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Wu 6-marker phage peptide panel for Lung Cancer

Basics

Aliases:
This biomarker is also known as:

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Description…

The six-phage peptide detector stands out as a promising diagnostic biomarker for NSCLC. The peptide panel could be used to diagnose non-small cell lung cancer and to differentiate between non-small cell lung cancer and chronic obstructive pulmonary diseases. One of the six phage peptides shows 100% homology to olfactomedin 1

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Two
QA State: Curated

Overview

The sixâ€â€Å"phage peptide detector could be used to diagnose NSCLC at early stage and discriminate NSCLC and chronic obstructive pulmonary diseases. Chemotherapy significantly reduced the seroreactivity of the sixâ€â€Å"phage peptide clones. The sixâ€â€Å"phage peptide detector can be used as a novel method for noninvasive diagnosis and screening of NSCLC in high-risk populations. However, it is unlikely to be used as biomarkers for indicating the relapse of NSCLC after chemotherapy.

Performance Comment

The six-phage peptide detector was able to discriminate between NSCLC patients and healthy controls with a sensitivity and specificity of >92%, and had similar validity for indicating NSCLC at early stage. The seroreactivity of the six phage peptides was significantly higher in the NSCLC patients than in those with chemotherapy and the COPD patients, respectively.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

No associated resources found.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement