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Biomarkers
5p15
Locus 5p15 has been identified as a region of lung cancer susceptibility through genome-wide association studies.
7p12 (EGFR)
Chromosome region 7p12 contains the EGFR gene. Copy number gains in this chromosome region have been implicated in lung cancer.
80 Gene Panel for Lung Cancer
This 80-gene biomarker panel is used to distinguish smokers with lung cancer from smokers without lung cancer. The biomarker panel had approximately 90% ...
8q24 (C-MYC)
Chromosome region 8q24 contains the gene for MYC, also known as C-MYC. MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle ...
ACBP
DBI, diazepam binding inhibitor, was previously known as ACBP, acyl-coA binding protein. This protein is regulated by hormones, is involved in lipid ...
AIM
AIM1 may function as suppressor of malignant melanoma. It is also thought to exert its effects through interactions with the cytoskeleton.
AKR1B10
The AKR1B10 protein is a member of the aldo/keto reductase superfamily. This superfamily has more than 40 known enzymes and proteins. AKR1B10 acts as an ...
ALDH3A1
ALDH3A1 is a member of the aldehyde dehydrogenase family. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and ...
ANG
Angiogenin, or ANG, is a mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to ...
ANGPTL3
ANGPTL3, or angiopoietin-like 3, is a member of the angiopoietin-like family of secreted factors. It is a secreted protein expressed primarily in the liver, ...
Annexin 1 and SOX2
ANXA1
Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. ...
ANXA2
ANXA2, a member of the annexin family, is a calcium-dependent phospholipid-binding protein that plays a role in the regulation of cellular growth and in signal ...
APC
The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell ...
APEX1
APEX1 is the major endonuclease in human cells, playing a role in DNA repair and the celluar response to oxidative stress. APEX1 is an apurinic/apyrimidinic ...
BAC clone RP11-499F19
BAC clone RP11-499F19 is available in Genbank as accession number AC108477. There is no associated protein sequence and no known protein function.
Bajtarevic VOCs signature
Exhaled breath was collected and differences in concentration for more than 50 volatile organic compounds (VOCs) was assayed by various methods.
Bianchi 34-marker miRNA Signature for Lung Cancer
This signature was developed based on the detection of 34 microRNAs (miRNAs) from serum that could identify patients with early stage non-small cell lung ...
BMP1
Boeri miRNA signature of diagnosis of lung cancer
miRNA expression analyses in plasma samples collected 1-2 years before the onset of disease, at the time of CT detection and in disease-free smokers ...
Boeri miRNA signature of risk for lung cancer
miRNA expression analyses in plasma samples collected 1-2 years before the onset of disease, at the time of CT detection and in disease-free ...
BPIFA1
The BPIFA1 gene was formerly known as PLUNC. This human gene is the homolog of murine Plunc, and shows the same expression pattern as murine Plunc. Both are ...
BVES
The BVES gene encodes a protein that is a member of the POP family and is thought to contain three transmembrane domains. The protein is a cell adhesion ...
C1S
C9
CA15-3
From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role ...
CAGE
Promoter hypermethylation of the CAGE1 gene is related to plays a crucial role during the phenotypical morphogenesis of several types of cancer. CAGE1 shows ...
CAPN1
CAPNS1
CAT
The CAT gene product, catalase, occurs in the peroxisome of almost all respiring organisms. Catalase is a heme enzyme that converts the reactive oxygen species ...
CBLC
CBLC is a nuclear protein which interacts with a restricted range of of SH3 domain proteins and regulates EGFR mediated signal transduction. CBLC is ...
CCL15
CCL18
CCL18, also known as MIP-4, is a member of the cytokine family, a family of secreted proteins involved in immunoregulatory and inflammatory processes. ...
CDH1
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein ...
CDH13
CDH13 is a member of the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular ...
CDK5
CDK5R1
CEACAM5
From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the ...
CEBPG
The CEBPG protein is a transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene.. The C/EBP family of ...
CEP3
