PTPN11
- Aliases
-
- BPTP3
- CFC
- EC 3.1.3.48
- NS1
- Noonan syndrome 1
- PTP-1D
- PTP-2C
- PTP2C
- PTPN11
- Protein-tyrosine phosphatase 1D
- Protein-tyrosine phosphatase 2C
- SH-PTP2
- SH-PTP3
- SHP-2
- SHP2
- SHPTP2
- Shp2
- protein tyrosine phosphatase, non-receptor type 11
- protein-tyrosine phosphatase 1D
- protein-tyrosine phosphatase 2C
- tyrosine-protein phosphatase non-receptor type 11
- Description
- PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTP family members are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. The activity of PTPs opposite that of kinases and phosphorylases and therefore PTPs play an integral role in many signal transduction pathways. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN11 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- PTPN11
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.