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Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.

12692252

J. Virol.. 2003 May 77 (9).

An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.

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