CEP3 is the designation for the centromere region of chromosome 3. Amplification of this region has been identified in lung cancer.
CEP6
CEP6 is the designation for the centromere region of chromosome 6. Amplification of this region has been linked to presence or development of lung cancer.
Chen 10-marker miRNA signature for non-small cell lung cancer
A panel of 10 serum miRNAs has been identified that were found to have significantly different expression levels in non-small cell lung cancer (NSCLC) ...
CKB
CKM
CKM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. It reversibly catalyzes the transfer of ...
CNTN5
CSTA
CSTA, or cystatin-A, is a member of the cystatin superfamily, which includes proteins that contain multiple cystatin-like sequences. Some members of the ...
CXCL13
CXCL8
CXCL8, commonly known as IL8, is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that ...
CYFRA 21-1
CYFRA 21-1 is a test measuring a cytokeratin-19 fragment that is soluble in human serum and may be a useful circulating tumor marker. The test was developed ...
CYGB
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other ...
CYP24A1
The CYP24A1 protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions ...
Cytochrome C
CYCS, or cytochrome C, is an electron carrier protein that is an important part of the electron transport chain in mitochondria. The cytochrome C protein is a ...
DAP
DAP, or death-associated protein, is a basic, proline-rich, 15-kD protein. It acts as a positive mediator of programmed cell death that is induced by ...
DAPK1
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD ...
DCC
DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell ...
Des-ubiquitin
Des-ubiquitin is formed when a cysteine protease cleaves two carboxy-terminal glycine residues from ubiquitin.
E2F1
The E2F1 protein belongs to the E2F/DP family of transcription factors. E2F1 binds DNA cooperatively with dp (differentiation regulated transcription factor ...
EEF1A1
From NCBI Entrez Gene: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of ...
EFEMP1
EFEMP1, also known as fibulin-3, binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. It ...
EGFR
From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor ...
endostatin
COL18A1, also known as endostatin, is the alpha chain of type XVIII collagen. COL18A1 is one of the multiplexins, extracellular matrix proteins that contain ...
ENO2
ERBB2
From NCBI Gene: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand ...
ERCC4
ERCC4 is a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. It forms a complex with ERCC1 and is involved in ...
ERCC5
The ERCC5 gene encodes a single-stranded structure-specific DNA endonuclease involved in DNA excision repair following UV-induced damage. ERCC5 makes the ...
EXOC6B
From NCBI Entrez Gene: In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis.[supplied by OMIM, Apr 2004]
Farlow 6-marker panel for Lung Cancer
This study aimed to develop a serum test that could be used to discern NSCLC patients from cancer-free controls and may provide a means to indicate who ...
FGF17
FGF2
From NCBI Gene: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad ...
FHIT
FHIT, or fragile histidine triad, is a member of the histidine triad gene family. The FHIT protein is a diadenosine ...
FYN
GAGE7
GAGE7 is a member of a family of genes that code for an antigenic peptide, YRPRPRRY. These genes are thought to be expressed in a variety of tumors but ...
GBU4-5
GBU-4 is a recently identified protein which was identified using SEREX technologies. GBU4-5 has a DEAD-box domain (like the CAGE protein), but until 2003 had ...
GDNF
The GDNF gene encodes a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons. This protein is a mature ...
GPX1
The GPX1 gene product, glutathione peroxidase 1, is a member of the glutathione peroxidase family. Family members are involved in the detoxification of ...
GPX3
The GPX3 gene product, glutathione peroxidase 3, is a member of the glutathione peroxidase family. Family members are involved in the detoxification of ...
GSTM3
The GSTM3 gene product is glutathione S-transferase mu 3. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene ...
GSTP1
Glutathione S-transferases are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and ...
GSTT1
The GSTT1 gene encodes glutathione S-transferase theta 1, a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a ...
GSTZ1
The GSTZ1 gene product, glutathione transferase zeta 1, is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes ...
Halling 4-marker LAVysion lung cancer probe set
This panel is comprised of the commercially available LAVysion probe set, Abbott Molecular, Des Plaines, IL. This panel was used by Halling, et al, to compare ...
Hanash 3 marker panel for Lung Cancer
The EDRN validation study ("Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques") presents evidence for the occurrence in ...
HAPLN1
This widely expressed protein stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
HE4
11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of ...
HFE2
HFE2, also known as RGM-C, is a member of the repulsive guidance molecule (RGM) family and is involved in iron metabolism. HFE2 may act as a bone ...
HSP70-9B
HSP70-9B (HSPA9) is a member of the heat shock protein 70 family. The protein is found mostly in the mitochondria, but is also seen in endoplasmic reticulum, ...
HSP90a
The HSP90AA1 protein, also known as HSP90a, is a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific ...
HSP90AB1
HYAL2
HYAL2, or hyaluronoglucosaminidase 2, is a weak acid-active hyaluronidase. HYAL2 breaks down hyaluronan, one of the major glycosaminoglycans of the ...
IL15RA
IL17B
IMPDH2
The enzyme IMPDH2 catalyzes the rate-limiting step of conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed ...
KCNH5
KCNH5 is a member of the potassium channel, voltage-gated, subfamily H family of voltage-gated potassium channels. The voltage-gated potassium channels are a ...
KIT
SCF-sR, also known as KIT, is the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma ...
KLK7
KPNB1
LDHB
LGMN
LMR1
LOC147166
LRIG3
The LRIG3 protein is a widely expressed type I membrane protein. It contains three Ig-like C2-type (immunoglobulin-like) domains, 15 LRR (leucine-rich) ...
MALAT1
MALAT1 is a non-protein coding RNA known to be associated with lung adenocarcinoma.
MAPK13
Massion 4-marker FISH panel for lung cancer
The combination of these 4 probes, TP63, MYC, CEP3, and CEP6, offered a sensitivity of 82% for lung cancer and a specificity of 58%. These results indicate ...
Massion CEP6 + sputum cytology + demographics
CEP6 is the designation for the centromere region of chromosome 6. Amplification of this region has been identified in lung cancer.
MDK
METAP2
MGMT
MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. It repairs alkylated guanine in DNA by ...
MGST1
MGST1, or microsomal glutathione S-transferase 1, is a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid ...
MIF
MIF, a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation, plays a role in the regulation of macrophage function in host defense ...
MIR126
From NCBI Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in ...
MIR200B
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by ...
MIR21
From NCBI Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in ...
MIR210
From NCBI Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in ...
MIR375
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by ...
MIR486
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by ...
MIR486-5p
From NCBI Gene: MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in ...
MMP9
MMP9 is a member of the matrix metalloproteinase (MMP) family. It is a secreted protein that may play an essential role in local proteolysis of the ...
MPG
MPG is a DNA repair enzyme that repairs hypoxanthine, which is formed by spontaneous or oxidative deamination of adenine. MPG also repairs secondary oxidative ...
MRC1
MTHFR
The MTHFR gene product catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to ...
MYC
The oncogenic protein MYC, previously known as c-MYC, is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and ...
NACA
NAGK
NY-ESO-1
NY-ESO-1, official name CTAG1B, is an antigen that is expressed in normal testis and ovary and overexpressed in a wide variety of cancers. The CTAG1B ...
OGG1
8-Oxoguanine DNA Glycosylase, or OGG1, is a DNA repair enzyme that removes both 7,8-dihydro-8-oxoguanine and ...
OLFM1
From NCBI Entrez Gene: This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact ...
OPCML
The OPCML protein is a member of the IgLON subfamily in the immunoglobulin protein superfamily. OPCML binds opioids in the presence of acidic lipids. The ...
p16
