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Biomarkers
ACKR3
ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not ...
ACTR3
The ACTR3 protein is a component of the ARP2/3 complex, which is essential to cell shape and motility.
ADAM12
ADAM12 is a member of the ADAM (a disintegrin and metalloprotease) protein family. ADAM family members are membrane-anchored proteins structurally related to ...
ADH5
ADH5 is a member of the alcohol dehydrogenase family. This protein forms a homodimer. ADH5 is ineffective in oxidizing ethanol, but exhibits high activity for ...
ADIPOQ
From NCBI Gene: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. ...
AFP
AFP is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with ...
AGRN
Agrin is a neuronal aggregating factor that induces the aggregation of acetylcholine receptors and other postsynaptic proteins on muscle fibers and is crucial ...
AKR1B1
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member ...
AKR1C2
From NCBI Gene: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes ...
ALG10
ALG10 is a membrane associated protein found in the endoplasmic reticulum. It is responsible for adding the third glucose residue to the lipid-linked ...
ALPL
From NCBI Gene: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue ...
AMBP
AMBP, a secreted protein, is cleaved into three chains: Alpha-1-microglobulin, Inter-alpha-trypsin inhibitor light chain and Trypstatin. Inter-alpha-trypsin ...
AMY2A
AMY2A, a secreted protein, is an amylase isoenzyme produced by the pancreas. Amylases hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and ...
ANO1
ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to ...
ANXA1
Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. ...
ANXA2
ANXA2, a member of the annexin family, is a calcium-dependent phospholipid-binding protein that plays a role in the regulation of cellular growth and in signal ...
AP3B2
AP3B2 is the beta 2 subunit of adaptor-related protein complex 3, a neuron-specific complex that is thought to serve neuron-specific functions such as ...
APAF1
APAF1 is a cytoplasmic protein that initiates apoptosis. APAF1 binds cytochrome c and dATP, forming an oligomeric apoptosome. The apoptosome binds and ...
APCS
APCS, a secreted glycoprotein found in serum and urine, interacts with DNA and histones and may scavenge nuclear material released from damaged circulating ...
APOA1
APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for ...
APOB
APOB, a secreted glycoprotein, is the main apolipoprotein of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). It occurs in plasma as two main ...
APOC4
APOC4, a member of the apolipoprotein C4 family, is a secreted lipid-binding protein purported to be involved in the metabolism of lipoproteins. Polymorphisms ...
ARHGEF16
ARHGEF16 is a guanine nucleotide exchange factor. Guanine nucleotide exchange factors regulate the activation of Rho-like GTPases. Guanidine ...
ATF3
ATF3 is a member of the the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. The ATF3 ...
ATHL1
ATHL1 belongs to the glycosyl hydrolase 65 family.
ATP6AP1
ATP6AP1 is an integral membrane protein composed of at least 10 subunits. It is responsible for acidifying various eukaryotic intracellular organelles. ...
ATP6AP2
ATP6AP2 functions as a renin and prorenin cellular receptor. It may mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the ...
ATP6V1G1
ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular ...
B2M
B2M, a secreted protein belonging to the beta-2-microglobulin family, is a component of the class I major histocompatibility complex (MHC) on the surface of ...
BANK1
BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. It also promotes ...
BCAM
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin alpha-5. The ...
BCL2L2
From NCBI Gene: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and ...
BDNF
BDNF (brain-derived neurotrophic factor) is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of ...
BGLAP
BGLAP, also known as osteocalcin, makes up 1-2% of the total bone protein. It also binds strongly to apatite and calcium.
BLVRB
BLVRB, a cytoplasmic protein, is a broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, ...
BMX
BMX, or BMX non-receptor tyrosine kinase, belongs to the Tec kinase family. BMX, a non-receptor tyrosine kinase, plays a central but diverse modulatory role in ...
BRCA1
BRCA1 is a nuclear phosphoprotein that functions as a tumor suppressor. BRCA1 combines with other tumor suppressors, DNA damage sensors, and signal ...
C15orf48
C15orf48 is expressed mainly in adult stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. The gene was first identified in ...
C3
Complement component C3, a secreted protein found in plasma, plays a central role in the activation of complement system. Its activation is required for both ...
CA125
MUC16 (CA125) is a highly glycosylated sialomucin that is expressed on epithelial cell surface, especially on ovarian cancer cells. MUC16 is anchored to the ...
CA15-3
From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role ...
CA19-9
CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker ...
CA72-4
High-MW mucin-type glycoprotein expressed on epithelial cancer cells.
CADM1
CADM1, a single-pass type 1 cell membrane protein, appears to be involved in several biolotical processes: Apoptosis, Cell adhesion, Differentiation, Immunity ...
CBLC
CBLC is a nuclear protein which interacts with a restricted range of of SH3 domain proteins and regulates EGFR mediated signal transduction. CBLC is ...
CCDC102B
CCDC102B, or coiled-coil domain-containing protein 102B, has two isoforms produced by alternative splicing.
CCL11
From NCBI Gene: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted ...
CCL13
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of ...
CCL17
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of ...
CCL2
From NCBI Gene: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved ...
CCL22
From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of ...
CCL26
From NCBI Gene: This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins ...
CCL27
CCL27 is a member of the CC cytokine family, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two ...
CCL28
CCL28 is a member of the small cytokine CC subfamily, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two ...
CCL4
From NCBI Gene: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The ...
CCL5
From NCBI Gene: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins ...
CCND1
CCND1 is a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell ...
CD1A
CD1A is a transmembrane glycoprotein that is structurally related to the major histocompatibility complex (MHC) proteins and forms heterodimers with ...
CD248
CD248 is a 165-kD cell surface glycoprotein expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. There is also ...
CD59
CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. CD59 is a potent inhibitor ...
CDCP1
CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is ...
CDH1
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein ...
CDH3
From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein ...
CEACAM5
From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the ...
CHGA
From NCBI Gene: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in ...
CHI3L1
