Early Detection Research Network

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.

Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.

Adonizio CS, Bettegowda C, Bhattacharya P, Buchanan AH, Cohain AT, Cohen JD, Diehl DL, Douville C, Fishman EK, Hagmann LN, Honushefsky A, Hruban RH, Hwang HJ, Kann L, Kinde I, Kinzler KW, Klein A, Lahouel K, Ledbetter DH, Leeming R, Lengauer C, Lennon AM, Malani N, Papadopoulos N, Parker A, Patel AA, Rolston DD, Rosica D, Salvati ZM, Sanfilippo F, Sheridan K, Still CD, Tomasetti C, Urban B, Vadakara J, Vogelstein B, Walter C, Warren A, Woods JI, Zhou S


Science, 2020, 369 (6499)

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