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Upcoming Events

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Projects

Projects undertaken by the Lung and Upper Aerodigestive Cancers Research Group.

This collaborative group doesn't have any projects.

Biomarkers
GDNF
The GDNF gene encodes a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons. This protein is a mature ...
PMS2P7
PMS2P7, previously known as PMS2L15, was thought to be part of a multigene family found on chromosome bands 7p22, 7p12-p13, 7q11, and 7q22. These genes have ...
Zhong TAA signature
The TAA signature is a diagnostic array of five markers capable of distinguishing patients with non-small cell lung cancer (NSCLC) from normal ...
Projects/Protocols

Projects

There are currently no projects of which this group is a part.

Protocols

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer

PI: Tainsky, Michael A.

Our long term goal is to improve survival of patients with head and neck squamous cell carcinoma (HNSCC) through early detection using simple noninvasive serum ...

Biomarker Dev Lab At Moffitt Supplement

PI: Tockman, Melvyn S.

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non- progressing cancers

PI: Rom, William

We hypothesize that our novel Biomarker Panel of Auto-antibodies can distinguish aggressive, symptom diagnosed lung cancer from non-aggressive, screen-detected ...

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Collaborative study on SELDI biomarker discovery and serum protein profiling of lung cancers

PI: Semmes, John

Development of reference samples and interlaboratory testing to improve the confidence in the measurement of microRNAs

PI: Plant, Anne

Provide measurement assurance for miRNA profiling studies

Dubinett - Targeted Sequencing 2012

PI: Dubinett, Steve

we propose to use targeted massively parallel DNA sequencing to identify somatic alterations within mutational hotspots in matched sets of primary lung tumors, ...

Ecogenetic Study of Lung Cancer

PI: Spitz, Margaret R.

Identification of biomarkers for lung cancer in never smokers

PI: Gazdar, Adi

The overall goal of this project is to identify, verify and apply biomarkers for the early diagnosis or risk assessment of lung cancer in never smokers. The ...

Integrated Development of Novel Molecular Markers

PI: Sidransky, David

Lung Reference Set A Application: Edward Hirschowitz - University of Kentucky (2009)

PI: Hirschowitz, Edward

We are continuing validation with two advanced objectives: 1) To evaluate assay performance for established lung cancer diagnosed in a clinical population 2) ...

Lung Reference Set A Application: Dawn Coverley- University of York (2011)

PI: Coverley, Dawn

A variant of the nuclear matrix factor Ciz1 is prevalent in lung cancer cell lines and tumours, but not in adjacent lung tissue, giving rise to a protein that ...

Lung Reference Set A Application: LaszloTakacs - Biosystems (2010)

We would like to access the NCI lung cancer Combined Pre-Validation Reference Set A in order to further validate a lung cancer diagnostic test candidate. Our ...

Lung Reference Set A Application: Lee Goodglick/ Eleftherios Diamandis- UCLA/MSH (2009)

PI: Chia, David

To study of the utility of KLK8, 11, 12, 13, and 14 profiles in diagnosing lung cancer.

Lung Reference Set A Application: Pierre Massion-Vanderbilt (2017)

PI: Massion, Pierre

Lung Reference Set C Application: Rachel Ostroff - SomaLogics (2010)

PI: Ostroff, Rachel

Analysis of the EDRN lung biomarker samples will enable the next step in development of a clinical diagnostic assay for the differential diagnosis of lung ...

NYU Lung Cancer Biomarker Center

PI: Rom, William

A. SPECIFIC AIMS 1. To develop and prospectively follow a large cohort at high-risk for lung cancer. Individuals are recruited to one of two different ...

Nashville Early Diagnosis Lung Cancer Project

PI: Massion, Pierre

New Biomarkers & Dysplastic Respiratory Epithelium

Proteomic Approach for Diagnostic Applications in Head and Neck Cancer

PI: Tainsky, Michael A.

To evaluate the test characteristics of a panel of biomarkers for identifying patients with early stage head and neck squamous cell carcinoma (HNSCC). The ...

Protocol for Comparing Promoter Hypermethylation Methods in NSCLC

PI: Tockman, Melvyn S.

Soluble Mesothelin Related Peptide (SMRP) and Osteopontin (OPN) as Early Detection Markers for Malignant Mesothelioma (MM)

PI: Pass, Harvey Ira

Phase I: - Identification and assemblage of representative cohorts of individuals with MM, no malignancies but increased risk for MM due to asbestos exposure, ...

Standard Specimen Reference Set: Lung

PI: Bigbee, William L.

The NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) began its activities back in November 2004 and developed clear objectives and strategies on how to begin ...

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

US-Turkey Cappadocia Mesothelioma Project

PI: Pass, Harvey Ira

Study never launched.

Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population

PI: Pass, Harvey Ira

A prospective study to evaluate the utility of various biomarkers in the context of an MM Early Detection Program. The study cohort will be composed of workers ...

Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)

PI: Spira, Avrum

To characterize intra or within subject reproducibility and variability To characterize inter or across subject variability by adenoma phenotype (normal vs. ...

Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques

PI: Hanash, Samir

1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ...

Validation of the Mutagen Sensitivity and Chromosomal Hotspot Assays

PI: Spitz, Margaret R.

Data
Development of reference samples and interlaboratory testing to improve the confidence in the measurement of microRNAs
Identification of biomarkers for lung cancer in never smokers
Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques
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Documents
 Title   Author   Type   Modified