CHI3L1, also known as chitinase, a secreted protein, is a carbohydrate-binding lectin with a preference for chitin. It may play a role in defense against ...
CKM
CKM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. It reversibly catalyzes the transfer of ...
COX7A1
COX7A1, cytochrome c oxidase subunit VIIa polypeptide 1 (muscle), is one of the polypeptide chains of cytochrome c oxidase, the terminal component of the ...
CPA4
The gene for CPA4 encodes a protein that is a member of the carboxypeptidase A/B subfamily. The CPA4 gene is located in a cluster with three other family ...
CPXCR1
CPXCR1 is located in a region on the X chromosome that has been associated with X-linked cleft palate (CPX) disorder. CPXCR1 contains a motif found in several ...
Cramer 5-marker panel for ovarian cancer
The PLCO phase III specimens (test half) revealed marker panels produced only marginal improvement over CA 125 alone and, in some case, worse performance. ...
CRIP1
CRIP1 appears to have a role in intestinal zinc absorption and may function as an intracellular zinc transport protein. It belongs to the LIM/double zinc ...
CRIP2
Cysteine-rich intestinal protein 2 (CRIP2) has been shown to be involved in development. It is expressed in a variety of tissues, with particularly high ...
CRP
From NCBI Gene: The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability ...
CRTAC1
CRTAC1, a secreted protein, is expressed in the interterritorial matrix of articular deep zone cartilage. There are three isoforms for CRTAC1; isoform 1, ...
CRYAB
From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and ...
CSF1
From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and ...
CSNK1E
CSNK1E is a serine/threonine protein kinase and a member of the casein kinase I protein family. Casein kinases are characterized by their preferential ...
CSRP2
CSRP2 encodes a LIM domain protein. LIM domain proteins may be involved in regulatory processes important for development and cellular differentiation. CSRP2 ...
CST6
CST6, a type 2 cystatin protein, is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated ...
CTBP1
From NCBI Gene: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may ...
CTCFL
CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, belongs to the CTCF zinc-finger protein family. CTCFL is responsible for ...
CTGF
CTGF, a major connective tissue mitoattractant secreted by vascular endothelial cells, promotes proliferation and differentiation of chondrocytes. It mediates ...
CXCL10
From NCBI Gene: This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in ...
CXCL8
CXCL8, commonly known as IL8, is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that ...
DAG1
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, ...
DAPL1
DAPL1 is expressed in hair folicles and may play a role in the early stages of epithelial differentiation or in apoptosis.
DBT
From NCBI Gene: The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the ...
DEFB1
DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the ...
DGCR6
DGCR6 is located on chromosome 22q11.21. Microdeletions in this region are associated with DiGeorge syndrome, and more widely, the CATCH 22 syndrome. DGCR6, ...
DKK3
DKK3, a member of the dickkopf family, is a secreted protein containing two cysteine rich regions and involved in embryonic development through its ...
DNAJC7
DNAJC7 is a member of the DNAJ heat shock protein 40 family. This family is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal ...
DSC2
DSC2, a calcium-dependent glycoprotein, is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the ...
DSG2
DSG2 is a calcium-binding transmembrane glycoprotein component of intercellular desmosome junctions in vertebrate epithelial cells. It is involved in the ...
DUSP9
DUSP9 is a member of the dual specificity protein phosphatase subfamily. DUSP9 is specific for members of the ERK family of MAP kinases, is expressed only in ...
ECM1
ECM1 is an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains ...
EED
EED is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional ...
EFEMP1
EFEMP1, also known as fibulin-3, binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. It ...
EFNA5
EFNA5 is a cell surface-bound member of the ephrin gene family. Ephrins are proteins that function as ligands for the ephrin receptors (Eph receptors). Eph ...
EFR3A
EFR3A (KIAA0143) is a membrane protein. Little is known about its function, although studies on the mouse homolog have suggested a role in hearing. It has ...
EGFL6
EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the ...
EGFR
From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor ...
EIF3E
From UniProtKB/Swiss-Prot: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation ...
ELF2
ELF2 is a nuclear protein that is conserved across several species. Multiple isoforms have been identified. Isoform 1 transcriptionally activates the LYN and ...
EMILIN2
EMILIN2, a secreted protein, may be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the ...
ENG
ENG, or endoglin, is a cell surface adhesion protein involved the regulation of angiogenesis. ENG is a major glycoprotein of the vascular endothelium and is ...
EP300
EP300, or E1A binding protein p300, functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. EP300 is important in the ...
EPB41L3
EPB41L3 protein is a critical growth regulator in the pathogenesis of meningiomas. There are three isoforms of this protein, produced by alternative splicing.
EPCAM
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. The EPCAM antigen, a ...
EPSTI1
EPSTI1 is highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. There are three isoforms of this protein, ...
ERBB2
From NCBI Gene: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand ...
ESM1
ESM1, a secreted protein containing multiple polyadenylation and mRNA instability signals, may have potent implications in lung endothelial cell-leukocyte ...
FABP5
From NCBI Gene: This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. ...
FAM83H
FAM83H is a member of the FAM83 family and plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a ...
FAS
FAS is a member of the TNF-receptor superfamily. The FAS protein is a receptor for TNFSF6/FASLG and has been shown to play a central role in the ...
FBLN1
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its ...
fbpA
FGF2
From NCBI Gene: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad ...
FGFR4
FGFR4, a single-pass membrane protein, acts as a receptor for acidic fibroblast growth factor. It binds FGF19, and does not bind to basic fibroblast growth ...
FIGF
From NCBI Gene: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is ...
FJX1
FJX1 is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and ...
FLT1
From NCBI Gene: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine ...
FLT3LG
From NCBI Gene: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune ...
FNDC3A
Fndc3a is a member of a three-gene family in mice. Mouse Fndc3a is composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a ...
FOLH1B
FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related ...
FOLR1
FOLR1 is a cell membrane protein that binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of ...
FRS3
From NCBI Gene: This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and ...
FSH
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. ...
FSTL1
FSTL1, a protein similar to follistatin, an activin-binding protein, contains an FS module, a follistatin-like sequence containing 10 conserved cysteine ...
FZD10
FZD10 is a member of the frizzled gene family. The frizzled gene family encodes 7-transmembrane domain proteins that are receptors for the Wingless type MMTV ...
GCLM
From NCBI Gene: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The ...
GDF15
GDF15, also known as macrophage inhibitory cytokine 1, or MIC1, is a bone morphogenetic protein (BMP) belonging to the transforming growth factor-beta ...
GFPT1
GFPT1 is the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. It appears to catalyze the ...
GH1
Growth hormone, a secreted protein which exists as a monomer, dimer, trimer, tetramer and pentamer and is disulfide-linked or non-covalently associated in ...
GLO1
From NCBI Gene: The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and ...
GLOD4
GLOD4 belongs to the glyoxalase I family. It is expressed in heart, brain, liver, kidney, pancreas and placenta; it is not expressed in skeletal muscle and ...
GM2A
GM2A, a small glycolipid transport protein, acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, ...
GNB4
GNB4 is the beta subunit of a heterotrimeric guanine nucleotide-binding protein (G protein). These proteins also have alpha and gamma subunits. GNB4 and other ...
GPANK1
GPANK1, also known as BAT4, is part of a cluster of genes, BAT1-BAT5. These genes are HLA-B associated transcripts, and are included in the human major ...
GPI
From NCBI Gene: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein ...
GPKOW
GPKOW is a a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. GPKOW interacts directly with protein kinase A ...
GPM6B
GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is ...
GPR157
GPR157 is a multi-pass transmembrane G protein-coupled receptor protein. GPR157 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and ...
GPR158
GPR158, a multi-pass cell membrane protein, belongs to the G-protein coupled receptor 3 family.
GPR39
The GPR39 (a multi-pass cell membrane protein) receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second ...
GPR65
GPR65, a member of the G-protein coupled receptor 1 family, is a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. ...
GRN
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine ...
GSTM1
From NCBI Gene: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct ...
GSTM2
From NCBI Gene: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct ...
H2AFJ
H2AFJ is a core component of the nucleosome. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 ...
H2AFV
H2AFV is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. The nucleosome is a histone octamer containing two molecules each of ...
HAMP
HEPC, also known as HAMP, is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for ...
HAPLN1
This widely expressed protein stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
HE4
11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of ...
HEXIM1
HEXIM1 is an intronless transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. HEXIM1 expression is induced by ...
HGF
From NCBI Gene: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after ...
HIST1H2AA
HIST1H2AA, a member of the histone 2A family, is a core component of the nucleosome. The nucleosome is a histone octamer containing two molecules each of H2A, ...
HMGB1
Nuclear protein HMGB1 is a DNA-binding protein that associates with chromatin and has the ability to bend DNA. It binds preferentially single-stranded DNA. ...
HOXA9
HOXA9 is a sequence-specific transcription factor. It is a member of the homeobox gene family. These transcription factors are spatially and temporally ...
HOXD1
From NCBI Gene: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a ...
HSD17B10
HSD17B10, hydroxysteroid (17-beta) dehydrogenase 10, is a member of the short-chain dehydrogenase/reductase superfamily. HSD17B10 functions in mitochondrial ...
HSPG2
HSPG2, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached, is a large ...
HTRA1
HTRA1, a member of the trypsin family of serine proteases, is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors ...
ICAM1
From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to ...
IDH1
IDH1 is an NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The ...
IFI27
IFI27, a multi-pass membrane protein, promotes cell death. It mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from ...
IFNG
From NCBI Gene: This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and ...
IGF2
IGF2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. The IGF2 gene is an imprinted gene and is ...
IGFBP1
IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a ...
IGFBP2
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell ...
IGFBP3
The IGFBP3 gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a secreted protein with an IGFBP domain and a ...
IGFBP4
The IGFBP4 gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin ...
IL10
From NCBI Gene: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has ...
IL12
The cytokine IL12, also known as IL12-p70, is the heterodimer formed by the protein products of the IL12A and IL12B genes. IL12A has a molecular weight ...
IL13
From NCBI Gene: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell ...
IL18
From NCBI Gene: The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates ...
IL1B
From NCBI Gene: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a ...
IL2
From NCBI Gene: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of ...
IL2RA
The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of ...
IL4
From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. ...
IL5
From NCBI Gene: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays ...
IL6
Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In ...
IL6R
The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal ...
ITGB1
ITGB1 is a beta subunit of the heterodimeric integrin protein. Integrins are ubiquitously expressed adhesion molecules composed of alpha and beta subunits. ...
ITGBL1
ITGBL1, or integrin, beta-like 1 (with EGF-like repeat domains), is a member of the EGF-like protein family. It is a beta integrin-related protein containing ...
ITIH4
The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five ...
JUNB
JUNB, or jun B proto-oncogene, is a transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA ...
KCP
KCP is a secreted protein that enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. KCP is also thought to inhibit both the activin-A and ...
KDR
From NCBI Gene: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of ...
KIT
SCF-sR, also known as KIT, is the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma ...
KLHL14
KLHL14 is a 628 amino acid protein containing one BTB (POZ) domain and six Kelch repeats involved in protein binding.
KLK6
Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control ...
KLK8
KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin ...
KRT19
KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. ...
KRT8
From NCBI Gene: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to ...
LAMA5
LAMA5 belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have ...
LAMB2
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into ...
LAPTM4B
