You are here: Home / Publications / Dynamic alteration of soluble serum biomarkers in healthy aging.

Dynamic alteration of soluble serum biomarkers in healthy aging.

  • Shurin GV
  • Yurkovetsky ZR
  • Chatta GS
  • Tourkova IL
  • Shurin MR
  • Lokshin AE

17689975

Cytokine. 2007 Aug 39 (2).

Dysbalanced production of inflammatory cytokines is involved in immunosenescence in aging. The age-related changes of the levels of circulating inflammatory mediators and their clinical importance have not been investigated until recently. Still, little is known about the influence of aging on circulating levels of many cytokines, chemokines, growth factors, and angiogenic factors. In the present study, we evaluated the effect of aging on 30 different serum biomarkers involved in pro- and anti-inflammatory responses using multianalyte LabMAP Luminex technology. The simultaneous measurement of serological markers has been done in 397 healthy subjects between 40 and 80 years old. We demonstrated an increase in serum interferon-gamma-inducible chemokines (MIG and IP-10), eotaxin, chemoattractant for eosinophils, and soluble TNFR-II with advancing age. Serum levels of EGFR and EGF, important regulators of cell growth and differentiation, were decreased with age in healthy donors. These data suggest novel pathways, which may be involved in age-associated immunosenescence.

This icon signifies that something is happening and we kindly ask you to please wait