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Biomarkers
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
ACO1
aconitase 1, soluble
ACSL3
acyl-CoA synthetase long-chain family member 3
ACTC1
actin, alpha, cardiac muscle 1
ACY1
aminoacylase 1
AGR2
anterior gradient 2 homolog (Xenopus laevis)
AGTPBP1
ATP/GTP binding protein 1
AHNAK2
AHNAK nucleoprotein 2
ALDH1A2
From NCBI Gene: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of ...
AMACR
AMACR, a racemase, is an enzyme that interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the ...
AMD1
adenosylmethionine decarboxylase 1
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD40
ankyrin repeat domain 40
ANXA2
ANXA2, a member of the annexin family, is a calcium-dependent phospholipid-binding protein that plays a role in the regulation of cellular growth and in signal ...
ANXA3
annexin A3
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
APC
The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell ...
APOLD1
From NCBI Gene: APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function ...
ARHGDIA
From NCBI Gene: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the ...
ARHGEF40
From NCBI Gene: This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a ...
ARID5A
From NCBI Gene: Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, ...
ATF3
ATF3 is a member of the the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. The ATF3 ...
AUH
From NCBI Gene: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a ...
AZGP1
From UniProt/SwissProt: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind ...
BCHE
From NCBI Gene: This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits ...
BCL2L14
From NCBI Gene: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or ...
BDNF
BDNF (brain-derived neurotrophic factor) is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of ...
BHMT2
From NCBI Gene: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to ...
BIN1
From NCBI Gene: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein ...
BPSA
From PMID:18550118: A degraded form of PSA with internal peptide bond cleavages associated with benign prostatic hyperplasia and the transition zone of the ...
BTN2A1
From NCBI Gene: This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the ...
C1QBP
From NCBI Gene: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The ...
C6orf62
C6orf62 is an uncharacterized protein.
C7
From NCBI Gene: This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of ...
CA15-3
From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role ...
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker ...
CALR
From NCBI Gene: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It ...
CAND2
From UniProtKB/Swiss-Prot: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the ...
CAV1
From NCBI Gene: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links ...
CBX4
From UniprotKB/Swiss-Prot: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a ...
CCDC69
coiled-coil domain containing 69
CCDC90A
coiled-coil domain containing 90A
CCDC91
coiled-coil domain containing 91
CCL18
CCL18, also known as MIP-4, is a member of the cytokine family, a family of secreted proteins involved in immunoregulatory and inflammatory processes. ...
CCL20
chemokine (C-C motif) ligand 20
CCNG2
cyclin G2
CD164
CD164 molecule, sialomucin
CD177
CD177 molecule
CD24
CD24 molecule
CD2AP
CD2-associated protein
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
CDH1
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein ...
CDK16
cyclin-dependent kinase 16
CDK7
From NCBI Gene: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the ...
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5
From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the ...
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
CFB
complement factor B
CHN2
chimerin 2
CLDN8
claudin 8
CLIP3
CAP-GLY domain containing linker protein 3
COL4A2
collagen, type IV, alpha 2
CP
ceruloplasmin (ferroxidase)
CPB1
carboxypeptidase B1 (tissue)
CPM
carboxypeptidase M
CRTAC1
CRTAC1, a secreted protein, is expressed in the interterritorial matrix of articular deep zone cartilage. There are three isoforms for CRTAC1; isoform 1, ...
CRTC3
CREB regulated transcription coactivator 3
CSDC2
cold shock domain containing C2, RNA binding
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK2A1
