Early Detection Research Network


This biomarker is also known as:
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase),
  • Uch-L1,
  • Ubiquitin thioesterase L1,
  • UCH-L1,
  • PGP95,
  • PARK5,
  • UCHL1,
  • PGP9.5,
  • ubiquitin carboxyl-terminal hydrolase isozyme L1,
  • PGP 9.5,
  • Neuron cytoplasmic protein 9.5,
  • ubiquitin C-terminal hydrolase,


PGP9.5, also called Ubiquitin-protein hydrolase (UCHL1), is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. PGP9.5 has been proposed as a marker with a potential role in carcinogenesis.


There are no datasets associated with this biomarker.

QA State: Accepted
Type: Protein

The following organs have data associated with this biomarker…


Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.
Version 5.0.2