Early Detection Research Network

Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.

An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.

12692252

J. Virol., 2003, 77 (9)

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