Colon Reference Set Application: Mary Disis - University of Washington (2008)
- Abbreviated Name
- Colon Ref Set App: Disis (2008)
- Lead Investigator
- Disis, Mary L — University of Washington
- Coordinating Investigator
- Disis, Mary L — University of Washington
- Involved Investigators
Abstact
Aims
To validate the diagnostic value of a panel of serum antibodies (cathepsin D, p53, cyclin B1, topoisomerase IIalpha, IGFBP2, CEA) for the early detection of colorectal cancer.
Analytic Method
We will run ELISA blinded to case status, data along with our prediction of disease status for each sample, will be sent to EDRN-DMCC at Fred Hutchinson Cancer Research Center for statistical analysis. DMCC already has the combination role from our preliminary study. Our preliminary data suggested that at high specificity 90%, sensitivity is 57%. With n=50 in each group, we have more than 80% power to confirm this level of sensitivity against an inferior sensitivity of 37% at 90% specificity comparing CRC versus normal controls. We understand that the reference set is not powered for definitive validation but to help prioritization. We did not have the data on patients with adenoma but the performance on early-stage CRC suggests that it is possible our marker panel could detection early lesions like adenoma,
Comments
Goodell V, Lu H, Delong J, Disis ML. Antibody Immunity to a Panel of Oncogenic Proteins May Predict Presence of Colorectal Cancer and Stage of Disease. Manuscript in preparation.
Biomarkers
Data Collections
- No data available at this time for this protocol
Team Project
- Protocol ID
- 249
- Protocol Type
- Reference Set
- Field of Research
- Proteomics
- Collaborative Group
- G.I. and Other Associated Cancers Research Group
- Cancer Types
-
- Malignant neoplasm of colon