You are here: Home / Publications / New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization.

New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization.

24124229

Cancer Discov. 2013 Oct 3 (10).

Limited understanding of the functional link between multiple oncogenic pathways is a major barrier in the ongoing effort of cancer biologists to design an effective therapeutic approach to treat malignancies characterized by driver oncogenic network signals. In this issue of Cancer Discovery, Tan and colleagues elucidate a novel PDK1-PLK1-MYC signaling pathway connecting two fundamental oncogenic programs, phosphoinositide 3-kinase and MYC. They define the functional role for PDK1-PLK1-MYC signaling in cancer cell survival and tumor formation and show the therapeutic benefit of inhibiting PDK1 and PLK1 pharmacologically in cancer, tackling the most undruggable tumors defined by elevated levels of the MYC oncoprotein.

This icon signifies that something is happening and we kindly ask you to please wait