Abbreviated Name

Liver CA Ref Set App (Rapid): Chilkoti (2019)

Lead Investigator

Chilkoti, Ashutosh — Duke University

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Chilkoti, Ashutosh — Duke University

Abstact

See objectives

Aims

See Objectives

Analytic Method

We will analyze 100 samples from the reference set (50 early stage HCC cases and 50 at risk of HCC with liver disease (cirrhotic). Samples will be analyzed in parallel on 6-plex D4 POCT chips and standard ELISA kits to directly compare the analytical performance between the two. All test points will be run in triplicate. The assay will be evaluated in terms of the following “figures-of-merit” (FOM): limit-of-blank (LOB), limit-of-detection (LOD; synonymous with ‘analytical sensitivity’), linear calibration range (LCR), upper and lower limits of quantification (LOQ) and coefficient-of-variance (COV).

Biomarkers

• AFP
• DKK1
• Osteopontin

Data Collections

• No data available at this time for this protocol

 Team Project

Protocol ID

457

Field of Research

Proteomics

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Liver cell carcinoma

Phased Status

1