Evaluation of emerging tissue-based biomarkers for aggressive prostate cancer in men on active surveillance

Abbreviated Name
NGS-Oncomine Panel
Lead Investigator
Mosquera, Juan MiguelWeill Cornell Medical College-Central Review
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators


No abstract availalbe.


This is a sub-project of the GHI Collaboration Project (PASS Project Reference Set ID 417). The Prostate Active Surveillance Study Consortium (PASS) will provide approximately 715 formalin-fixed paraffin-embedded diagnostic biopsy specimens to Genomic Health, Inc. (GHI) for use in the collaborative study entitled “Molecular Markers for the Prediction of Disease Progression in Men with Clinically Localized Prostate Cancer on Surveillance in the Canary Prostate Active Surveillance Study (PASS)” (the “PASS GHI Study”). Specimens will be shipped to GHI in batches of 50. For the conduct of the PASS GHI Study, 8 x 5µm tumor sections will be made from the formalin-fixed paraffin-embedded biopsy specimens For the research study described here an additional 7 × 5µm sections will be made from the same tumor blocks used to isolate RNA for Oncotype DX validation. These additional sections will be used for the extraction of tumor DNA. Manual dissection may be used to enrich for tumor tissue followed by DNA extraction, both performed at GHI. All extracted tumor DNA will be sent from GHI to Dr. Mark Rubin at Weill Cornell Medical College (WCMC) for evaluation of novel tissue-based biomarkers for prediction of aggressive prostate cancer, Aim 2 of Dr. Rubin’s grant listed above. The research results from Dr. Rubin’s work will be analyzed with the PASS clinical data at the PASS Data Management and Coordinating Center located at the Fred Hutchinson Cancer Research Center.

Analytic Method

No analytic method available.


  • No publications available at this time for this protocol.


  • No biomarkers available at this time for this protocol.

Data Collections

  • No data collections available at this time for this protocol.
Start Date
Jan 1 2015
Protocol ID
Protocol Type
Field of Research
Collaborative Group
Prostate and Urologic Cancers Research Group
Cancer Types
  • Malignant neoplasm of prostate

Associated Forms