You are here: Home / Protocols


EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.


Title Abstract Investigator
Colon Reference Set Application: Robert Getzenberg - Johns Hopkins (2008) The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and ... Not listed
Colon Reference Set Application: Mary Disis - University of Washington (2008) The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a ... Disis, Mary L
Colon Reference Set Application: Moncef Jendoubi - Milagen (2006) Confidential Jendoubi, Moncef
Colon Reference Set Application: Nam Kim - DiaDexus (2008) The EDRN Colorectal reference samples will be useful in confirming the potential application of novel serum markers for colorectal cancer that can detect ... Kim, Nam
DCIS Team Project Both overtreatment and undertreatment of DCIS are pervasive problems given that no useful approaches for identifying which DCIS patients are likely or highly ... Li, Christopher
Detecting Breast Cancer Signatures in Body Fluids Trock, Bruce
Detecting breast cancer protein signatures in body fluid Semmes, John
Detection of Bladder CA by Microsatellite Analysis (MSA) Goal 1: To determine sensitivity and specificity of microsatellite analysis (MSA) of urine sediment, using a panel of 15 microsatellite markers, in detecting ... Schoenberg, Mark P.
Detection of Serum Markers of Breast Cancer by SELDI Marks, Jeffrey
Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study Esserman, Laura J.
Detection of cancer DNA markers in urine Block, Timothy
Development and Clinical Validation of Biomarkers for Prostate Cancer Partin, Alan W
Development and Evaluation of a Tumor Marker for Prostate Cancer Major strides in the early detection, staging, monitoring, and risk stratification of men with prostate cancer have been realized over the last few decades. ... Partin, Alan W
Development and Validation of Tissue Microarray Technology to Evaluate Molecular Alterations in Cancer. IRBMED# 2000-0108 Chinnaiyan, Arul M.
Development of Breast Cancer Biomarkers Using DNA and Protein Microarray Technologies Chinnaiyan, Arul M.
Development of FISH-based assay for early detection of high grade cervical dysplasia Unger, Elizabeth R.
Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer Gambhir, Sanjiv
Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets Esserman, Laura J.
Development of reference samples and interlaboratory testing to improve the confidence in the measurement of microRNAs Provide measurement assurance for miRNA profiling studies Plant, Anne
Discovery of Novel Gene Elements Associated with Prostate Cancer Progression Chinnaiyan, Arul M.
Dubinett - Targeted Sequencing 2012 we propose to use targeted massively parallel DNA sequencing to identify somatic alterations within mutational hotspots in matched sets of primary lung tumors, ... Dubinett, Steve
EDRN Biomarker Reference Lab: Pacific Northwest National Laboratory The purpose of this project is to develop antibody microarrays incorporating three major improvements compared to previous antibody microarray platforms, and ... Liu, Tao
EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project To identify promising candidate plasma early detection biomarkers specific to different molecular subtypes of breast cancer using preclinical specimens from ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ... Li, Christopher
EDRN Informatics Pilot Project Bigbee, William L.
EDRN Longitudinal Serum Biorepository Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ... Lynch, Henry
EDRN Pre-Validation of Metabolic Biomarkers of Prostate Cancer: Follow up EDRN Challenge The goal of this EDRN set-asides proposal is to carry out pre-validation studies on sarcosine as a metabolomic biomarker of prostate cancer in urine. Not only ... Chinnaiyan, Arul M.
EDRN Pre-Validation of Multiplex Biomarker in Urine The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in ... Chinnaiyan, Arul M.
Announcement 09/27/2019
Thank you to everyone who made the 11th EDRN Scientific Workshop a success. The next EDRN Steering Committee Meeting is from Tuesday-Thursday, March 31-April 2, 2020 in Tempe, AZ.

This icon signifies that something is happening and we kindly ask you to please wait