Development of Tissue Microarray Resource for Pancreatic Cancer

Pancreatic TMA
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Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is the 3rd most common cause of cancer deaths in the United States and is projected by 2030 to be the 2nd leading cause of death from cancer. Current strategies focus on improving patient survival by both diagnosing PDAC at an earlier stage when curative resection is still feasible and improving the current approach to oncologic treatment. Advancing early detection of PDAC through fluid-based biomarker development, such as pancreatic cyst fluid and plasma samples, has been a central goal of the Early Detection Research Network (EDRN) and the subject of two team-based funded projects: (1) The Pancreatic Cyst Biomarker Validation Study and (2) The Biomarker Bakeoff in Early Stage Pancreatic Cancer. As these projects are nearing completion, additional studies are being organized to assess assay performance, biomarker optimization and the inclusion of other, promising biomarkers from EDRN and non-EDRN investigators. However, the lack of corresponding formalin-fixed, paraffin-embedded (FFPE) tissue specimens to complement pancreatic cyst fluid and plasma samples limits the capability of biomarker assay refinement. The overall goal of this proposal is to supplement ongoing EDRN team-based projects by creating a large series of tissue microarrays (TMAs) from corresponding surgically resected pancreatic cysts and early-stage PDACs. Additional goals include the creation of supplementary TMAs and an integrated system for TMA disbursement to both EDRN and non-EDRN investigators.

Aim 1: To create a tissue microarray resource of EDRN team-based pancreatic cyst and early-stage pancreatic ductal adenocarcinoma projects (Timeframe: 12 months). Aim 2: To create a series of tissue microarrays of pancreatic cyst and pancreatic ductal adenocarcinoma separate from EDRN team-based projects for biomarker optimization and validation studies (Timeframe: 12 months)

There are currently no biomarkers annotated for this protocol.

No datasets are currently associated with this protocol.


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