The CDKN2A locus generates several transcript variants which differ in their first exons. Two distinct transcripts are produced from different promoters: p16 ...
PARK7
DJ-1, also known as PARK-7, belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It ...
PAX8
The PAX8 gene product is a member of the paired box (PAX) family of transcription factors. It is a transcription factor for the thyroid-specific expression of ...
Pecot MALDI MS signature + clinical and imaging data
A serum proteomic signature of seven features identified by MALDI MS was previously identified (see "Yildiz MALDI MS signature for lung cancer"). The serum ...
pentraxin-3
PGAM1
PGAM1 catalyzes the interconversion of 3- phosphoglycerate (3-PGA) and 2-phosphoglycerate (2-PGA) in the glycolytic pathway, with 2,3-bisphosphoglycerate as ...
Philips VOCs signature
A combination of 22 breath volatile organic compounds (VOCs), predominantly alkanes, alkane derivatives, and benzene derivatives, that can discriminate between ...
PITX2
The PITX2 protein is a member of the RIEG/PITX paired homeobox family, in the bicoid class of homeodomain proteins. PITX2 acts as a transcription factor, ...
pleiotrophin
Pleiotrophin, or PTN, is a secreted growth factor found in osteoblasts and brain tissue. PTN induces neurite outgrowth and is mitogenic for fibroblasts, ...
PMS2P7
PMS2P7, previously known as PMS2L15, was thought to be part of a multigene family found on chromosome bands 7p22, 7p12-p13, 7q11, and 7q22. These genes have ...
PRKCI
PRKCI is a member of the protein kinase C (PKC) family of serine/threonine protein kinases. It is a calcium- and diacylglycerol-independent ...
Proteomic Panel for Lung Cancer
An immunoaffinity-mass spectrometry-based quantification approach was used to develop an assay for verifying the expression of potential biomarkers in patient ...
PTPRN2
PTPRN2 is a member of the protein tyrosine phosphatase (PTP) family. These proteins are signaling molecules that regulate a variety of cellular processes ...
PVRL4
The PVRL4 protein, also known as nectin-4, is a member of the nectin family. PVRL4 contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like ...
PXN
From NCBI Entrez Gene: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix ...
Rahman 9-marker MALDI MS panel for Lung Cancer
This panel was derived from the proteomic analysis of bronchial lesions that could predict the diagnosis of lung cancer. Nine matrix-assisted laser desorption ...
RARB
The RARB gene encodes the retinoic acid receptor beta. It is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional ...
RASSF1
RASSF1A is a potential tumor suppressor. It is required for death receptor-dependent apoptosis and mediates activation of STK4 during Fas-induced apoptosis. ...
RBP4
The RBP4 protein is a member of the lipcalin family. RBP4 delivers retinol (vitamin A alcohol) from the liver stores to the peripheral tissues via the blood. ...
REN
RPS27A
Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different ...
RPSA
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide ...
RUNX3
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to ...
S-Adenosylmethionine
S-adenosylmethionine, also known as AdoMet or SAMe, is a biochemical intermediate involved in methyl group transfers. S-adenosylmethionine is formed from from ...
S100P
The S100P protein is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100P is a homodimer, and it interacts with S ...
SELL
From NCBI Gene and UniProtKB/Swiss-Prot: sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing ...
SERPINA1
Alpha-1-antitrypsin is secreted and is an extracellular serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, ...
SERPINB3
Squamous cell carcinoma antigen (SCCA) may act as a protease inhibitor to modulate the host immune response against tumor cells. Present in the cytoplasm of ...
SFTPB
SFTPB, or pulmonary-associated surfactant protein B, is an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary ...
SFTPC
SFTPC, or pulmonary surfactant-associated protein C, is a hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary ...
Shen 4-marker miRNA panel for lung cancer
We initially validated expressions of a set of miRNAs in paired lung tumor tissues and plasma specimens from 28 stage I NSCLC patients by real-time ...
Showe 29-gene signature for lung cancer
A 29-gene peripheral blood gene expression signature that separates patients with non-small cell lung cancer (NSCLC) tumors and patient controls with 86% ...
SHOX2
SHOX2 is a member of the homeobox family of genes. These genes are transcriptional regulators involved in pattern formation in both invertebrate and ...
SLPI
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical ...
SMRP
Soluble mesothelin-related protein (SMRP) is related to the mesothelin family of molecules. It is overexpressed in ovarian cancer, malignant ...
SOD1
SOD1, superoxide dismutase, is one of two isozymes that destroy free superoxide radicals that are normally produced within the cells and which are toxic to ...
Somalogic 12-marker panel for lung cancer
The sensitivity and specificity of our 12-biomarker panel improves upon published protein and gene expression panels. The 12-protein panel consists ...
SOX2
From NCBI Gene: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic ...
Spira 80-marker panel plus clinical factors
This clinicogenomic model incorporates the gene expression pattern of histologcially normal large airway epithelial cells collected at time of ...
SPP1
Osteopontin, also known as SPP1 or OPN, a secreted, integrin-binding matrix phosphorylated glycoprotein is involved in bone remodeling by osteoclasts and ...
Tanaka Circulating Tumor Cells (CTCs)
Circulating tumor cells (CTC) can be found and quantitatively evaluated with a semiautomated system (CellSearch) in patients with primary lung cancer. CTC ...
TCF21
TCF21 is involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. ...
TFPI
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the ...
TIMP1
The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in ...
TMSB4X
TMSB4X, or thymosin beta-4, belongs to the thymosin beta family. It is an actin sequestering protein which plays an important role in the regulation ...
TNF
TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and ...
TNFRSF25
The TNFRSF25 gene product is a member of the TNF-receptor superfamily. TNFRSF25 protein is a receptor for TNFSF12/APO3L/TWEAK. It mediates activation of ...
TNFSF8
TNFSF8, also known as CD30 ligand, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. TNFSF8 binds to TNFRSF8/CD30, a cell surface ...
TP53
TP53, also widely known as p53, acts as a tumor suppressor in many tumor types, responding to diverse cellular stresses to regulate target genes that induce ...
TP63
TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many ...
UBA52
Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different proteins. ...
UBB
Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different ...
UBC
Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different ...
Ubiquitin
The ubiquitin protein was named due to its ubiquitous presence in the human body. This small protein, comprised of 76 amino acids, is coded for by a ...
UBQLN1
The ubiquilin gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. ...
UCHL1
PGP9.5, also called Ubiquitin-protein hydrolase (UCHL1), is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to ...
VEGFA
Vascular endothelial growth factor (VEGFA or VEGF) is a growth factor and signaling protein involved in the regulation of angiogenesis, vasculogenesis, and ...
Wu 6-marker phage peptide panel for Lung Cancer
The six-phage peptide detector stands out as a promising diagnostic biomarker for NSCLC. The peptide panel could be used to diagnose non-small cell ...
XRCC1
XRCC1, or X-ray repair complementing defective repair in Chinese hamster cells 1, corrects defective DNA strand-break repair and sister chromatid exchange ...
XRCC5
From NCBI Entrez Gene: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA ...
YES
YES1, also known as YES, is a non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell ...
Yildiz MALDI MS signature for lung cancer
A serum proteomic signature of seven features identified by MALDI MS has been identified. The serum signature was associated with the diagnosis of lung cancer ...
YWHAQ
YWHAQ, also known as 14-3-3 theta, belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. ...
Zhong 5-antibody panel for Lung Cancer
A potential autoantibody profile was developed to screen for non-small cell lung cancer. 212 immunogenic phage-expressed proteins were statistically ...
Zhong TAA signature
The TAA signature is a diagnostic array of five markers capable of distinguishing patients with non-small cell lung cancer (NSCLC) from normal ...
Projects/Protocols

