Aliases

• 16.3A5
• 1F5 antigen
• 20 kDa homologous restriction factor
• CD59
• CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
• CD59 antigen, complement regulatory protein
• CD59 glycoprotein
• EJ16
• EJ30
• EL32
• G344
• HRF-20
• MAC-IP
• MAC-inhibitory protein
• MACIF
• MEM43 antigen
• MIC11
• MIN1
• MIN2
• MIN3
• MIRL
• MSK21
• Membrane attack complex inhibition factor
• Membrane inhibitor of reactive lysis
• Protectin
• p18-20

Description

From NCBI Gene: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

CD59