Early Detection Research Network

G.I. and Other Associated Cancers Research Group

Haab, Brian
Schoen, Robert E.
4DELF
Identification of preneoplastic changes in histologically normal epithelium (the "field effect") could provide a powerful screening tool for colorectal cancer. …
8 Gene Panel for Barretts Esophagus
Eight methylation biomarkers - p16, RUNX3, HPP1 (HGNC name TMEFF2), NELL1, TAC1, SST, AKAP12 and CDH13 - were tested in a restrospective multicenter …
Aberrant Vimentin DNA Methylation in Stool
The VIM gene encodes a member of the intermediate filament family. VIM proteins are class-III intermediate filaments found in various non-epithelial cells, …
AFP
From NCBI Gene: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein …
AFP-L3
AFP-L3, also known as lectin-bound AFP, is an isoform of AFP, a major plasma protein produced by the yolk sac and the liver during fetal life. …
AFPIC
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with …
AKAP12
AKAP12 is a member of the A-kinase anchor protein (AKAP) family, a group of structurally diverse proteins which have the common function of binding to the …
ALCAM
CD166 is a sticky cell adhesion molecule that binds to CD6. It is involved in neurite extension by neurons via heterophilic and homophilic interactions and may …
APOA1
APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for …
AREG
From NCBI Gene: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for …
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker …
CancerSEEK
Detection of genetic mutations associated with pancreatic and ovarian cancer. FDA approved in 2019. Commercial partner is Thrive Earlier Detection Corp.
CCSA-2
CCSA-2 is a potential serum-based marker for colon cancer detection with high sensitivity and specificity. Receiver operating characteristic analyses were used …
CCSA-3
Colon cancer-specific antigen CCSA-3 is a novel colon cancer marker of colorectal cancer and advanced adenomas identified by focused proteomic analysis of …
CCSA-4
Colon cancer-specific antigen CCSA-4 is a novel colon cancer marker of colorectal cancer and advanced adenomas identified by focused proteomic analysis of …
CCSP-1
Expression microarrays have identified colon cancer secreted protein-1 (CCSP-1) as a novel transcript whose expression is generally absent in normal colon and …
CCSP-2
Expression microarrays have identified colon cancer secreted protein-2 (CCSP-2) as a novel transcript whose expression is generally absent in normal colon and …
CD14
From NCBI Gene: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other …
CDH13
CDH13 is a member of the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular …
CTNNB1
From NCBI Gene: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation …
CTSE
From NCBI Gene: This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least …
DCP
Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal …
DCP and AFP-L3 risk biomarkers for HCC
DCP and AFP-L3 panel for the detection of hepatocellular carcinoma (HCC). DCP (des-gamma carboxy-prothrombin) and AFP-L3 (lectin-bound alpha-fetoprotein) as a …
DISP3
From UniprotKB: Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By …
EsoGuard
EsoGuard is to detect, diagnose, and manage patients with Barrett's esophagus. Currently pending FDA approval.
EYA4
From NCBI Gene: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its …
FOXE1
From NCBI Gene: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved …
galectin-3 ligand
Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin. Galectin-3 …
GNAS
From NCBI Gene: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts …
GP73
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi transmembrane …
Haptoglobin-related glycoprotein
A major circulating ligand for galectin-3, which is elevated in the sera of patients with colon cancer, is a cancer-associated glycoform of haptoglobin. In …
HGF
From NCBI Gene: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after …
