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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
Colon Cancer Specimen Reference Set Application: Disis - University of Washington (2008) The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a ... Disis, Mary L
Colon Cancer Specimen Reference Set Application: Getzenberg - Johns Hopkins (2008) The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and ... Getzenberg, Robert H.
Colon Cancer Specimen Reference Set Application: Jendoubi - Milagen (2006) No Data Received at DMCC Jendoubi, Moncef
Colon Cancer Specimen Reference Set Application: Kim - DiaDexus (2008) Kim, Nam
DCIS Team Project This procedure applies to identification of the cohort and of cases and controls from the cohort of women with the diagnosis of DCIS at the Seattle CVC (PI= ... Li, Christopher
DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. We used MethyLight assays to analyze DNA methylation status of 27 genes on 49 paired cancerous and noncancerous tissue samples from non-small cell lung cancer ... Feng, Qinghua
Depo-Provera and Breast Cancer: Epidemiology/Pathology The injectable contraceptive depot medroxy-progesterone acetate (DMPA) (Depo-Provera) is commonly used by women worldwide, and it contains the same progestin ... Li, Christopher
Detecting Breast Cancer Signatures in Body Fluids Trock, Bruce
Detecting breast cancer protein signatures in body fluid Semmes, John
Detection of Bladder CA by Microsatellite Analysis (MSA) Goal 1: To determine sensitivity and specificity of microsatellite analysis (MSA) of urine sediment, using a panel of 15 microsatellite markers, in detecting ... Schoenberg, Mark P.
Detection of Serum Markers of Breast Cancer by SELDI Marks, Jeffrey
Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study Esserman, Laura J.
Detection of cancer DNA markers in urine Block, Timothy
Development and Clinical Validation of Biomarkers for Prostate Cancer Partin, Alan W
Development and Evaluation of a Tumor Marker for Prostate Cancer Major strides in the early detection, staging, monitoring, and risk stratification of men with prostate cancer have been realized over the last few decades. ... Partin, Alan W
Development of FISH-based assay for early detection of high grade cervical dysplasia Unger, Elizabeth R.
Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer Gambhir, Sanjiv
Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer. PURPOSE: Non-small cell lung cancer (NSCLC) has an overall 5-year survival of <15%; however, the 5-year survival for stage I disease is over 50%. ... Farlow, Erin C.
Development of autoantibody signatures as novel diagnostic biomarkers of non-small cell lung cancer PURPOSE: To select autoantibody signatures as noninvasive biomarkers of non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: A phage cDNA expression ... Wu, Lingling
Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets Esserman, Laura J.
Dubinett - Targeted Sequencing 2012 we propose to use targeted massively parallel DNA sequencing to identify somatic alterations within mutational hotspots in matched sets of primary lung tumors, ... Dubinett, Steve
EDRN Biomarker Reference Lab: Pacific Northwest National Laboratory The purpose of this project is to develop antibody microarrays incorporating three major improvements compared to previous antibody microarray platforms, and ... Rodland, Karin
EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project There is an urgent need for breast cancer early detection biomarkers given that none are currently available and given the considerable public health ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ... Li, Christopher
EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ... Li, Christopher
EDRN Informatics Pilot Project Bigbee, William L.
EDRN Longitudinal Serum Biorepository Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ... Lynch, Henry
EDRN Pre-Validation of Metabolic Biomarkers of Prostate Cancer: Follow up EDRN Challenge The goal of this EDRN set-asides proposal is to carry out pre-validation studies on sarcosine as a metabolomic biomarker of prostate cancer in urine. Not only ... Chinnaiyan, Arul M.
EDRN Pre-Validation of Multiplex Biomarker in Urine The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in ... Chinnaiyan, Arul M.
News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement