Abbreviated Name

LIVER REF

Lead Investigator

Parikh, Neehar — University of Michigan

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Schwartz, Myron — Mount Sinai Hospital
• Befeler, Alex — Saint Louis University
• Roberts, Lewis — Mayo Clinic
• Nguyen, Mindie — Stanford University
• Parikh, Neehar — University of Michigan
• Srivastava, Sudhir — National Cancer Institute
• Reddy, Rajender — University of Pennsylvania

Abstact

Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC

Aims

Specific Aims Aim 1: To determine the sensitivity and specificity of des-gamma carboxyprothrombin (DCP) for the diagnosis of early hepatocellular carcinoma (HCC). Aim 2: To compare the accuracy of DCP and Alpha-fetoprotein (AFP) for the diagnosis of early HCC. Aim 3: To determine whether demographic or etiology of underlying liver disease alter the expression of DCP or AFP.

Analytic Method

N/A

Biomarkers

• No biomarkers available at this time for this protocol

Data Collections

• No data available at this time for this protocol

 Team Project

Protocol ID

134

Field of Research

Other, Specify

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Liver cell carcinoma