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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
The Early Detection Research Network: Biomarker Reference Laboratories Chia, David
The Prostate Tumor Microenvironment Exhibits differentially expressed Genes Useful for Diagnosis To develop a multi-site prospective clinical validation trial of the multigene diagnostic signature for the diagnosis of prostate cancer from non tumor ... Mercola, Dan
Triple Negative Breast Cancer Team Project Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ... Anderson, Karen
US-Turkey Cappadocia Mesothelioma Project Study never launched. Pass, Harvey Ira
Upgrading Reference Set We are proposing a multi-institutional study to identify molecular biomarkers and clinical measures that will predict presence of Gleason 7 or higher cancer ... Thompson, Ian M.
Using MALDI-IMS and MRM to stablish a pipeline for discovery and validation of tumor neovasculature biomarker candidates. In an effort to circumvent the limitations associated with biomarker discovery workflows involving cell lines and cell cultures, histology-directed MALDI ... Gambhir, Sanjiv
Using the methylome to identify aggressive Barrett’s esophagus OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ... Grady, William
Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population A prospective study to evaluate the utility of various biomarkers in the context of an MM Early Detection Program. The study cohort will be composed of workers ... Pass, Harvey Ira
Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010) We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ... Brenner, Dean
Validation of Early Detection Ovarian Cancer Biomarkers (Team Project) Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ... Skates, Steven
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) To characterize intra or within subject reproducibility and variability To characterize inter or across subject variability by adenoma phenotype (normal vs. ... Spira, Avrum
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques 1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ... Hanash, Samir
Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early ... Parikh, Neehar
Validation of the Mutagen Sensitivity and Chromosomal Hotspot Assays Spitz, Margaret R.
Year 2 Collaborative Project - UCSF and Battelle PNWD To evaluate the effects of receptor status on circulating biomarker levels. Zangar, Richard (Rick) C.
Announcement 04/26/2017

A new funding opportunity associated with the Beau Biden Cancer Moonshot Initiative, Integration and Validation of Emerging Technologies to Accelerate Cancer Research, has been released and is due May 10, 2017. Click here for more information.

Announcement 03/14/2017

Thank you to everyone who made the March 2017 EDRN Steering Committee Meeting a success. The next EDRN Steering Committee Meeting will be on September 12-14, 2017, in Seattle, WA.

EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.