LAPTM4B, a multi-pass membrane protein and part of the endomembrane system, belongs to the LAPTM4/LAPTM5 transporter family. There is little documentation ...
LBP
From NCBI Gene: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative ...
LCP2
LCP2, previously known as SLP76, functions as an adaptor or scaffolding protein. LCP2 has three modular domains. The amino-terminal end has an acidic region ...
LEP
Leptin (LEP) is secreted by white adipocytes and plays a major role in the regulation of body weight. This protein, which acts through the leptin ...
LGALS3BP
LGALS3BP is a secreted protein that binds to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. Elevated levels of LGALS3BP have ...
LHB
The pituitary glycoprotein hormone family includes follicle stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG), and ...
LPAR3
LPAR3, a multi-pass cell membrane protein, is a receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. LPAR3 seems to be coupled ...
LRG1
The leucine-rich repeat (LRR) family of proteins, including secreted protein LRG1, have been shown to be involved in protein-protein interaction, signal ...
LRRC47
LRRC47 contains 7 LRR (leucine-rich) repeats. It is purportedly involved in (by similarity) RNA binding, translation and phenylalanine-tRNA ligase activity.
LTBP1
LTBP1 is a secreted protein that may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. It may play ...
LTBP2
LTBP2, the largest member of the latent transforming growth factor (TGF)-beta binding protein family, possesses unique regions and is most similar to the ...
LY6G6C
LY6G6C, a cell membrane protein, is highly expressed at the leading edges of cells, on filopodia. The LY6G6C gene belongs to a cluster of leukocyte antigen-6 ...
LZTS1
LZTS1 is a tumor suppressor protein that is widely expressed in normal tissues. It is involved in regulating cell growth and is also thought to interact with ...
MAGEA4
From NCBI Gene: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. ...
MAGEA6
The members of the MAGEA protein family display 50-80% sequence identity among their members. MAGEA proteins are thought to play a role in tumor ...
MAP2K1
MAP2K1, or mitogen-activated protein kinase kinase 1, is a dual specificity protein kinase which acts as an essential component of the MAP kinase signal ...
MAPK14
From NCBI Gene: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical ...
MBD1
From NCBI Gene: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). ...
MET
From NCBI Gene: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain ...
MIF
MIF, a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation, plays a role in the regulation of macrophage function in host defense ...
MMP1
From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, ...
MMP10
From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, ...
MMP2
MMP2 is a member of the matrix metalloproteinase (MMP) family and is involved in many functions, such as remodeling of the vasculature, angiogenesis, tissue ...
MMP3
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as ...
MMP7
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as ...
MMP9
MMP9 is a member of the matrix metalloproteinase (MMP) family. It is a secreted protein that may play an essential role in local proteolysis of the ...
MPO
Myeloperoxidase (MPO) is a lysosomal heme protein found at chromosomal location 17q23.1. It is produced as a single chain precursor that is cleaved into two ...
MPPED2
MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). ...
MPZL2
The EVA1, or MPZL2 gene is expressed in the thymus and in several epithelial structures early in embryogenesis. The protein MPZL2 displays an ability to ...
MSLN
Mesothelin, a cell surface antigen, was isolated using an antibody that reacts with ovarian cancers and mesotheliomas. Although the function of mesothelin is ...
MXRA5
MXRA5, one of the matrix-remodelling associated proteins, contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. It is ...
MYC
The oncogenic protein MYC, previously known as c-MYC, is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and ...
MYCBP
MYCBP, or MYC binding protein, or C-MYC binding protein, binds to the N-terminus of the oncogenic protein MYC, also known as C-MYC, enhancing the ability ...
MYO5A
The MYO5A gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. The MYO5A protein functions as a processive actin-based ...
MYOZ2
From NCBI Gene: The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in ...
NDUFA10
NDUFA10 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in ...
NID1
NID1, a sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin, is a member of the nidogen family of basement ...
NID2
NID2 is a member of the nidogen family of basement membrane proteins. It is a cell adhesion glycoprotein that binds collagens I and IV and laminin. NID2 may ...
NME2
From NCBI Gene: Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) ...
NMU
NMU, a secreted protein belonging to the NmU family, stimulates muscle contractions of the ileum and urinary bladder. It is expressed throughout the enteric ...
NOS1
NOS1, or nitric oxide synthase 1 (neuronal), along with inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3), catalyze the ...
NPC2
NPC2, a secreted protein containing a lipid recognition domain, may function in regulating the transport of cholesterol through the late endosomal/lysosomal ...
NUCB1
NUCB1, a major calcium-binding protein of the Golgi, is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction ...
ODC1
From NCBI Gene: This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level ...
OLFML2B
OLFML2B is a secreted protein. The gene is conserved across many species. The protein is a homodimer.
OVA1
The OVA1 diagnostic test is comprised of five biomarkers: CA125, transthyretin (prealbumin), apolipprotein A1 (Apo A-1), beta-2 microglobulin, and transferrin. ...
OVGP1
OVGP1, a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem ...
p16
The CDKN2A locus generates several transcript variants which differ in their first exons. Two distinct transcripts are produced from different promoters: p16 ...
P2RY14
P2RY14, or GPR105, is a G-protein coupled receptor that responds to extracellular purine and pyrimidine nucleotides. P2RY14 is not activated by ATP, ADP, ...
PCCA
PCCA, or propionyl CoA carboxylase, alpha polypeptide, is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. The beta ...
PCDH17
PCDH17 is a member of the protocadherin gene family, a subfamily of the cadherin superfamily. PCDH17 has six extracellular cadherin domains, a transmembrane ...
PCOLCE
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide ...
PCSK9
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 is synthesized as a soluble zymogen that ...
PDCD6IP
From NCBI Gene: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle ...
PDGFA
PDGFA, or platelet-derived growth factor alpha polypeptide, is a member of the platelet-derived growth factor family. PDGFA is a growth factor that plays an ...
PEBP1
PEBP1 is a cytoplasmic protein that binds ATP, opioids and phosphatidylethanolamine. It has lower affinity for phosphatidylinositol and phosphatidylcholine. ...
PEX11B
PEX11B, or peroxisomal biogenesis factor 11 beta, is involved in peroxisomal proliferation and interacts with PEX19. PEX11B is located in the peroxisomal ...
PFAS
