BAP1: role in carcinogenesis and clinical implications.
BRCA-1 associated protein 1 (<i>BAP1</i>) is a tumor suppressor gene that has been implicated in the pathogenesis of several malignancies and is gaining more recognition as a crucial gene that could be amenable to therapeutic manipulation. There is a growing interest in prevention and establishing cancer screening guidelines in patients with germline <i>BAP1</i> mutations to aid with early detection and treatment of associated malignancies. We aim to give a concise review of <i>BAP1</i> and its role in carcinogenesis, the <i>BAP1</i> cancer predisposition syndrome and discuss clinical implications including suggested screening guidelines, and potential targeted therapeutic options.
- Kittaneh M
- Kobrinski DA
- Yang H