Breast Reference Set Application: GeorgeTuszynski-Temple (2012)

Abbreviated Name
Breast Ref Set App: Tuszynski (2012)
Lead Investigator
Tuszynski, GeorgeTemple University
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators


No abstract availalbe.


We are addressing the question of whether G-protein coupled receptor-associated sorting protein 1 (GASP-1) initially discovered in the serum of breast cancer patients can be used as a serum biomarker for the early detection, diagnosis or prognosis of breast cancer.

Analytic Method

We will use logistic regression to test if GASP-1 is associated with case-control status after adjustment for age and body mass index. As described in the breast cancer reference set description document, with sample size of 30 cases and 30 controls the study has excellent power for a positive result if the marker is associated with breast cancer (OR=5 for a dichotomized version of the marker). An age-adjusted ROC curve and AUC for the GASP-1 marker will be calculated along with bootstrap confidence limits


  • No publications available at this time for this protocol.


Data Collections

  • No data collections available at this time for this protocol.
Finish Date
Dec 4 2018
Protocol ID
Protocol Type
Reference Set
Field of Research
Collaborative Group
Breast and Gynecologic Cancers Research Group
Cancer Types
  • Malignant neoplasm of breast

Associated Forms