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to ...
PI3
ELAFIN, a secreted protein, is a neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. ELAFIN ...
PIGF
From NCBI Gene: This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three ...
PLEC
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable ...
PLTP
PLTP is a secreted protein that converts HDL into larger and smaller particles. It may play a key role in extracellular phospholipid transport and modulation ...
PLXNB1
PLXNB1, a receptor for SEMA4D, plays roles in RHOA activation and subsequent changes of the actin cytoskeleton, axon guidance, invasive growth and cell ...
PNP
PNP, a cytoplasmic protein, is an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three ...
POLQ
POLQ belongs to the DNA polymerase type-A family and has one helicase ATP-binding domain and one helicase C-terminal domain. POLQ has a DNA polymerase activity ...
POLR2L
POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This ...
POSTN
POSTN, a secreted protein, binds to heparin and induces cell attachment and spreading. It may additionally play a role in cell adhesion and in extracellular ...
PPBP
CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant ...
PPP2R4
From NCBI Gene: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. ...
PRDX4
From NCBI Gene: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. ...
PRDX6
PRDX6, a cytoplasmic homotetramer, is a member of the thiol-specific antioxidant protein family. It is a bifunctional enzyme with two distinct active sites. It ...
PRL
There is increasing evidence that prolactin (PRL), a hormone/cytokine, plays a role in breast, prostate, and colorectal cancers via local production or ...
PRMT1
PRMT1 is an arginine N-methyltransferase that functions as a histone methyltransferase specific for H4. Together with dimethylated PIAS1, it represses STAT1 ...
PROS1
PROS1 is a secreted vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood ...
PSA
KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily ...
PSAP
The PSAP gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor ...
PSAT1
From NCBI Gene: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine ...
PTCHD1
PTCHD1 is a membrane protein with a patched domain that is similar to Drosophila proteins which act as receptors for the morphogen sonic hedgehog. Deletions in ...
PTH2R
PTH2R, a member of the G-protein coupled receptor family 2, is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition ...
PTK7
PTK7, a single-pass type I membrane protein, is an inactive tyrosine kinase involved in Wnt signaling pathway. It is a component of both the non-canonical ...
PTPMT1
PTPMT1 is a lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the ...
PTPN11
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTP family members are a group of enzymes that catalyze the removal of phosphate groups ...
PTPRC
PTPRC is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular ...
PTPRE
PTPRE is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular ...
PTPRS
PTPRS, a single-pass type I membrane protein, interacts with LAR-interacting protein LIP.1. PTPRS is a member of the protein tyrosine phosphatase (PTP) family. ...
PVRL4
The PVRL4 protein, also known as nectin-4, is a member of the nectin family. PVRL4 contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like ...
QSOX1
QSCN6 contains domains of thioredoxin and ERV1, members of two long-standing gene families. QSCN6 catalyzes the oxidation of sulfhydryl groups in peptide and ...
RAB13
RAB13 is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling ...
RAB24
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking. RAB24 may be involved in ...
RAB5A
From UniProtKB/Swiss-Prot: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their ...
RAC1
From NCBI Gene: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily ...
RAC3
From NCBI Gene: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily ...
RGS5
RGS5 is a member of the regulators of G protein signaling (RGS) family, which are signal transduction molecules that are involved in the regulation of ...
RHOA
RHOA is a member of the small GTPase superfamily. RHO family GTPases are involved in many basic cellular processes that influence cell proliferation, ...
RMND5A
RMND5A (FLJ13910) is also known as required for meiotic nuclear division 5 homolog A (S. cerevisiae). There are two isoforms of this human protein, ...
RNF113A
RNF113A is a member of the RNF family, or RING-type zinc finger proteins. The RNF proteins are a subset of the larger family of zinc finger proteins. ...
ROMA
The Risk of Ovarian Malignancy Algorithm (ROMA) algorithm was approved by the FDA in 2011. Research demonstrates that examining levels of HE4 and CA125 ...
S100A4
From NCBI Gene: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are ...
S100A6
From NCBI Gene: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are ...
SAA@
SAA@, or serum amyloid A1 cluster, is a gene cluster.
SAT1
From NCBI Gene: The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine ...
SATL1
SATL1 is a protein coding gene that has been found to be conserved across Rhesus monkey, dog, cow, mouse, rat, and frog. SATL1 shows N-acetyltransferase ...
SCGB2A1
SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is ...
SCNN1A
SCNN1A, a multi-pass membrane protein belonging to the amiloride-sensitive sodium channel family, is a sodium permeable non-voltage-sensitive ion channel ...
SDC1
SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The SDC1 protein functions as an integral ...
SEC23B
SEC23B is a member of the SEC23B/SEC24B family. SEC23B is a component of the COPII coat, that covers ER-derived vesicles involved in transport from the ...
SECTM1
SECTM1 is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and ...
SELENBP1
SELENBP1 belongs to the selenium-binding protein family. SELENBP1 may be involved in the sensing of reactive xenobiotics in the cytoplasm. It may also be ...
SELL
From NCBI Gene and UniProtKB/Swiss-Prot: sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing ...
SERPINA6
SERPINA6, an alpha-globulin protein with corticosteroid-binding properties, is the major transport protein for glucorticoids and progestins in the blood of ...
SERPINB3
Squamous cell carcinoma antigen (SCCA) may act as a protease inhibitor to modulate the host immune response against tumor cells. Present in the cytoplasm of ...
SERPINE1
The SERPINE1 protein is a serine proteinase inhibitor (serpin) superfamily. SERPINE1 is the main inhibitor of tissue plasminogen activator (tPA) and urokinase ...
SERPINH1
From NCBI Gene: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic ...
SF3A1
From NCBI Gene: This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 ...
SFN
From UniProtKB/Swiss-Prot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to ...
SLA
SLA, or Src-like-adaptor, is an adaptor protein involved in negative regulation of T-cell receptor (TCR) signaling and regulation of receptor tyrosine kinase ...
SLAMF8
SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in ...
SLC11A1
SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain ...
SLC25A16
SLC25A16 is a member of the mitochondrial carrier family and contains three tandemly repeated mitochondrial carrier protein domains. The SLC26A16 protein is ...
SLC30A6