casein kinase 2, alpha 1 polypeptide
CSPG4
chondroitin sulfate proteoglycan 4
CTIF
CBP80/20-dependent translation initiation factor
CXADR
coxsackie virus and adenovirus receptor
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2
chemokine (C-X-C motif) ligand 2
CXCL5
chemokine (C-X-C motif) ligand 5
CXCL8
CXCL8, commonly known as IL8, is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that ...
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
DAAM2
dishevelled associated activator of morphogenesis 2
DBN1
drebrin 1
DGLUCY
Previously known as C14orf159, the protein product of this gene has been shown by similarity to be a D-glutamate cyclase that converts D-glutamate to ...
DLG3
discs, large homolog 3 (Drosophila)
DMPK
dystrophia myotonica-protein kinase
DMWD
dystrophia myotonica, WD repeat containing
DMXL1
Dmx-like 1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC15
DnaJ (Hsp40) homolog, subfamily C, member 15
DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
DPP4
dipeptidyl-peptidase 4
DPYSL3
dihydropyrimidinase-like 3
DSG2
DSG2 is a calcium-binding transmembrane glycoprotein component of intercellular desmosome junctions in vertebrate epithelial cells. It is involved in the ...
DUSP22
dual specificity phosphatase 22
DYSF
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
EAF2
ELL associated factor 2
EFCAB14
EF-hand calcium binding domain 14
EFEMP1
EFEMP1, also known as fibulin-3, binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. It ...
EHF
ets homologous factor
EIF5A
eukaryotic translation initiation factor 5A
ELF5
E74-like factor 5 (ets domain transcription factor)
ELOVL2
ELOVL fatty acid elongase 2
ENO2
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
EPM2A
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
ERG
The ERG gene codes for the ERG protein, a transcription factor that is a member of the erythroblast transformation-specific (ETS) family of transcriptions ...
EXOSC2
exosome component 2
FADS2
fatty acid desaturase 2
FAIM2
Fas apoptotic inhibitory molecule 2
FAM131B
family with sequence similarity 131, member B
FAM55D
neurexophilin and PC-esterase domain family, member 4
FBLN1
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its ...
FBXO9
F-box protein 9
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FERMT2
fermitin family member 2
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
FHL1
four and a half LIM domains 1
FHL3
four and a half LIM domains 3
FHOD3
formin homology 2 domain containing 3
FKBP11
FK506 binding protein 11, 19 kDa
FLNA
From NCBI Gene: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane ...
FLNC
filamin C, gamma
FMO5
flavin containing monooxygenase 5
FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
FOLH1B
FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related ...
FOXD1
forkhead box D1
FTH1P5
ferritin, heavy polypeptide 1 pseudogene 5
FXYD6
FXYD domain containing ion transport regulator 6
G3BP1
GTPase activating protein (SH3 domain) binding protein 1
GADD45A
growth arrest and DNA-damage-inducible, alpha
GADD45B
growth arrest and DNA-damage-inducible, beta
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
Garcia chromosomal aneusomy + cytology
Fluorescence in situ hybridization (FISH) assay is used to monitor levels of chromosome copies in interphase cells. Multicolor FISH proes simultaneously ...
GEM
GTP binding protein overexpressed in skeletal muscle
GGT1
gamma-glutamyltransferase 1
GLDC
glycine dehydrogenase (decarboxylating)
GLRX
glutaredoxin (thioltransferase)
GLUD1
glutamate dehydrogenase 1
GNB5
guanine nucleotide binding protein (G protein), beta 5
GOLM1
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi ...
GPM6B
GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is ...
GPNMB
glycoprotein (transmembrane) nmb
GSTA1
glutathione S-transferase alpha 1
GSTP1
Glutathione S-transferases are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and ...
HIST1H1C
histone cluster 1, H1c
HIST1H2BC
From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of ...
HIST1H2BE
H2B histone family, member H
HIST1H2BF
histone cluster 1, H2bf
HIST1H2BG
histone cluster 1, H2bg
HIST1H2BH
histone cluster 1, H2bh
HIST1H2BI
histone cluster 1, H2bi
HLA-G
major histocompatibility complex, class I, G
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPL
heterogeneous nuclear ribonucleoprotein L
HOXA4
homeobox A4
HOXA5
homeobox A5
HOXA9
HOXA9 is a sequence-specific transcription factor. It is a member of the homeobox gene family. These transcription factors are spatially and temporally ...
HOXB13
homeobox B13
HPD
4-hydroxyphenylpyruvate dioxygenase
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
HSPA12A
heat shock 70kDa protein 12A
HSPB1
heat shock 27kDa protein 1
HSPB6
heat shock protein, alpha-crystallin-related, B6
HSPB8
From NCBI Gene: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at ...
IGF1
insulin-like growth factor 1 (somatomedin C)
IGFBP6
insulin-like growth factor binding protein 6
IHC and FISH for T2-ERG fusion
IHC and FISH for T2-ERG fusion.
IQCB1
IQ motif containing B1
IRF9
interferon regulatory factor 9
ITGA5
From NCBI Gene: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an ...
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1
From NCBI Gene: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor ...
JMJD6
jumonji domain containing 6
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
KCTD17
potassium channel tetramerisation domain containing 17
KIAA1467
KIAA1467
KIF3C
kinesin family member 3C
KLC1
kinesin light chain 1
KLF5
Kruppel-like factor 5 (intestinal)
KLK11
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases ...
KLK2
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. The glandular kallikrein gene family comprises 25 ...
KLK4
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases ...
KPNA6
karyopherin alpha 6 (importin alpha 7)
KRT19
KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. ...
KRT7
keratin 7
L1CAM
L1 cell adhesion molecule
LARP6
La ribonucleoprotein domain family, member 6
Laxman 7-marker panel for prostate cancer
This 7-marker multiplex panel of urine transcripts outperforms PCA3 transcript alone for the detection of prostate cancer. The panel consists of PCA3, AMACR, ...
LCN2
lipocalin 2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
LDAH
Previously known as C2orf43, the protein product of this gene is lipid droplet associated hydrolase. From UniprotKB/SwissProt: Serine lipid hydrolase ...
LEPR
leptin receptor
LGALS8
lectin, galactoside-binding, soluble, 8
LIMS2
LIM and senescent cell antigen-like domains 2
LMNA
lamin A/C
LMO3
LIM domain only 3 (rhombotin-like 2)
LMOD1
leiomodin 1 (smooth muscle)
LPIN1
lipin 1
LTBP4
latent transforming growth factor beta binding protein 4
LTF
lactotransferrin
LYPLA1
lysophospholipase I
MAL
mal, T-cell differentiation protein
MAOB
monoamine oxidase B
MAP1A
microtubule-associated protein 1A
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
MCAM
From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its ...
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
MED21
mediator complex subunit 21
Mercola 7-gene signature for prostate cancer
Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, ...
MFAP5
microfibrillar associated protein 5
MGMT
MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. It repairs alkylated guanine in DNA by ...
MIB1
From NCBI Gene: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded ...
Microsatellite Instability Assay
Microsatellite analysis (MSA) is a promising new technique for the surveillance of bladder cancer. The technology, which permits the separation by ...
MiPS (Mi Prostate Score Urine test)
The MiPS assay is a multiplex analysis of T2-ERG gene fusion, PCA3, and serum PSA (KLK3). It is commercially available through the University of Michigan ...
Mitochondrial Genome Deletion for Detection of Prostate Cancer
The Prostate Core Mitomic Test™ is based upon a 3.4 kb mitochondrial genome deletion (3.4 mtdelta) that was identified through PCR analysis of frozen ...
MKI67
From NCBI Gene: This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript ...
MLX
MLX, MAX dimerization protein
MMP10
From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, ...
MMP28
matrix metallopeptidase 28
MMRN2
multimerin 2
MPPED2
MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). ...
MPZ
myelin protein zero
MPZL2
The EVA1, or MPZL2 gene is expressed in the thymus and in several epithelial structures early in embryogenesis. The protein MPZL2 displays an ability to ...
MSRA
methionine sulfoxide reductase A
MSX2
msh homeobox 2
MTA1
From NCBI Gene: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell ...
MTMR11
myotubularin related protein 11
MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
MXRA7
matrix-remodelling associated 7
MZT2A
mitotic spindle organizing protein 2A
NCS1
neuronal calcium sensor 1
NEK3
NIMA-related kinase 3
NKX3-1
NK3 homeobox 1
NLRP1
NLR Family, Pyrin Domain Containing 1
NR4A1
nuclear receptor subfamily 4, group A, member 1
NR4A3
nuclear receptor subfamily 4, group A, member 3
NRIP2
nuclear receptor interacting protein 2
NRXN1
neurexin 1
NT5E
5'-nucleotidase, ecto (CD73)
NXN
nucleoredoxin
NXT1
NTF2-like export factor 1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
OPA1
optic atrophy 1 (autosomal dominant)
ORM1
orosomucoid 1
OSBPL10
oxysterol binding protein-like 10
p14
CDKN2A locus gives rise to 2 distinct transcripts from different promoters: p16 (INK4A) and p14 (ARF). Each has a 5-prime exon which is spliced into common ...
p16
The CDKN2A locus generates several transcript variants which differ in their first exons. Two distinct transcripts are produced from different promoters: p16 ...
PCA3
The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. Because there is no extensive open reading ...
PDCD10
programmed cell death 10
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM4
PDZ and LIM domain 4
PDLIM5
PDZ and LIM domain 5
PDLIM7
PDZ and LIM domain 7 (enigma)
PDZK1IP1
PDZK1 interacting protein 1
PER1
period circadian clock 1
PERP
PERP, TP53 apoptosis effector
PGC
progastricsin (pepsinogen C)
PGCP
carboxypeptidase Q
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
PLN
phospholamban
PLP1
proteolipid protein 1
PNISR
PNN-interacting serine/arginine-rich protein
PPAP2C
phosphatidic acid phosphatase type 2C
PPIF
peptidylprolyl isomerase F
PQBP1
From NCBI Gene: This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW ...
PRMT5
protein arginine methyltransferase 5
PROM1
prominin 1
proPSA
ProPSA (-2), or [-2]proPSA, is a PSA isoform which has a leader peptide (-2) amino acids at its N terminal region and does not interact with ACT or ...
PRPH
peripherin
PRR4
proline rich 4 (lacrimal)
PSA
KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily ...
PSCA
prostate stem cell antigen
PSD3
pleckstrin and Sec7 domain containing 3
PTPRF
protein tyrosine phosphatase, receptor type, F
PTRF
polymerase I and transcript release factor
RAB33B
RAB33B, member RAS oncogene family
RAB3B
RAB3B, member RAS oncogene family
RABEP1
rabaptin, RAB GTPase binding effector protein 1
RARRES1
retinoic acid receptor responder (tazarotene induced) 1
RASSF1
RASSF1A is a potential tumor suppressor. It is required for death receptor-dependent apoptosis and mediates activation of STK4 during Fas-induced apoptosis. ...
RBBP4
retinoblastoma binding protein 4
RBPMS
From NCBI Gene: This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids ...
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RDH16
retinol dehydrogenase 16 (all-trans)
REEP1
receptor accessory protein 1
RET
ret proto-oncogene
RHOQ
ras homolog family member Q
RNF208
ring finger protein 208
RPL13
ribosomal protein L13
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
RRAGD
From NCBI Gene: RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in ...
RRAS2
related RAS viral (r-ras) oncogene homolog 2
RXRG
retinoid X receptor, gamma
S100B
S100 calcium binding protein B
S100P
The S100P protein is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100P is a homodimer, and it interacts with S ...
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like
SCARA3
scavenger receptor class A, member 3
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1
SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is ...
SCNN1A
SCNN1A, a multi-pass membrane protein belonging to the amiloride-sensitive sodium channel family, is a sodium permeable non-voltage-sensitive ion channel ...
SDPR
serum deprivation response
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC2
serine incorporator 2
SERP1
stress-associated endoplasmic reticulum protein 1
SGCA
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
SLC26A4
solute carrier family 26, member 4
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
SLC35C2
solute carrier family 35, member C2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
SLC4A1AP
From GeneCards: SLC4A1AP (Solute Carrier Family 4 Member 1 Adaptor Protein) is a protein coding gene.
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A7
