
Application Form for EDRN Reference Sets

Liver (Hepatocellular Carcinoma) Reference Set

Hepatocellular Carcinoma Reference Set Description (PDF)
Application Form for EDRN Reference Sets

EDRN Benign Breast Disease Tissue Resource(BBD)

BBD Reference Set Application (PDF)

BBD Reference Set Summary Document (PDF)

SOP For Selection of Benign Breast Disease Project

Pancreatic Standard Specimen Reference Set

Pancreatic Cancer Reference Set Access Information (PDF)
Application Form for EDRN Reference Sets

PCA3 Validation Study and Urinary Reference Set

Application Form for EDRN Reference Sets

Bladder Cancer (MSA)Reference Set

Application Form for EDRN Reference Sets
New Funding Opportunity: Biomarker Development Laboratories for the Early Detection Network: Applications Due May 23

Update: Pre-application webinar information now available.

The National Cancer Institute's Division of Cancer Prevention has released a new funding opportunity to solicit organ-specific applications for Biomarker Developmental Laboratories (BDLs), one of the four scientific units of the recently funded Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. BDLs are responsible for the discovery, development, characterization, and testing of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of cancers.

The existing BDLs are primarily focused on ovary and gastrointestinal cancers. The proposed BDLs (to be supported under this funding opportunity) should be focused on one or more of the following cancers: breast, prostate and other genitourinary organs, or lung. In addition, cancers with rapidly rising incidence rates, e.g., endometrial, hepatocellular, kidney, thyroid, oropharyngeal cancers, and/or cancers with unique etiology, e.g., mesothelioma, will be considered.

The newly funded units of the Early Detection Research Network will be announced later in April. Successful applicants have already been notified. Those researchers who were not successful during the last round of applications are encouraged to apply to this opportunity.