HSPG2
HSPG2, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached, is a large …
ICAM1
From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to …
IGFBP4
The IGFBP4 gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin …
KNG1
Kininogens are inhibitors of thiol proteases. The KNG1 gene uses alternative splicing to generate two different proteins- high molecular weight kininogen …
KRAS
The KRAS gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single …
LEBS
Low-coherence enhanced backscattering (LEBS) is a technique that has recently shown promise for tissue characterization and the detection of early pre-cancer. …
MCAM
From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its …
Meltzer 3 marker panel for Esophageal Adenocarcinoma
Using real-time quantitative methylation-specific PCR, ten genes (HPP1, RUNX3, RIZ1, CRBP1, 3-OST-2, APC, TIMP3, p16, MGMT and p14) were screened for promoter …
Meltzer 3 marker panel with clinical features for Esophageal Adenocarcinoma
Barrett's esophagus predisposes to esophageal adenocarcinoma. This biomarker is part of a three-tiered risk stratification strategy, based on systematically …
MUC4
From NCBI Gene: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are …
MUC5AC
From UniProtKB/Swiss-Prot: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by …
MUC5AC:BGH
A glycoform of MUC5AC bound to a blood group H antibody (BGH).
MUC5AC:WGA
A glycoform of MUC5AC bound to the plant lectin wheat germ agglutinin (WGA).
NELL1
NELL1 is a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth …
p16
From NCBI Gene: This gene (CDKN2A) generates several transcript variants which differ in their first exons. At least three alternatively spliced variants …
PGC
From NCBI Gene: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in …
PIK3CA
From NCBI Gene: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene …
PTEN
From NCBI Gene: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene …
REG1A
REG1 is a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic …
REG3A
REG3 is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The …
RUNX3
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to …
SCCAIC
SCCAIC, squamous cellular carcinoma antigen (SCCA) immunocomplexed with IgM, has been proposed as an alternative marker. Squamous cell carcinoma antigen (SCCA) …
SERPINA1
Alpha-1-antitrypsin is secreted and is an extracellular serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and …
SERPINB3
Squamous cell carcinoma antigen (SCCA) may act as a protease inhibitor to modulate the host immune response against tumor cells. Present in the cytoplasm of …
SFRP1
From NCBI Gene: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled …
SLIT2
From NCBI Gene: This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. …
SOX17
From NCBI Gene: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development …
SST
The hormone somatostatin (SST) has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. …
sTRA
sTRA is a sialylated version of the TRA antigen. It is a carbohydrate antigen produced by some cancer cells.
TAC1
The tachykinin gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide …
TFPI
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the …
TIMP1
The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in …
TMEFF2
HPP1 (also called TMEFF2) may be a survival factor for hippocampal and mesencephalic neurons. The shedded form (generated by proteolytic shedding) up-regulates …
TNC
From NCBI Gene: This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric …
TNFRSF6B
DcR3 belongs to the tumor necrosis factor receptor superfamily and is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. …
TP53
TP53, also widely known as p53, acts as a tumor suppressor in many tumor types, responding to diverse cellular stresses to regulate target genes that induce …
VHL
From NCBI: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A …