solute carrier family 5 (choline transporter), member 7
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLK
STE20-like kinase
SLPI
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical ...
SOCS3
suppressor of cytokine signaling 3
SOX10
SRY (sex determining region Y)-box 10
SPAC9
SPAC9 is a protein coding gene located on chromosome 9.
SPINK1
SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Its physiological function is to prevent the ...
SQRDL
sulfide quinone reductase-like (yeast)
SRD5A3
steroid 5 alpha-reductase 3
SRP72
signal recognition particle 72kDa
SRSF8
serine/arginine-rich splicing factor 8
ST14
ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this ...
ST5
suppression of tumorigenicity 5
STAT1
signal transducer and activator of transcription 1, 91kDa
STAT2
signal transducer and activator of transcription 2, 113kDa
STBD1
starch binding domain 1
STEAP4
STEAP family member 4
STK38L
serine/threonine kinase 38 like
STOM
STOM, or stomatin, is an integral membrane protein located in the cell membrane of red blood cells and other cell types, where it is thought to regulate ion ...
STT3A
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
STYXL1
serine/threonine/tyrosine interacting-like 1
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
SUSD5
sushi domain containing 5
SVIL
supervillin
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNE3
long intergenic non-protein coding RNA 341
SYNGR1
synaptogyrin 1
TBXA2R
thromboxane A2 receptor
TCEAL2
transcription elongation factor A (SII)-like 2
TCF21
TCF21 is involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. ...
Testosterone
From NCI Thesaurus: A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, ...
TF
TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene ...
TFE3
transcription factor binding to IGHM enhancer 3
TFF3
TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at ...
TGFB1I1
transforming growth factor beta 1 induced transcript 1
TGM4
transglutaminase 4 (prostate)
THBS1
TSP is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP can bind to fibrinogen, fibronectin, laminin, type V collagen ...
THRA
thyroid hormone receptor, alpha
THY1
From NCBI Gene: This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell ...
TMBIM6
transmembrane BAX inhibitor motif containing 6
TMEM251
transmembrane protein 251
TMEM30B
transmembrane protein 30B
TMPRSS2
TMPRSS2 is a member of the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. This gene was ...
TMPRSS2:ERG
TMPRSS2:ERG gene fusions are a common genetic event in prostate cancer. These fusions are specific for prostate cancer and have also been observed ...
TMSB15A
thymosin beta 15a
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
TNFSF12
tumor necrosis factor (ligand) superfamily, member 12
TNS1
tensin 1
TOM1L1
target of myb1 (chicken)-like 1
TOX4
TOX high mobility group box family member 4
TP53
TP53, also widely known as p53, acts as a tumor suppressor in many tumor types, responding to diverse cellular stresses to regulate target genes that induce ...
TP63
TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many ...
TPD52
From GeneCards: TPD52 (Tumor Protein D52) is a Protein Coding gene. Diseases associated with TPD52 include Nodular Malignant Melanoma. Among its related ...
TPD52L1
tumor protein D52-like 1
TRADD
TNFRSF1A-associated via death domain
TRAF3IP2
TRAF3 interacting protein 2
TRAM1
translocation associated membrane protein 1
TRIM22
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, ...
TRIM27
tripartite motif containing 27
TRMT11
tRNA methyltransferase 11 homolog (S. cerevisiae)
TRPC3
transient receptor potential cation channel, subfamily C, member 3
TSPAN13
tetraspanin 13
TSPAN2
tetraspanin 2
TSPAN6
tetraspanin 6
TSPAN8
tetraspanin 8
TUBA1A
tubulin, alpha 1a
TUBB2B
tubulin, beta 2B class IIb
TUBB6
tubulin, beta 6 class V
UBE2D2
ubiquitin-conjugating enzyme E2D 2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
VAMP4
vesicle-associated membrane protein 4
VAMP8
vesicle-associated membrane protein 8
VWA5A
von Willebrand factor A domain containing 5A
WBP4
WW domain binding protein 4
WIPI1
WD repeat domain, phosphoinositide interacting 1
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
ZNF117
zinc finger protein 117
ZNF219
zinc finger protein 219
ZNF263
zinc finger protein 263
ZNF292
zinc finger protein 292
Projects/Protocols

