Team Project

Ovarian Cancer Screening Pilot Trial In High Risk Women

Ovarian Cancer Screening Pilot Trial In High Risk Women
Lynch, HenryCreighton University

No coordinating investigator defined.

No design specified.
Breast and Gynecologic Cancers Research Group

This screening study includes women with high quantified risk of having a BRCA1/2 mutation, as well as women with a confirmed BRCA1/2 mutation. This trial permits initial estimation of the incidence of ovarian cancer by age and menopausal status. Subjects were screened for a minimum of one year and followed for up to one year. Estimates of CA-125 values over time would provide the basis for refining the "risk of ovarian cancer algorithm" (ROCA) more accurately to high risk women and provide guidance for clinical interpretation of CA-125 tests in sub-groups (pre/post menopausal status, estrogen replacement therapy Y/N, and prophylactic oophorecomty Y/N).

To bring EDRN participation into the CGN study of early detection of ovarian cancer in high risk women using serum and plasma markers. This is a project with Stephen Skates, Ph.D. (Massachusetts General Hospital, MGH Biostatistics Center) “Ovarian cancer screening pilot trial in high risk women”. We will recruit 30 women for this trial.

There are currently no biomarkers annotated for this protocol.

No datasets are currently associated with this protocol.

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