A high-stringency blueprint of the human proteome.

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Adhikari S, Aebersold R, Ahn SB, Bairoch A, Baker MS, Bandeira N, Chan DW, Corrales FJ, Cristea IM, Deutsch EW, Domont GB, Gundry RL, He F, Justice JL, Kostrzewa M, Kusebauch U, LaBaer J, Lam MPY, Lane L, Lindskog C, Lundberg E, Marko-Varga G, Moritz RL, Nice EC, Nogueira FCS, Omenn GS, Overall CM, Paik YK, Palmblad M, Pennington SR, Pineau C, Ping P, Rodriguez H, Schwenk JM, Snyder MP, Srivastava S, Srivastava S, Stewart P, Uhlén M, Van Eyk JE, Vandenbrouck Y, Vizcaino JA, Waddington JC, Weintraub ST, Wennersten S, Wilkins M

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Nat Commun, 2020, 11 (1)

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