Projects

Biomarkers for Early Detection of Clinically Relvant Prostate Cancer: A Multi-Institutional Validation Trial - Genomic Health, Inc.

PI: Lin UW, Daniel W.

Validate a panel of tissue-based biomarkers to determine the presence of or progression to clinically relevant prostate cancer at the time of diagnosis. ...

Glycoprotein Biomarkers for the Early Detection of Aggressive Prostate Cancer

PI: Zhang, Hui L.

The Early Detection Research Network of the NCI is charged with the discovery, development and validation of biomarkers for early detection and prognosis ...

MSA Bladder Reference Set Application: Charles Rosser-Hawaii (2014)

PI: Rosser, Charles J

The goal of this proposal is straightforward. We wish to assay in a discovery set, reference set from EDRN, both PAI-1 and ANG promoters and genes for ...

PASS Reference Set Application: Carroll Univ. of California SF (2012) PC101769 Predicting Prostate Cancer Progression at Time of Diagnosis

PI: Carroll, Peter R.

PASS Reference Set Application: Lin Univ. of Washington/OPKO (2015)

PI: Lin UW, Daniel W.

PASS Reference Set Application: Lin Univ. of Washington/OncoChip (2013)

PI: Lin UW, Daniel W.

PASS Reference Set Application: Nelson Fred Hutchinson Cancer Research Center (2013) Telomere Length in men with Prostate Cancer under Active Surveillance

PI: Nelson, Peter S

PASS Reference Set Application: Ruth Etzioni-William Beaumont Hospital (2014)

PI: Etzioni, Ruth

PCA3 Reference Set Application: Samantha Maragh NIST

PI: Maragh, Samantha

This requested sample cohort is intended to evaluate the potential for two mitochondrial DNA (mtDNA) biomarkers to be used for non-invasive early detection of ...

Prostate Rapid Pre-Validation Set

PI: Sanda, Martin

Determine which markers move to validation using the prospectie prostate reference set samples.

Prostate Rapid Reference Set Application: Daniel Chan/Patty Beckman- JHU/University of Minnesota (2007)

PI: Chan, Daniel

see publication

Prostate Rapid Reference Set Application: Robert Getzenberg - John Hopkins (2006)

Analyze marker EPCA2 on 123 observations (60 prostate cancers and 63 non-prostate cancers)

Prostate Upgrading Team Project

PI: Leach, Robin J

Aim 1: We will develop a risk assessment tool using commonly-collected clinical information from a series of contemporary radical prostatectomies to predict ...

Standard Specimen Reference Set: Prostate

PI: Sanda, Martin

To collect biologic samples on men prior to prostate biopsy, in association with clinical information and common data elements appropriate for evaluation of ...

Protocols

A Methylation Panel for Bladder Cancer

PI: Gazdar, Adi

Participate in a prevalidation study for methylation based detection of bladder cancer. In addition, a panel of three markers identified will be evaluated for ...

Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer - Supplemental Pre-Validation Protocol

PI: Czerniak, Bogdan

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Discovery for Renal Cell Carcinoma Through Serum, Urine and Tissue Protein Profiles

PI: Basler, Joseph W.

Biomarkers for Prostate and Bladder Cancer

PI: Liu, Alvin Y.