SLC30A6 is a zinc-efflux transporter which has been shown by similarity to be involved in distributing the cytoplasmic zinc to the trans-Golgi network (TGN) as ...
SLC33A1
From NCBI Gene: The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 ...
SLPI
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical ...
SMA4
SMA4 glucuronidase, beta pseudogene
SMRP
Soluble mesothelin-related protein (SMRP) is related to the mesothelin family of molecules. It is overexpressed in ovarian cancer, malignant ...
SNRPA1
SNRPA1 is a nuclear protein associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. SNRPA1 has four LRR (leucine-rich) ...
SOD3
SOD3, a protein that is secreted into the extracellular space, forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell ...
SOST
From NCBI Gene: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential ...
SOX2
From NCBI Gene: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic ...
SPINT2
SPINT2, a single-pass type-1 membrane protein, is an inhibitor of HGF activator. It also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. It is ...
SPON1
SPON1, an extracellular matrix protein, is a cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of ...
SPON2
SPON2, also known as spondin-2, is a cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. It binds directly to ...
SPP1
Osteopontin, also known as SPP1 or OPN, a secreted, integrin-binding matrix phosphorylated glycoprotein is involved in bone remodeling by osteoclasts and ...
SPP2
SPP2 is a secreted phosphoprotein that is a member of the cystatin superfamily. It is detected in liver and plasma.
SRP54
SRP54, or signal recognition particle 54kDa, contains a 7S RNA molecule of 300 nucleotides and six protein subunits. SRP54 binds to the signal sequence of ...
SSBP1
SSBP1 is a housekeeping gene that is thought to be involved in mitochondrial DNA replication. SSBP1, or single-stranded DNA-binding protein binds to single ...
ST13
ST13, a cytoplasmic homotetramer protein belonging to the FAM10 family, interacts with HSC70 as well as DNAJ homologs and HSP90. ST13 is an adaptor protein ...
ST14
ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this ...
STAT6
STAT6 is a member of the STAT family of transcription factors. STAT family members are phosphorylated by the receptor associated kinases in response to ...
STOM
STOM, or stomatin, is an integral membrane protein located in the cell membrane of red blood cells and other cell types, where it is thought to regulate ion ...
STOML2
STOML2, also known as SLP-2 or stomatin-like 2, is a mitochondrial protein that is thought to regulate the biogenesis and the activity of mitochondria, and ...
TAGLN2
TAGLN2 is a homolog of the protein transgelin, one of the earliest markers of differentiated smooth muscle. The function of this protein has not yet been ...
TEK
From NCBI Gene: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular ...
TF
TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene ...
TFCP2
From NCBI Gene: This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded ...
TIMP1
The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in ...
TLR2
TLR2, or toll-like receptor 2, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of ...
TNF
TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and ...
TNFAIP1
The expression of this gene can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Mouse studies suggest the expression ...
TNFAIP6
TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly ...
TNFRSF11B
From NCBI Gene: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that ...
TNFRSF1A
TNFRSF1A, one of the major receptors for the TNF-alpha, is a member of the TNF-receptor superfamily. This protein activates NF-kappaB, mediates apoptosis, and ...
TNFRSF1B
TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the ...
TNFRSF21
TNFRSF21, a member of the TNF-receptor superfamily and a single-pass type I membrane protein, has been shown to activate NF-kappaB and MAPK8/JNK, and induce ...
TNFRSF6B
DcR3 belongs to the tumor necrosis factor receptor superfamily and is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. ...
TRAF4
TRAF4 is a member of the TNF receptor associated factor (TRAF) family. Members of the TRAF family are the major signal transducers for the TNF receptor (TNFR) ...
transthyretin
Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid, is a carrier protein that transports thyroid hormones ...
TRIM32
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, ...
TSHB
TSH, a secreted protein belonging to the glycoprotein hormones subunit beta family, is essential for the control of thyroid structure and metabolism. The four ...
TSPO
TSPO is a conserved protein found at the outer mitochondrial membrane. TSPO interacts with some benzodiazepines and isoquinoline carboxamides and has ...
TSSK3
TSSK3 is a testis-specific kinase that is thought to be involved in either germ cell differentiation or mature sperm function.
TSSK4
TSSK4 may be involved in a signaling pathway during male germ cell development or mature sperm function. It phosphorylates CREB1 on Ser-133 and stimulates ...
UBAP1
From NCBI Gene: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. ...
UPP1
UPP1, or uridine phosphorylase 1, is a pyrimidine nucleoside phosphorylase. UPP1, in the presence of orthophosphate, catalyzes the reversible phosphorylytic ...
VCAM1
VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, is a cell surface sialoglycoprotein expressed by cytokine-activated ...
VCAN
VCAN, or CSPG2, a large chondroitin sulfate proteoglycan, is a major component of the extracellular matrix. This secreted protein is involved in cell adhesion, ...
VEGFA
Vascular endothelial growth factor (VEGFA or VEGF) is a growth factor and signaling protein involved in the regulation of angiogenesis, vasculogenesis, and ...
VEGFC
From NCBI Gene: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The ...
VTA1
VTA1 (C6ORF55) is involved in activities of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in ...
VTCN1
Highly glycosylated sialomucin; expressed on immune cells. Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, ...
VWF
Important in the maintenance of hemostasis, VWF, a secreted protein found in extracellular space, promotes adhesion of platelets to the sites of vascular ...
WNT10A
WNT10A, a probable developmental protein, is a ligand for members of the frizzled family of seven transmembrane receptors. It may be a signaling molecule ...
WWC1
WWC1, or KIBRA, is a cytoplasmic phosphoprotein. Expression has been detected in the brain, heart, colon and kidney, as well as mammary epithelial cells ...
XBP1
XBP1 is a transcription factor involved in hepatocyte growth, differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response ...
XPOT
XPOT, or exportin-T, belongs to the RAN-GTPase exportin family. This protein facilitates export of tRNA from the nucleus to the cytoplasm. XPOT shuttles ...
YEATS4
YEATS4 has high sequence similarity to human MLLT1, and yeast and human MLLT3 proteins, both transcription factors, and is therefore hypothesized to be a ...
ZFP36L1
ZFP36L1 is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide ...
ZMYM6
ZMYM6 is an MYM zinc finger protein. Zinc fingers are DNA binding proteins located in the cell nucleus.
ZNF510
ZNF510 is a zinc finger protein thought to be involved in transcriptional regulation.
Projects/Protocols

