Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas Great Lakes New England (GLNE) Clinical Validation Center

Lead Investigator: Brenner, Dean — University of Michigan

Coordinating Investigator: Feng, Ziding — Fred Hutchinson Cancer Research Center

Involved Investigator Sites:

• Syngal, Sapna — Dana Farber Cancer Institute-BWH
• Symonds, Erin — Flinders Centre for Innovation in Cancer
• Feng, Ziding — Fred Hutchinson Cancer Research Center
• Ruffin, IV, Mack T. — Hershey-Penn State Medical Center
• Teshima, Christopher — St Michael's Hospital
• Bresalier, Bob — The University of Texas MD Anderson Cancer Center
• Brenner, Dean — University of Michigan
• Stoffel, Elena — University of Michigan
• McConnell, Daniel S. — University of Michigan
• Church, Tim R — University of Minnesota
• Baron, John A. — University of North Carolina
• Grady UW, William — University of Washington
• Young, Graeme — Lab – Flinders Centre for Innovation in Cancer

Biomarker Name: Circulating methylated genes BCAT1/IKZF1 (Clinical Genomics). Hypomethylated LINE1 from circulating cell free DNA (VolitionRx)

Design: No design specified.

Field(s) of Research: UNKNOWN

Collaborative Group: G.I. and Other Associated Cancers Research Group

Phased Status: 1

Aims:

Analytic Method:

Comments:

Biomarkers:

• TIMP1
• BCAT1
• IKZF1
• Hypomethylated LINE1 from circulating cell free DNA (VolitionRx)
• Circulating methylated genes BCAT1/IKZF1 (Clinical Genomics)
• galectin-3 ligand

Datasets:

No datasets are currently associated with this protocol.