Aliases

• ACT1
• C6orf2
• C6orf4
• C6orf5
• C6orf6
• CIKS
• Connection to IKK and SAPK/JNK
• DKFZP586G0522
• NFkB-activating protein ACT1
• Nuclear factor NF-kappa-B activator 1
• PSORS13
• TRAF3 interacting protein 2
• TRAF3-interacting protein 2
• TRAF3IP2
• adapter protein CIKS
• chromosome 6 open reading frame 2
• chromosome 6 open reading frame 5
• connection to IKK and SAPK/JNK
• nuclear factor NF-kappa-B activator 1

Description

From NCBI Gene: This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Attributes

QA State

Under Review

Type

Gene

HGNC Name

TRAF3IP2