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Protocols

EDRN investigators protocols. The following is a list of the EDRN protocols that have been captured and curated. Additional information will be added as it is available. Contact information is provided as part of the detail for each protocol.

Contents

Title Abstract Investigator
Standard Specimen Reference Set: Lung The NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) began its activities back in November 2004 and developed clear objectives and strategies on how to begin ... Bigbee, William L.
Standard Specimen Reference Set: Pancreatic The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens ... Brand, Randall E.
Standard Specimen Reference Set: Prostate To collect biologic samples on men prior to prostate biopsy, in association with clinical information and common data elements appropriate for evaluation of ... Sanda, Martin
Standard Specimen Reference Set: Colon The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, ... Brenner, Dean
Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates Li, Christopher
Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict ... Markowitz, Sanford
The Biomarker Knowledge System Informatics Pilot Project Supplement To The Biomarker Development Laboratory at Moffitt (Bedlam) The Biomarker Knowledge System Informatics Pilot Project goal will develop network interfaces among databases that contain information about existing clinical ... Tockman, Melvyn S.
The Early Detection Research Network: Biomarker Reference Laboratories Chia, David
The Prostate Tumor Microenvironment Exhibits differentially expressed Genes Useful for Diagnosis To develop a multi-site prospective clinical validation trial of the multigene diagnostic signature for the diagnosis of prostate cancer from non tumor ... Mercola, Dan
Triple Negative Breast Cancer Team Project Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ... Anderson, Karen
US-Turkey Cappadocia Mesothelioma Project Study never launched. Pass, Harvey Ira
Upgrading Reference Set We are proposing a multi-institutional study to identify molecular biomarkers and clinical measures that will predict presence of Gleason 7 or higher cancer ... Leach, Robin J
Using MALDI-IMS and MRM to stablish a pipeline for discovery and validation of tumor neovasculature biomarker candidates. In an effort to circumvent the limitations associated with biomarker discovery workflows involving cell lines and cell cultures, histology-directed MALDI ... Gambhir, Sanjiv
Using the methylome to identify aggressive Barrett’s esophagus OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ... Grady, William
Uterine Lavage This project investigates the complementarity of tumor DNA (tDNA) in uterine lavage to serum proteins for detection of ovarian cancer and builds on the results ... Skates, Steven
Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population A prospective study to evaluate the utility of various biomarkers in the context of an MM Early Detection Program. The study cohort will be composed of workers ... Pass, Harvey Ira
Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010) We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ... Brenner, Dean
Validation of Early Detection Ovarian Cancer Biomarkers (Team Project) Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ... Skates, Steven
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) To characterize intra or within subject reproducibility and variability To characterize inter or across subject variability by adenoma phenotype (normal vs. ... Spira, Avrum
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques 1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ... Hanash, Samir
Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early ... Parikh, Neehar
Validation of the Mutagen Sensitivity and Chromosomal Hotspot Assays Spitz, Margaret R.
Year 2 Collaborative Project - UCSF and Battelle PNWD To evaluate the effects of receptor status on circulating biomarker levels. Zangar, Richard (Rick) C.
Announcement 10/23/2017

Three new FOAs on the Human Tumor Atlas and associated with the Cancer Moonshot Initiative have been released. Please click here for more information.

32nd SC Meeting
Thank you to everyone who made the 32nd EDRN Steering Committee meeting a success. The next event is the 10th EDRN Scientific Workshop from March 6-8, 2018 in Bethesda, MD. More information about this Workshop will be sent soon. Click here to view the flyer.
EDRN Founder Honored

Dr. Sudhir Srivastava was honored with the Distinguished Service Award from the American Pancreatic Association at the group's annual meeting this year, for his outstanding commitment to pancreatology.