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Biomarkers
4DELF
Identification of preneoplastic changes in histologically normal epithelium (the "field effect") could provide a powerful screening tool for colorectal cancer. ...
8-gene Panel for Barrett's Esophagus
Eight methylation biomarkers - p16, RUNX3, HPP1 (HGNC name TMEFF2), NELL1, TAC1, SST, AKAP12 and CDH13 - were tested in a restrospective multicenter ...
Aberrant Vimentin DNA Methylation in Stool
The VIM gene encodes a member of the intermediate filament family. VIM proteins are class-III intermediate filaments found in various non-epithelial ...
AFP
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with ...
AFP-L3
AFP-L3, also known as lectin-bound AFP, is an isoform of AFP, a major plasma protein produced by the yolk sac and the liver during fetal life. ...
AFPIC
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with ...
AKAP12
AKAP12 is a member of the A-kinase anchor protein (AKAP) family, a group of structurally diverse proteins which have the common function of binding to the ...
ALCAM
CD166 is a sticky cell adhesion molecule that binds to CD6. It is involved in neurite extension by neurons via heterophilic and homophilic interactions and may ...
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker ...
CCSA-2
CCSA-2 is a potential serum-based marker for colon cancer detection with high sensitivity and specificity. Receiver operating characteristic analyses were used ...
CCSA-3
Colon cancer-specific antigen CCSA-3 is a novel colon cancer marker of colorectal cancer and advanced adenomas identified by focused proteomic analysis of ...
CCSA-4
Colon cancer-specific antigen CCSA-4 is a novel colon cancer marker of colorectal cancer and advanced adenomas identified by focused proteomic analysis of ...
CCSP-1
Expression microarrays have identified colon cancer secreted protein-1 (CCSP-1) as a novel transcript whose expression is generally absent in normal colon and ...
CCSP-2
Expression microarrays have identified colon cancer secreted protein-2 (CCSP-2) as a novel transcript whose expression is generally absent in normal colon and ...
CDH13
CDH13 is a member of the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular ...
DCP
Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal ...
galectin-3 ligand
Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin. Galectin-3 ...
GP73
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi ...
Haptoglobin-related glycoprotein
A major circulating ligand for galectin-3, which is elevated in the sera of patients with colon cancer, is a cancer-associated glycoform of haptoglobin. In ...
ICAM1
From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to ...
IGFBP4
The IGFBP4 gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin ...
KNG1
Kininogens are inhibitors of thiol proteases. The KNG1 gene uses alternative splicing to generate two different proteins- high molecular weight kininogen ...
KRAS
The KRAS gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single ...
LEBS
Low-coherence enhanced backscattering (LEBS) is a technique that has recently shown promise for tissue characterization and the detection of early pre-cancer. ...
Meltzer 3-marker panel for Esophageal Adenocarcinoma
Using real-time quantitative methylation-specific PCR, ten genes (HPP1, RUNX3, RIZ1, CRBP1, 3-OST-2, APC, TIMP3, p16, MGMT and p14) were screened for promoter ...
Meltzer 3-marker panel with clinical features for Esophageal Adenocarcinoma
Barrett's esophagus predisposes to esophageal adenocarcinoma. This biomarker is part of a three-tiered risk stratification strategy, based on ...
NELL1
NELL1 is a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth ...
p16
The CDKN2A locus generates several transcript variants which differ in their first exons. Two distinct transcripts are produced from different promoters: p16 ...
REG1A
REG1 is a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic ...
REG3A
REG3 is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The ...
RUNX3
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to ...
SCCAIC
SCCAIC, squamous cellular carcinoma antigen (SCCA) immunocomplexed with IgM, has been proposed as an alternative marker. Squamous cell carcinoma antigen (SCCA) ...
SERPINA1
Alpha-1-antitrypsin is secreted and is an extracellular serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, ...
SERPINB3
Squamous cell carcinoma antigen (SCCA) may act as a protease inhibitor to modulate the host immune response against tumor cells. Present in the cytoplasm of ...
SST
The hormone somatostatin (SST) has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. ...
TAC1
The tachykinin gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide ...
TIMP1
The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in ...
TMEFF2
HPP1 (also called TMEFF2) may be a survival factor for hippocampal and mesencephalic neurons. The shedded form (generated by proteolytic shedding) up-regulates ...
TNFRSF6B
DcR3 belongs to the tumor necrosis factor receptor superfamily and is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. ...
Projects/Protocols

Projects

Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)

PI: Schoen, Robert E.

The goal of this project is to evaluate biomarkers in normal colonic mucosa to determine their relationship to the occurrence of short- and long-term ...

Pancreatic Cystic Fluid Reference Set

PI: Brand, Randall E.

The proposed reference set will be designed to evaluate biomarkers for the following applications aimed at determining whether a patient would benefit from ...

Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)

PI: Brenner, Dean

the goal of identifying those biomarkers developed by the GI collaborative that will predict the presence of advanced colorectal adenomas.

Protocols

Affinity-based strategies to fast track development of colon cancer biomarkers

PI: Lampe, Paul

Our goal is to discover plasma and tissue-based tumor biomarkers that work well enough together to identity colon cancer at early stages, lead to accurate ...

Barrett's Esophagus Methylation Profiles

PI: Meltzer, Stephen

We propose a nested case-control study of biomarkers in the setting of BE. By bringing together research institutions with large populations of patients with ...

Biomarkers for early detection of pancreatic cancer

PI: Lokshin, Anna

Background: The clinical management of pancreatic cancer is severely hampered by the absence of effective screening tools. Methods: Sixty-seven biomarkers ...

Biomarkers for the Early Detection of Pancreatic Cancer

PI: Killary, Ann M.

Clinical and Analytical Validation of Cancer Biomarkers: Developmental Studies

PI: Chan, Daniel

Colon Reference Set Application: Robert Getzenberg - Johns Hopkins (2008)

The goal of this project is to confirm the early validation of CCSA-3 and CCSA-4 as biomarkers for the early detection of adenocarcinoma of the colon and ...

Colon Reference Set Application: Mary Disis - University of Washington (2008)

PI: Disis, Mary L

The proposed study aims to validate the diagnostic value of a panel of serum antibodies for the early detection of colorectal cancer (CRC). We have developed a ...

Colon Reference Set Application: Moncef Jendoubi - Milagen (2006)

PI: Jendoubi, Moncef

Confidential

Colon Reference Set Application: Nam Kim - DiaDexus (2008)

PI: Kim, Nam

The EDRN Colorectal reference samples will be useful in confirming the potential application of novel serum markers for colorectal cancer that can detect ...

Detection of cancer DNA markers in urine

PI: Block, Timothy

Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers

PI: Gambhir, Sanjiv

Our goal is to develop a blood-based biomarker magneto-nanosensor array for the accurate early detection and prognostication of prostate cancer

EDRN-WHI Pre-Clinical Colon Ca Specimens

PI: Hanash, Samir

Specifically, it is proposed to assess plasma proteins from postmenopausal women diagnosed with colon cancer within a span of 18 months after year-3 OS blood ...

Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies

PI: Hollingsworth, Michael

Determining and quantifying the types of mucin core proteins to which CA19-9 is attached will result in assays with improved performance characteristics ...

Early detection of liver cancer and hepatitis

PI: Block, Timothy

GLNE 003: Preliminary Validation of Biomarkers Predictive of Barrett’s Esophagus Progression to Dysplasia and Adenocarcinoma

PI: Brenner, Dean

   Recognizing that novel potential biomarkers are continually being identified and will need to be validated in a rapid, efficient, and scientifically ...

HNPCC colon cancer-associated SELDI mass spectrometry protein profiles in serum

PI: Lynch, Henry

Hepatocellular carcinoma Early Detection Strategy study

PI: Marrero, Jorge

Part 1: The first part of this study is to conduct follow-up for patients that were enrolled in the EDRN Phase 2 Validation Study called DCP (13). For this ...

Hereditary Cancer Institute family study specimen bank

PI: Lynch, Henry

Hollingsworth - Aggressive vs Indolent 2012

PI: Hollingsworth, Michael

Study Overview. We will examine DNA extracted from FFPE sections from approximately 200 different surgically resected primary pancreatic tumors from the UNMC ...

Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia

PI: Lynch, Henry

Liver Full Reference Set Application :Timothy Block - Drexel Univ (2010)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

Liver Full Reference Set Application: David Lubman - Univ of Michigan (2011)

PI: Lubman, David

In this work we will perform the next step in the biomarker development and validation. This step will be the Phase 2 validation of glycoproteins that have ...

Liver Full Reference Set Application: Hiro Yamada - Wako (2011)

PI: Yamada, Hiro

Wako has received new 510(k) clearance for Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) and Des-gamma-carboxy prothrombin (DCP) ...

Liver Rapid Reference Set Application ( #2): Lubman - Univ of Michigan (2010)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Rapid Reference Set Application (#1): David Lubman - Univ of Michigan (2009)

PI: Lubman, David

We are requesting the reference set, which includes 50 HCC cases and 50 cirrhotic controls. In our preliminary study, AFP had a AUROC of 0.66 while the AUROC ...

Liver Rapid Reference Set Application (#1): Laura Beretta-FHCRC (2011)

PI: Beretta, Laura

Test 2 candidate biomarkers for early detection of HCC. Marker S and Marker L.

Liver Rapid Reference Set Application (#2): Laura Beretta-FHCRC (2011)

PI: Beretta, Laura

Test 2 candidate biomarkers for early detection of HCC. Marker S and Marker L.

Liver Rapid Reference Set Application: Gary Norman-INOVA (2012)

PI: Norman, Gary L.

We have developed a new and novel assay for the detection of Golgi protein 73 (GP73), also known as Golgi membrane protein 1 (Golm1) or Golgi phosphoprotein 2 ...

Liver Rapid Reference Set Application: Gianluigi Giannelli - Univ of Bari (2008)

PI: Giannelli, Gianluigi

To evaluate biomarker performance in an out-side cohort of LC and HCC patients

Liver Rapid Reference Set Application: Hemken - Abbott (2015)

PI: Hemken, Philip M

The aim for this testing is to find a small panel of biomarkers (n=2-5) that can be tested on the Abbott ARCHITECT automated immunoassay platform for the early ...

Liver Rapid Reference Set Application: Hiro Yamada - Wako (2011)

PI: Yamada, Hiro

Measure clinical effectiveness of AFP-L3 and DCP for early detection of HCC in patient samples collected prospectively during surveillance. However since such ...

Liver Rapid Reference Set Application: Kevin Qu-Quest (2011)

PI: Qu, Kevin

We propose to evaluate the performance of a novel serum biomarker panel for early detection of hepatocellular carcinoma (HCC). This panel is based on markers ...

Liver Rapid Reference Set Application: Timothy Block - Drexel Univ (2008)

PI: Block, Timothy

The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular ...

MMR protein expression in HNPCC

PI: Lynch, Henry

Methylation tumor markers in HNPCC

PI: Lynch, Henry

Molecular Basis of Barrett's -Associated Carcinogenesis

PI: Stass, Sanford

Mutational load distribution analysis (MLDA) in pancreatic cancer

PI: Lynch, Henry

Certain p16 mutation carriers showed mutation elevations in the specific Ki-ras and p53 alleles significantly higher than normal, similar to controls with ...

Novel Surveillance Strategies For Hereditary Nonpolyposis Colon Cancer Family Members

PI: Lynch, Henry

Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside)

PI: Lokshin, Anna

Pancreatic Reference Set Application- Ann Killary-MD Anderson (2012)

PI: Killary, Ann M.

ELISA assays. We propose to screen a two gene panel (TNC/TFPI) from functional genomic pathways approaches, by ELISA assays, in a collection of blinded plasma ...

Pancreatic Reference Set Application: Brian Haab-Van Andel (2012)

PI: Haab, Brian

New markers are greatly needed for the detection and diagnosis of pancreatic cancer. Patients at high risk for developing pancreatic cancer (for, example ...

Pancreatic Reference Set Application: Ivan Blasutig-University of Toronto (2014)

PI: Blasutig, Ivan

The primary objective of this study is to independently validate a panel of serum biomarkers for the early detection of pancreatic ductal adenocarcinoma ...

Pancreatic Reference Set Application: Kazufumi Honda-National Cancer Center (2014)

PI: Honda, Kazufumi

Among human malignancies, invasive ductal adenocarcinoma of the pancreas has the worst prognosis,with a 5-year survival rate of less than 10%. Most patients ...

Pancreatic Reference Set Application: Michael Hollingsworth-University of Nebraska (2014)

PI: Hollingsworth, Michael

Pancreatic Reference Set Application: Surinder Batra- University of Nebraska (2014)

PI: Batra, Surinder

To explore the diagnostic significance of the most differentially overexpressed secretory mucin MUC4 and MUC5AC for early detection

Polyp Prediction Study

PI: Meltzer, Stephen

Preliminary Clinical Characterization of Serum Biomarkers for Colorectal Neoplasms

PI: Brenner, Dean

Prevalidation for Rectal PWS for Colon Cancer Screening

PI: Roy, Hemant K.

Prognostic Markers in Lynch Syndrome Colorectal Cancers

PI: Lynch, Henry

Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers

PI: Semmes, John

Screen Detection of Mismatch Repair Deficient Colorectal Neoplasias Using a Stool Based DNA Analysis

PI: Lynch, Henry

Spectral Markers for Early Detection of Colon Neoplasia

PI: Roy, Hemant K.

Standard Specimen Reference Set: Liver

PI: Parikh, Neehar

Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC

Standard Specimen Reference Set: Pancreatic

PI: Brand, Randall E.

The primary objective of the EDRN Pancreatic Cancer Working Group Proposal is to create a reference set consisting of well-characterized serum/plasma specimens ...

Standard Specimen Reference Set: Colon

PI: Brenner, Dean

The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, ...

Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis

PI: Markowitz, Sanford

Colon cancer is the second leading cause of cancer death in the United States. A key issue in treating colon cancer patients is inability to accurately predict ...

Using the methylome to identify aggressive Barrett’s esophagus

PI: Grady, William

OVERALL STRATEGY: Our strategy will consist of using HumanMethylation450 arrays to identify methylation profiles and/or candidate methylated genes that ...

Validation of Biomarkers for the Early Detection of Colorectal Adenocarcinoma (GLNE 010)

PI: Brenner, Dean

We propose a Phase 2 (large cross-sectional) PRoBE-compliant validation trial of stool-based and serum-based tests for the detection of colorectal neoplasia ...

Validation of Serum Markers for the Early Detection of Hepatocellular Carcinoma

PI: Parikh, Neehar

Using the guidelines for cancer biomarker validation suggested by Pepe et al. (23), we propose to perform a Phase 2 study of DCP for the detection of early ...

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