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Consensus guidelines for the detection of immunogenic cell death.

  • Kepp O
  • Senovilla L
  • Vitale I
  • Vacchelli E
  • Adjemian S
  • Agostinis P
  • Apetoh L
  • Aranda F
  • Barnaba V
  • Bloy N
  • Bracci L
  • Breckpot K
  • Brough D
  • Buqué A
  • Castro MG
  • Cirone M
  • Colombo MI
  • Cremer I
  • Demaria S
  • Dini L
  • Eliopoulos AG
  • Faggioni A
  • Formenti SC
  • Fučíková J
  • Gabriele L
  • Gaipl US
  • Galon J
  • Garg A
  • Ghiringhelli F
  • Giese NA
  • Guo ZS
  • Hemminki A
  • Herrmann M
  • Hodge JW
  • Holdenrieder S
  • Honeychurch J
  • Hu HM
  • Huang X
  • Illidge TM
  • Kono K
  • Korbelik M
  • Krysko DV
  • Loi S
  • Lowenstein PR
  • Lugli E
  • Ma Y
  • Madeo F
  • Manfredi AA
  • Martins I
  • Mavilio D
  • Menger L
  • Merendino N
  • Michaud M
  • Mignot G
  • Mossman KL
  • Multhoff G
  • Oehler R
  • Palombo F
  • Panaretakis T
  • Pol J
  • Proietti E
  • Ricci JE
  • Riganti C
  • Rovere-Querini P
  • Rubartelli A
  • Sistigu A
  • Smyth MJ
  • Sonnemann J
  • Spisek R
  • Stagg J
  • Sukkurwala AQ
  • Tartour E
  • Thorburn A
  • Thorne SH
  • Vandenabeele P
  • Velotti F
  • Workenhe ST
  • Yang H
  • Zong WX
  • Zitvogel L
  • Kroemer G
  • Galluzzi L

25941621

Oncoimmunology. 2014 Oct 3 (9).

in vitro and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine.

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