Projects

There are currently no projects of which this group is a part.

Protocols

Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer

PI: Cramer, Daniel

Assessment of Clinical Potential of Digital SNP Analysis

PI: Helzlsouer, Kathy

BBD Reference Set Application: Jeffery Marks-Duke (2015)

PI: Marks, Jeffrey

We propose a pre-validation study for markers that could predict the likelihood of invasive breast cancer following a tissue diagnosis of benign breast ...

BRSCW Reference Set Application: Anna Lokshin - Univ of Pitts (2008)

PI: Lokshin, Anna

Validate biomarkers identified using Luminex bead-based arrays in case/control sets (individual samples) in reference sets

BRSCW Reference Set Application: Anu Mathew - Meso Scale (2006)

PI: Mathew, Anu

46 markers were tested on pooled case samples and on control samples.

BRSCW Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)

PI: Diamandis, Eleftherios P.

Examine kallikreins as ovarian cancer biomarkers

BRSCW Reference Set Application: GeorgeTuszynski - Temple University (2012)

PI: Tuszynski, George

The marker GASP-1 was evaluated in the pooled breast cancer reference set. It did not seem to be elevated relative to controls.

BRSCW Reference Set Application: James Morre - NOX Technologies Inc. (2009)

PI: Morre, D. James

Evaluation using NOX Technologies ECTO-NOX blot diagnostic 2-D gel electrophoretic cancer detection system in combination with a sandwich ELISA of our ...

BRSCW Reference Set Application: Joe Buechler - Biosite Inc (2009)

PI: Buechler, Joe

Over 40 marker assays are available to run on the samples. These include markers such as Osteopontin, Mesothelin, Periostin, Endoglin, intestinal Fatty Acid ...

BRSCW Reference Set Application: Karen Abbott -University of Arkansas (2014)

PI: Abbott, Karen

Our earlier glycoproteomic studies have identified bisecting glycoslyation and core fucosylation changes on particular glycoproteins in endometrioid ovarian ...

BRSCW Reference Set Application: Michael Birrer-Massachusetts General Hospital (2013)

PI: Birrer, Michael

Validate FGF18 and GPR172A in reference set

BRSCW Reference Set Application: Michael Wilson - EIC Laboratories, Inc (2007)

PI: Wilson, Michael S.

The selected markers are well established as "standard" markers fo ra range of cancers, and have been analyzed in the reference set as a benchmark for ...

Benign Breast Disease Team Project

PI: Engstrom, Paul

To identify women diagnosed with atypical ductal hyperplasia (ADH) who are at increased risk of developing invasive breast cancer (IBC) and who might benefit ...

Biomarker Detection Using NAPPA Tumor Antigen Arrays

PI: LaBaer, Joshua

The overall goal of this project is to identify autoantibody biomarkers in sera that can be readily used for the early detection of cancers

Biomarker Detection Using NAPPA Tumor Antigen Arrays: EDRN Supplement

PI: Anderson, Karen

The overall goal of this project application for the EDRN set-aside funds is to focus our collaborative efforts to identify p53 mutation-specific antibody ...

Biomarker Development Laboratory

PI: Zhao, Yingming

Biomarker Reference Sets for Cancers in Women

PI: Cramer, Daniel

The purpose of this study is to develop a standard reference set of specimens for use by investigators participating in the National Cancer Institutes Early ...

Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancer

PI: Li, Christopher

Distinguishing aggressive cancers from non-aggressive or non-progressing cancers is an issue of both clinical and public health importance particularly for ...

Body Fluids as a Source of Diagnostic Biomarkers: Breast

PI: Semmes, John

Breast Cancer: subgroups specific blood-biomarkers for early / predictive diagnosis and personalized treatment

PI: Golubnitschaja, Prof. Dr. Olga

Breast-conserving lumpectomy followed by radiation therapy has been shown to be an alternative strategy, competitive to mastectomy, in preventing mortality ...

Breast Ductal Lavage Fluid Specimen Bank

PI: Trock, Bruce

Breast Reference Set Application: Anu Mathew-Meso Scale (2012)

PI: Mathew, Anu

Using a subset of plasma samples (n=505) from the reference set, we analyzed 90 proteins by multiplexed immunoassays for their potential utility as diagnostic ...

Breast Reference Set Application: Chris Li-FHCRC (2014)

PI: Li, Christopher

This application proposes to use Reference Set #1. We request access to serum samples collected at the time of breast biopsy from subjects with IC (n=30) or ...

Breast Reference Set Application: Chris Li-FHCRC (2015)

PI: Li, Christopher

We propose to evaluate nine candidate biomarkers for ER+ breast cancer in samples from the EDRN Breast Cancer Reference Set. These biomarkers have been ...

Breast Reference Set Application: GeorgeTuszynski-Temple (2012)

PI: Tuszynski, George

As recommended by the review committee, we will analyze 30 invasive cancer cases and 30 benign controls from the EDRN breast reference set. Cases and controls ...

Breast Reference Set Application: Karen Abbott- University of Arkansas (2013)

PI: Abbott, Karen

We are evaluating whether detection of a tumor-specific N-linked glycosylation known as B 1,6 branched N-glycan present on the glycoprotein periostin in breast ...

Breast Reference Set Application: Karen Anderson-ASU (2014)

PI: Anderson, Karen

In order to increase the predictive value of tumor-specific antibodies for use as immunodiagnostics, our EDRN BDL has developed a novel protein microarray ...

Breast Reference Set Application: Pinku Mukherjee-CanDiag (2014)

PI: Mukherjee, Pinku

We would like to get all three sets of specimens, however, we are requesting Specimen Set 1 first: 30 subjects with invasive cancer and 30 subjects with benign ...

Breast Reference Set Application: Richard Zangar-PNNL (2012)

PI: Zangar, Richard (Rick) C.

