Early Detection Research Network

Final Agenda

Gastrointestinal and Associated Cancers Collaborative Group Virtual Meeting

Tuesday, June 30, 2020

11:00 a.m. – 5:30 p.m. EDT

Chair:

Robert Schoen, M.D., M.P.H., University of Pittsburgh

Co-Chair:

Brian Haab, Ph.D., Van Andel Institute

NCI Program Directors:

Jo Ann Rinaudo, Ph.D., and Matthew Young Ph.D., National Cancer Institute

11:00 a.m. – 2:00 p.m. EDT

Colon and Esophageal:

11:00 a.m. – 11:15 a.m. EDT Welcome and Introduction
GI01: Robert Schoen, M.D., M.P.H., University of Pittsburgh,
ctDNA for monitoring of CRC

11:15 a.m. – 11:20 a.m. EDT

Q&A

11:20 a.m. – 11:35 a.m. EDT GI02: Kamel Lahouel, Johns Hopkins University,
A statistical method for analyzing circulating tumor DNA

11:35 a.m. – 11:40 a.m. EDT

Q&A

11:40 a.m. – 11:55 a.m. EDT GI03: Jason Liggett, Ph.D., EDP Biotech,
Serum based multiplex protein assay for early detection of colorectal cancer and precancerous lesions in a FIT positive population

11:55 a.m. – 12:00 p.m. EDT

Q&A

12:00 p.m. - 12:15 p.m. EDT GI04: Paul Lampe, Ph.D., Fred Hutchinson Cancer Research Center,
Update on phase 3 validation of colon cancer markers and the collaborative group project

12:15 p.m. - 12:20 p.m. EDT

Q&A

12:20 p.m. – 12:40 p.m. EDT

Lunch Break

12:40 p.m. – 12:55 p.m. EDT
GI05: Larry LaPointe, Ph.D., Clinical Genomics,
Update on TRIDENT, a three-gene biomarker assay for colorectal neoplasia

12:55 p.m. – 1:00 p.m. EDT

Q&A

1:00 p.m. - 1:15 p.m. EDT
GI06: Ming Yu, Ph.D., Fred Hutchinson Cancer Research Center,
Methylated EVL is a potential risk biomarker for colorectal cancer

1:15 p.m. - 1:20 p.m. EDT

Q&A

1:20 p.m. - 1:35 p.m. EDT
GI07: William Grady, M.D., Fred Hutchinson Cancer Research Center,
Biomarkers of Barrett’s Esophagus and esophageal adenocarcinoma

1:35 p.m. - 1:40 p.m. EDT

Q&A

1:40 p.m. – 2:00 p.m. EDT

SWOT (Strengths, Weaknesses, Opportunities, and Threats) Analysis

  • Discuss the strengths of EDRN and suggestions to further strengthen the Network
  • Identify weaknesses and discuss the solutions (Mitigation)
  • Discuss opportunities and highlight prioritized opportunities
  • Discuss threats (competing interests/research) and mitigations

2:00 p.m. - 2:15 p.m. EDT

Break

2:15 p.m. – 5:30 p.m. EDT
PDAC
2:15 p.m. – 2:30 p.m. EDT GI08: Progress in the Development of PDAC Biomarkers: Haab-Brand-Allen BDL
Brian Haab, Ph.D., Van Andel Institute

2:30 p.m. – 2:35 p.m. EDT

Q&A

2:35 p.m. – 2:50 p.m. EDT GI09: Validation of Mucin Based Biomarkers for Early Diagnosis of Pancreatic Neoplasms
Surinder Batra, Ph.D., University of Nebraska Medical Center

2:50 p.m. – 2:55 p.m. EDT

Q&A

2:55 p.m. – 3:10 p.m. EDT GI10:  Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection
Johannes Fahrmann, Ph.D., The University of Texas MD Anderson Cancer Center

3:10 p.m. – 3:15 p.m. EDT

Q&A

3:15 p.m. – 3:25 p.m. EDT

Break

3:25 p.m. - 3:40 p.m. EDT GI11: Update on CVC Collaborations, Supplemental Projects and Team Project 3
Randall Brand, M.D., University of Pittsburgh Medical Center

3:40 p.m. - 3:45 p.m. EDT

Q&A

3:45 p.m. - 4:00 p.m. EDT GI12: An Update to the Pancreatic Cyst Biomarker Alliance (PCBA): Is the (cyst) juice worth the squeeze?
Aatur Singhi, M.D., University of Pittsburgh Medical Center

4:00 p.m. - 4:05 p.m. EDT

Q&A

4:05 p.m. - 4:20 p.m. EDT GI13: Alliance of Pancreatic Consortia (APaCC): Pre-diagnostic and early stage PDAC imaging repository project
Eugene Koay, M.D., The University of Texas MD Anderson Cancer Center

4:20 p.m. - 4:25 p.m. EDT

Q&A

4:25 p.m. - 4:40 p.m. EDT GI14: Pancreatic Cancer Bake-Off Projects Updates
Ying Huang, Ph.D., Fred Hutchinson Cancer Research Center

4:40 p.m. - 4:45 p.m. EDT

Q&A

4:45 p.m. - 5:00 p.m. EDT Team Project Group Discussion
5:00 p.m. - 5:30 p.m. EDT
SWOT (Strengths, Weaknesses, Opportunities, and Threats) Analysis
  • Discuss the strengths of EDRN and suggestions to further strengthen the Network
  • Identify weaknesses and discuss the solutions (Mitigation)
  • Discuss opportunities and highlight prioritized opportunities
  • Discuss threats (competing interests/research) and mitigations

5:30 p.m. EDT

Adjourn

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