Early Detection Research Network

PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS

PASS Ref Set App: Lin (2010) TMPRSS2-ERG
368

No coordinating investigator defined.

Urinary PCA3 and TMPRSS2:ERG
No design specified.
Proteomics
Prostate and Urologic Cancers Research Group
2

Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.

1.   Assess the frequency of TMPRSS2:ERG gene-fusion in whole urines of an active surveillance population. 2.   Evaluate urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression. 3.   Evaluate longitudinal changes in urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression.
Gen-Probes TMA assay

No datasets are currently associated with this protocol.


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