Our immediate goal is to define a set of biomarkers (composed of circulating plasma proteins) that can be used to distinguish between true and false screens, ...

Breast tissue array

PI: Chia, David

CLUE Studies: Evaluating Biomarkers of Carcinogenesis

PI: Helzlsouer, Kathy

Clinical Validation of Molecular Signatures of Cervical Neoplasia

PI: Unger, Elizabeth R.

DCIS Team Project

PI: Li, Christopher

Both overtreatment and undertreatment of DCIS are pervasive problems given that no useful approaches for identifying which DCIS patients are likely or highly ...

Detecting Breast Cancer Signatures in Body Fluids

PI: Trock, Bruce

Detecting breast cancer protein signatures in body fluid

PI: Semmes, John

Detection of Serum Markers of Breast Cancer by SELDI

PI: Marks, Jeffrey

Detection of Serum Proteomic Patterns and SNPs in Breast Cancer: A Pilot Study

PI: Esserman, Laura J.

Development of FISH-based assay for early detection of high grade cervical dysplasia

PI: Unger, Elizabeth R.

Development of paraffin-based expression profiles to predict minimal vs. substantial risk of disease progression using retrospective datasets

PI: Esserman, Laura J.

EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project

PI: Li, Christopher

To identify promising candidate plasma early detection biomarkers specific to different molecular subtypes of breast cancer using preclinical specimens from ...

EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial

PI: Li, Christopher

Over 70% of women with ovarian/fallopian tube cancer (OC) are diagnosed with advanced stage disease which has a 5-year relative survival rate of 30%. Five-year ...

EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples

PI: Li, Christopher

We will collaborate with investigators from University College London to test a screening decision rule in preclinical serial samples from the U.K. ...

EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples

PI: Li, Christopher

The WHI offers an opportunity to evaluate ovarian cancer markers and screening decision rules developed and validated in EDRN CVC Studies 2 and 3 in women who ...

EDRN Longitudinal Serum Biorepository

PI: Lynch, Henry

Four percent of EDRN Registry mutation carriers developed cancer within a year after beginning follow-up in this registry; within 2 years, 10% had developed ...

Early Detection Research Network Registry for Hereditary Cancer

PI: Lynch, Henry

The EDRN High Risk Registry (HRR)recruits individuals that carry germline mutations for hereditary cancer syndromes, who are willing to participate in ...

Early Detection of Breast Cancer Using Autoantibody Markers

PI: Tainsky, Michael A.

To identify large numbers of antigens that can be used to recognize the presence of cancer by detecting antibodies to tumor proteins in the serum of the test ...

Establishment of a serum standard for use in high-throughput proteomic

PI: Semmes, John

Expression based markers for breast cancer detection

PI: Marks, Jeffrey

High-Throughput Evaluation of Breast Cancer Markers

PI: Zangar, Richard (Rick) C.

The objective of this study is to use a combination of AMT proteomics and ELISA microarray testing to discover and validate novel biomarkers for breast cancer.

Identification of New Markers in Normal and Abnormal Pap Smears

PI: Unger, Elizabeth R.

Intergrated Systems Biology Approach for Ovarian Cancer Biomarker Discovery

PI: Diamandis, Eleftherios P.

The overall objective is to validate serum protein markers for early diagnosis of ovarian cancer with the ultimate goal being to develop a multiparametric ...

National Ovarian Cancer Early Detection Program Blood and Genetics

PI: Fishman, David

Novel approaches to study immune responses to post translational modifications for cancer detection

PI: LaBaer, Joshua

We propose to develop a BDL to discover immune-based biomarkers for the detection of breast cancers, based on fundamental tumor-specific changes in protein ...

Ovarian Cancer Screening Pilot Trial In High Risk Women

PI: Lynch, Henry

BACKGROUND: No proven ovarian cancer (OC) screening strategy exists for women who are at increased risk for the disease. A risk of ovarian cancer algorithm ...

PLCO Ovarian Phase III Validation Study

PI: Cramer, Daniel

Our preliminary data indicate that the performance of CA 125 as a screening test for ovarian cancer can be improved upon by additional biomarkers. With ...

PTM Microarray: Request for Year 3 Set-Aside Funds

PI: Zangar, Richard (Rick) C.

We hypothesize that PTMs on proteins that are secreted by the breast will provide a more sensitive method for detecting breast cancer than analysis of the ...

Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer

PI: Mor, Gil

While all cancer patients could potentially benefit from earlier detection and prevention, the development of new screening technologies and chemoprevention ...

Pre-operative plevic mass study

PI: Cramer, Daniel

Protein profiling for detection of high risk breast cancer

PI: Semmes, John

Proteomic Data Resources for EDRN Ovary Cancer Researchers within the EDRN

PI: McIntosh, Martin

This project will generate a highly valuable data resource and make it available to all EDRN ovarian cancer researchers. The resource will include ...

Proteomic Genetic and Longitudinal Pathways to Ovarian Cancer Biomarkers

PI: Skates, Steven

Discovery and verification of early detection ovarian cancer plasma/serum biomarkers.

SELDI and LC-MS/MS discovery and profiling study of hepatocarcinomas

PI: Semmes, John

SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

PI: Cramer, Daniel

Create a new set of phase II specimens (160 cases with pre-operative bloods representing major histologic types and including 80 early-staged and 80 ...

Standard Specimen Reference Set: Breast

PI: Marks, Jeffrey

The primary objective of this study is to assemble a well-characterized set of blood specimens to test biomarkers that, in conjunction with mammography, can ...

Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates

PI: Li, Christopher

The Early Detection Research Network: Biomarker Reference Laboratories

PI: Chia, David

Triple Negative Breast Cancer Team Project

PI: Anderson, Karen

Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more ...

Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)

PI: Skates, Steven

Early detection of Ovarian Cancer (OC) is one of the key clinical problems in this disease. We propose a team EDRN project to address the issue of early ...

Year 2 Collaborative Project - UCSF and Battelle PNWD

PI: Zangar, Richard (Rick) C.

To evaluate the effects of receptor status on circulating biomarker levels.

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