Projects

A Biomarker Bakeoff in Early Stage Pancreatic Cancer
Previous research in EDRN laboratories and elsewhere has produced several candidate biomarker(s) for the detection of early-stage pancreatic ductal …
Biomarkers for early detection of pancreatic cancer
To identify biomarkers of preclinical pancreatic cancer
Biomarkers for the Early Detection of Pancreatic Cancer
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)
The goal of this project is to evaluate biomarkers in normal colonic mucosa to determine their relationship to the occurrence of short- and long-term …
Colon Reference Set Application: Robert Getzenberg - Johns Hopkins (2008)
The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and …
Colon Reference Set Application: Moncef Jendoubi - Milagen (2006)
Confidential
Colon Reference Set Application: Mary Disis - University of Washington (2008)
The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a …
Colon Reference Set Application: Nam Kim - DiaDexus (2008)
The EDRN Colorectal reference samples will be useful in confirming the potential application of novel serum markers for colorectal cancer that can detect …
Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers
Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer
Hollingsworth - Aggressive vs Indolent 2012
We will examine DNA extracted from FFPE sections from approximately 200 different surgically resected primary pancreatic tumors from the UNMC Department of …
Liver Cancer Reference Set Application (Rapid): Chilkoti (2019)
Liver Full Reference Set Application: Hiro Yamada - Wako (2011)
Wako has received new 510(k) clearance for Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) and Des-gamma-carboxy prothrombin (DCP) …
Liver Full Reference Set Application: David Lubman - Univ of Michigan (2011)
In this work we will perform the next step in the biomarker development and validation. This step will be the Phase 2 validation of glycoproteins that have …
Liver Rapid Reference Set Application: Villanueva Mt Sinai-Icahn (2019)
Liver Rapid Reference Set Application (#2): Laura Beretta-FHCRC (2011)
Test 2 candidate biomarkers for early detection of HCC. Marker S and Marker L.
Liver Rapid Reference Set Application: Hemken - Abbott (2015)
The aim for this testing is to find a small panel of biomarkers (n=2-5) that can be tested on the Abbott ARCHITECT automated immunoassay platform for the early …
Liver Rapid Reference Set Application: Gary Norman-INOVA (2012)
We have developed a new and novel assay for the detection of Golgi protein 73 (GP73), also known as Golgi membrane protein 1 (Golm1) or Golgi phosphoprotein 2 …
Liver Reference Set-Rapid-Application: Nilsson Glycobond (2018)
Pancreatic Cyst Biomarker Validation Study
With the rapid utilization and ongoing advancements in cross-sectional abdominal imaging, the detection of pancreatic cysts has become increasingly frequent. …
Pancreatic Cystic Fluid Reference Set
The proposed reference set will be designed to evaluate biomarkers for the following applications aimed at determining whether a patient would benefit from …
Pancreatic Reference Set Application:Sumio Ohtsuki/Kazfumi Honda-Kumamoto University (2019)
Pancreatic Reference Set Application: Ivan Blasutig-University of Toronto (2014)
The primary objective of this study is to independently validate a panel of serum biomarkers for the early detection of pancreatic ductal adenocarcinoma …
Pancreatic Reference Set Application: Michael Hollingsworth-University of Nebraska (2014)
Pancreatic Reference Set Application: Surinder Batra- University of Nebraska (2014)
To explore the diagnostic significance of the most differentially overexpressed secretory mucin MUC4 and MUC5AC for early detection
Pancreatic Reference Set Application: Samir Hanash-MD Anderson (2017)
Pre-diangtic Pancreatic Cancer Set Aside Project
For the early detection of pancreatic cancer, screening among the general population is not feasible due to low prevalence of the disease in general …
Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)
the goal of identifying those biomarkers developed by the GI collaborative that will predict the presence of advanced colorectal adenomas.
Standard Specimen Reference Set: Liver
Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC
Standard Specimen Reference Set: Colon
The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, …
Standard Specimen Reference Set: Pancreatic
The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens …
Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis
Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict …
Using the methylome to identify aggressive Barrett’s esophagus
OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that …