Projects

There are currently no projects of which this group is a part.

Protocols

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer

PI: Tainsky, Michael A.

Our long term goal is to improve survival of patients with head and neck squamous cell carcinoma (HNSCC) through early detection using simple noninvasive serum ...

Biomarker Dev Lab At Moffitt Supplement

PI: Tockman, Melvyn S.

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non- progressing cancers

PI: Rom, William

We hypothesize that our novel Biomarker Panel of Auto-antibodies can distinguish aggressive, symptom diagnosed lung cancer from non-aggressive, screen-detected ...

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Collaborative study on SELDI biomarker discovery and serum protein profiling of lung cancers

PI: Semmes, John

Development of reference samples and interlaboratory testing to improve the confidence in the measurement of microRNAs

PI: Plant, Anne

Provide measurement assurance for miRNA profiling studies

Dubinett - Targeted Sequencing 2012

PI: Dubinett, Steve

we propose to use targeted massively parallel DNA sequencing to identify somatic alterations within mutational hotspots in matched sets of primary lung tumors, ...

Ecogenetic Study of Lung Cancer

PI: Spitz, Margaret R.

Identification of biomarkers for lung cancer in never smokers

PI: Gazdar, Adi

The overall goal of this project is to identify, verify and apply biomarkers for the early diagnosis or risk assessment of lung cancer in never smokers. The ...

Integrated Development of Novel Molecular Markers

PI: Sidransky, David

Lung Reference Set A Application: Edward Hirschowitz - University of Kentucky (2009)

PI: Hirschowitz, Edward

We are continuing validation with two advanced objectives: 1) To evaluate assay performance for established lung cancer diagnosed in a clinical population 2) ...

Lung Reference Set A Application: Dawn Coverley- University of York (2011)

PI: Coverley, Dawn

A variant of the nuclear matrix factor Ciz1 is prevalent in lung cancer cell lines and tumours, but not in adjacent lung tissue, giving rise to a protein that ...

Lung Reference Set A Application: LaszloTakacs - Biosystems (2010)

We would like to access the NCI lung cancer Combined Pre-Validation Reference Set A in order to further validate a lung cancer diagnostic test candidate. Our ...

Lung Reference Set A Application: Lee Goodglick/ Eleftherios Diamandis- UCLA/MSH (2009)

PI: Chia, David

To study of the utility of KLK8, 11, 12, 13, and 14 profiles in diagnosing lung cancer.

Lung Reference Set A Application: Pierre Massion-Vanderbilt (2017)

PI: Massion, Pierre

Lung Reference Set C Application: Rachel Ostroff - SomaLogics (2010)

PI: Ostroff, Rachel

Analysis of the EDRN lung biomarker samples will enable the next step in development of a clinical diagnostic assay for the differential diagnosis of lung ...

NYU Lung Cancer Biomarker Center

PI: Rom, William

A. SPECIFIC AIMS 1. To develop and prospectively follow a large cohort at high-risk for lung cancer. Individuals are recruited to one of two different ...

Nashville Early Diagnosis Lung Cancer Project

PI: Massion, Pierre

New Biomarkers & Dysplastic Respiratory Epithelium

Proteomic Approach for Diagnostic Applications in Head and Neck Cancer

PI: Tainsky, Michael A.

To evaluate the test characteristics of a panel of biomarkers for identifying patients with early stage head and neck squamous cell carcinoma (HNSCC). The ...

Protocol for Comparing Promoter Hypermethylation Methods in NSCLC

PI: Tockman, Melvyn S.

Soluble Mesothelin Related Peptide (SMRP) and Osteopontin (OPN) as Early Detection Markers for Malignant Mesothelioma (MM)

PI: Pass, Harvey Ira

Phase I: - Identification and assemblage of representative cohorts of individuals with MM, no malignancies but increased risk for MM due to asbestos exposure, ...

Standard Specimen Reference Set: Lung

PI: Bigbee, William L.

The NCI/EDRN/SPORE Lung Cancer Biomarkers Group (LCBG) began its activities back in November 2004 and developed clear objectives and strategies on how to begin ...

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

US-Turkey Cappadocia Mesothelioma Project

PI: Pass, Harvey Ira

Study never launched.

Utility of Biomarkers for Early Detection of Malignant Mesothelioma in a High-risk Population

PI: Pass, Harvey Ira

A prospective study to evaluate the utility of various biomarkers in the context of an MM Early Detection Program. The study cohort will be composed of workers ...

Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)

PI: Spira, Avrum

To characterize intra or within subject reproducibility and variability To characterize inter or across subject variability by adenoma phenotype (normal vs. ...

Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques

PI: Hanash, Samir

1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers ...

Validation of the Mutagen Sensitivity and Chromosomal Hotspot Assays

PI: Spitz, Margaret R.

Data

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