Abbreviated Name

PASS Ref Set App: Lin (2010) TMPRSS2-ERG

Lead Investigator

Lin UW, Daniel W. — University of Washington

Coordinating Investigator

No coordinating investigator

Involved Investigators

• Groskopf, Jack — Hologic Gen-Probe Incorporated
• Lin UW, Daniel W. — University of Washington

Abstact

No abstract availalbe.

Aims

1.   Assess the frequency of TMPRSS2:ERG gene-fusion in whole urines of an active surveillance population. 2.   Evaluate urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression. 3.   Evaluate longitudinal changes in urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression.

Analytic Method

Gen-Probes TMA assay

Outcome

Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.

Publications

• Urinary TMPRSS2:ERG and PCA3 in an active surveillance cohort: results from a baseline analysis in the Canary Prostate Active Surveillance Study.

Biomarkers

• PCA3
• TMPRSS2:ERG

Data Collections

• No data collections available at this time for this protocol.

Start Date

Jun 30 2010

Finish Date

Mar 20 2013

Protocol ID

368

Protocol Type

Reference Set

Field of Research

Proteomics

Collaborative Group

Prostate and Urologic Cancers Research Group

Cancer Types

• Malignant neoplasm of prostate

Phased Status

2