Protocols

A Prospective Study to Establish a New Onset Hyperglycemia and Diabetes (NOD) Cohort
Affinity-based strategies to fast track development of colon cancer biomarkers
Our goal is to discover plasma and tissue-based tumor biomarkers that work well enough together to identity colon cancer at early stages, lead to accurate …
Barrett's Esophagus Methylation Profiles
We propose a nested case-control study of biomarkers in the setting of BE. By bringing together research institutions with large populations of patients with …
Clinical and Analytical Validation of Cancer Biomarkers: Developmental Studies
Detection of cancer DNA markers in urine
Development of Tissue Microarray Resource for Pancreatic Cancer
Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is the 3rd most common cause of cancer deaths in the United States and is projected by 2030 to be …
Early detection of liver cancer and hepatitis
Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies
Determining and quantifying the types of mucin core proteins to which CA19-9 is attached will result in assays with improved performance characteristics …
EDRN-WHI Pre-Clinical Colon Ca Specimens
Specifically, it is proposed to assess plasma proteins from postmenopausal women diagnosed with colon cancer within a span of 18 months after year-3 OS blood …
Evaluating DNA Damage and DNA Repair Capacity as Biomarkers of Non- Indolent Prostate Cancer
Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas Great Lakes New England (GLNE) Clinical Validation Center
GLNE 003: Preliminary Validation of Biomarkers Predictive of Barrett’s Esophagus Progression to Dysplasia and Adenocarcinoma
   Recognizing that novel potential biomarkers are continually being identified and will need to be validated in a rapid, efficient, and scientifically …
Hepatocellular carcinoma Early Detection Strategy study
Part 1: The first part of this study is to conduct follow-up for patients that were enrolled in the EDRN Phase 2 Validation Study called DCP (13). For this …
Hereditary Cancer Institute family study specimen bank
HNPCC colon cancer-associated SELDI mass spectrometry protein profiles in serum
Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia
Liver Full Reference Set Application :Timothy Block - Drexel Univ (2010)
The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular …
Liver Rapid Reference Set Application: Hiro Yamada - Wako (2011)
Measure clinical effectiveness of AFP-L3 and DCP for early detection of HCC in patient samples collected prospectively during surveillance. However since such …
Liver Rapid Reference Set Application: Gianluigi Giannelli - Univ of Bari (2008)
To evaluate biomarker performance in an out-side cohort of LC and HCC patients
Liver Rapid Reference Set Application (#1): Laura Beretta-FHCRC (2011)
Test 2 candidate biomarkers for early detection of HCC. Marker S and Marker L.
Liver Rapid Reference Set Application: Kevin Qu-Quest (2011)
We propose to evaluate the performance of a novel serum biomarker panel for early detection of hepatocellular carcinoma (HCC). This panel is based on markers …
Liver Rapid Reference Set Application (#1): David Lubman - Univ of Michigan (2009)
We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC …
Liver Rapid Reference Set Application ( #2): Lubman - Univ of Michigan (2010)
We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC …
Liver Rapid Reference Set Application: Timothy Block - Drexel Univ (2008)
The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular …
Methylation tumor markers in HNPCC
MMR protein expression in HNPCC
Molecular Basis of Barrett's -Associated Carcinogenesis
Mutational load distribution analysis (MLDA) in pancreatic cancer
Certain p16 mutation carriers showed mutation elevations in the specific Ki-ras and p53 alleles significantly higher than normal, similar to controls with …
Novel Surveillance Strategies For Hereditary Nonpolyposis Colon Cancer Family Members
Pancreatic Cancer Bake Off 2
The GI collaborative team project from the previous year had the goal of performing a rigorous evaluation of multiple candidate biomarkers using a common …
Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside)
Pancreatic Reference Set Application: Brian Haab-Van Andel (2012)
New markers are greatly needed for the detection and diagnosis of pancreatic cancer. Patients at high risk for developing pancreatic cancer (for, example …
Pancreatic Reference Set Application- Ann Killary and Subrata Sen-MD Anderson (2012)
ELISA assays. We propose to screen a two gene panel (TNC/TFPI) from functional genomic pathways approaches, by ELISA assays, in a collection of blinded plasma …
Pancreatic Reference Set Application: Kazufumi Honda-National Cancer Center (2014)
Among human malignancies, invasive ductal adenocarcinoma of the pancreas has the worst prognosis,with a 5-year survival rate of less than 10%. Most patients …
Polyp Prediction Study
Preliminary Clinical Characterization of Serum Biomarkers for Colorectal Neoplasms
Prevalidation for Rectal PWS for Colon Cancer Screening
Prognostic Markers in Lynch Syndrome Colorectal Cancers
Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers
Screen Detection of Mismatch Repair Deficient Colorectal Neoplasias Using a Stool Based DNA Analysis
Spectral Markers for Early Detection of Colon Neoplasia
Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010)
We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia …
Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma
Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early …

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