CD26+ cancer cells and CD90+ tumor-associated stromal cells were sorted from tumor tissue. Dataset analysis with transcriptomes of CD26+ luminal, CD104+ basal, ...

Body Fluids as a Source of Diagnostic Biomarkers

PI: Semmes, John

Body Fluids as a Source of Diagnostic Biomarkers: Prostate

PI: Semmes, John

Recent advances in high-throughput protein expression profiling of bodily fluids has generated great enthusiasm and hope for this approach as a potent ...

Canary TMA

PI: Nelson, Peter S

This protocol describes a multi-center, retrospective, case-cohort tissue microarray (TMA) study to evaluate tissue biomarkers for their ability to predict ...

Chemokine Prostate Cancer Biomarkers

PI: Macoska, Jill

STUDY DESIGN 1. The need for pre-validation studies. Preliminary data from our laboratory demonstrates a potential utility for CXCL5 and CXCL12 as biomarkers ...

Clinical Utility of Urinary CD90 as a Biomarker for Prostate Cancer Detection

PI: Liu, Alvin Y.

Tumor-associated stromal cells differ from normal gland-associated stromal cells in gene expression. Genes up-regulated in these stromal cells are potential ...

Detection of Bladder CA by Microsatellite Analysis (MSA)

PI: Schoenberg, Mark P.

Goal 1: To determine sensitivity and specificity of microsatellite analysis (MSA) of urine sediment, using a panel of 15 microsatellite markers, in detecting ...

Development and Clinical Validation of Biomarkers for Prostate Cancer

PI: Partin, Alan W

Development and Evaluation of a Tumor Marker for Prostate Cancer

PI: Partin, Alan W

Major strides in the early detection, staging, monitoring, and risk stratification of men with prostate cancer have been realized over the last few decades. ...

EDRN Pre-Validation of Metabolic Biomarkers of Prostate Cancer: Follow up EDRN Challenge

PI: Chinnaiyan, Arul M.

The goal of this EDRN set-asides proposal is to carry out pre-validation studies on sarcosine as a metabolomic biomarker of prostate cancer in urine. Not only ...

EDRN Pre-Validation of Multiplex Biomarker in Urine

PI: Chinnaiyan, Arul M.

The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in ...

Early Detection of Cancer by Affinity Mass Spectrometry-Set Aside funds

PI: Semmes, John

A.   RATIONALE The recent introduction of multiple reaction monitoring capabilities offers unprecedented capability to the research arsenal available to ...

Early Detection of Urinary Bladder Cancer

PI: Czerniak, Bogdan

Early Molecular Detection of Invasive Bladder Cancer by Urine Examination

PI: Czerniak, Bogdan

Establishment of a serum standard for use in high-throughput proteomic

PI: Semmes, John

Evaluating SelectMDx for the prediction of high-grade prostate cancer in men with low-grade prostate cancer on active surveillance in the Canary Prostate Active Surveillance Study (PASS)

PI: Lin UW, Daniel W.

The need for repeated biopsy is a major downside of active surveillance, and can lead to patients opting for definitive treatment or, conversely, declining to ...

GSTP1 Methylation

PI: Sidransky, David

Identification of protein and genetic biomarkers of prostate cancer and risk factors for progression of disease

PI: Leach, Robin J

Purpose/Objectives To collect biological samples from subjects with prostate cancer to improve the accuracy of screening tests, identify markers that will ...

Inflammation as a Potential Marker of Risk ad Progression for Prostate Cancer

PI: Leach, Robin J

Integrated Development of Novel Molecular Markers

PI: Sidransky, David

Methylation & Proteomics-Based Detection of Bladder Cancer

PI: Cairns, Paul

Study never Launched

Molecular Genetics of Urinary Bladder Carcinoma

PI: Czerniak, Bogdan

Molecular Progression of Methylation in Bladder Cancer

PI: Sidransky, David

Ornithine decarboxylase (ODC) Polymorphism and Breast and Prostate Cancer

PI: Helzlsouer, Kathy

PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS

PI: Lin UW, Daniel W.

Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive ...

PASS Reference Set Application: Thompson UT Health Science Center San Antonio (2014) SNPs for PCa Outcome

PI: Leach, Robin J

PCA3 Reference Set Application: T2-Erg-Martin Sanda-Emory (2014)

PI: Sanda, Martin

We hypothesize that combining T2:erg (T2:erg) fusion and PCA3 detection in urine collected after digital rectal exam can improve the specificity of identifying ...

PCA3 Validation Study and Urinary Reference Set

PI: Wei, John

Independent of serum PSA level, PCA3 score will refine the risk of having cancer detected on an extended template prostate biopsy.

Pre-Validation of Metabolomic Biomarkers of Prostate Cancer

PI: Chinnaiyan, Arul M.

Prostate Active Surveillance Study

PI: Lin UW, Daniel W.

Primary Objective: To discover and confirm biomarkers that predict aggressive disease as defined by pre-specified histological, PSA, clinical criteria, or ...

Prostate Rapid Reference Set Application: Brian Haab - Van Andel (2006)

PI: Haab, Brian

To evaluate TSP-1 as a marker to specifically detect prostate cancer

Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Prostate Reference Set Application: William Isaacs-John Hopkins (2010)

PI: Isaacs, William

Can SNP genotyping assist in the prediction of biopsy results for prostate cancer.

Prostate Reference Set Application: proPSA-Dan Chan-JHU (2008)

PI: Chan, Daniel

see Publication

Prostate-MRI

PI: Wei, John

TBD

Prostate-Specific Glycoproteins for Early Detection of Prostate Cancer

PI: Zhang, Hui L.

Release of Set Aside Funds - microRNA Biomarkers for Renal Cell Carcinoma

PI: Leach, Robin J

SELDI Phase I: Assay Validation-Prostate

PI: Semmes, John

It is then the goal of this collaborative project – EDRN-Prostate-SELDI Investigational Collaboration (EPSIC) - to use state-of-the-art protein profiling ...

SELDI Profiling of serum and urine from patients with urologic disease in support of bladder cancer studies

PI: Semmes, John

SELDI Validation Study Phase II

PI: Semmes, John

This project –A Comprehensive Program for the Validation of Prostate Cancer Early Detection with Novel Protein Identification Techniques -- is divided into ...

San Antonio Center of Biomarkers of Risk for Prostate Cancer (SABOR)

PI: Leach, Robin J

To determine if there are ways to predict which men will get prostate cancer, if there are ways to predict how a prostate cancer will develop (for example, ...

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

The Prostate Tumor Microenvironment Exhibits differentially expressed Genes Useful for Diagnosis

PI: Mercola, Dan

To develop a multi-site prospective clinical validation trial of the multigene diagnostic signature for the diagnosis of prostate cancer from non tumor ...

Upgrading Reference Set

PI: Leach, Robin J

We are proposing a multi-institutional study to identify molecular biomarkers and clinical measures that will predict presence of Gleason 7 or higher cancer ...

Using MALDI-IMS and MRM to stablish a pipeline for discovery and validation of tumor neovasculature biomarker candidates.

PI: Gambhir, Sanjiv

In an effort to circumvent the limitations associated with biomarker discovery workflows involving cell lines and cell cultures, histology-directed MALDI ...

Data
Biomarkers for Prostate and Bladder Cancer
Clinical Utility of Urinary CD90 as a Biomarker for Prostate Cancer Detection
EDRN-WHI Pre-Clinical Colon Ca Specimens
GSTP1 Methylation
MALDI Dilution Data: Randolph
Prostate Rapid Reference Set Application: Brian Haab - Van Andel (2006)
Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)
SELDI Phase I: Assay Validation-Prostate
SELDI Validation Study Phase II

Datasets Outside of any Protocol

Calendar

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Past Events

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Documents
 Title   Author   Type   Modified