Early Detection Research Network

SLC45A3-ELK4 chimera in prostate cancer: spotlight on cis-splicing.

Using a series of detailed experiments, Zhang and colleagues establish that the prostate cancer RNA chimera SLC45A3-ELK4 is generated by cis-splicing between the 2 adjacent genes and does not involve DNA rearrangements or trans-splicing. The chimera expression is induced by androgen treatment likely by overcoming the read-through block imposed by the intergenic CCCTC insulators bound by CCCTC-binding factor repressor protein. The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation.

Chinnaiyan AM, Kalyana-Sundaram S, Kumar-Sinha C


Cancer Discov, 2012, 2 (7)

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