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Breast Reference Set Application: GeorgeTuszynski-Temple (2012)

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Tuszynski, GeorgeTemple University
Feng, ZidingFred Hutchinson Cancer Research Center
CA125, CA19.9, CA15.3, CEA, GASP-1
Proteomics
Breast and Gynecologic Cancers Research

As recommended by the review committee, we will analyze 30 invasive cancer cases and 30 benign controls from the EDRN breast reference set. Cases and controls should be selected that are Caucasian and post-menopausal. It is suggested that the Caucasian cases and controls match as closely as possible in regards to age and body mass index.

We are addressing the question of whether G-protein coupled receptor-associated sorting protein 1 (GASP-1) initially discovered in the serum of breast cancer patients can be used as a serum biomarker for the early detection, diagnosis or prognosis of breast cancer.
We will use logistic regression to test if GASP-1 is associated with case-control status after adjustment for age and body mass index. As described in the breast cancer reference set description document, with sample size of 30 cases and 30 controls the study has excellent power for a positive result if the marker is associated with breast cancer (OR=5 for a dichotomized version of the marker). An age-adjusted ROC curve and AUC for the GASP-1 marker will be calculated along with bootstrap confidence limits

No datasets are currently associated with this protocol.


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